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Entry version 132 (25 May 2022)
Sequence version 1 (01 Mar 2001)
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Protein

Neurexin-1

Gene

NRXN1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi178CalciumBy similarity1
Metal bindingi195Calcium; via carbonyl oxygenBy similarity1
Metal bindingi263Calcium; via carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurexin-1
Alternative name(s):
Neurexin I-alpha
Neurexin-1-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRXN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini‹1 – 1287ExtracellularSequence analysisAdd BLAST›1287
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1288 – 1308HelicalSequence analysisAdd BLAST21
Topological domaini1309 – 1363CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000220496‹1 – 1363Neurexin-1Add BLAST›1363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi71 ↔ 83By similarity
Disulfide bondi77 ↔ 92By similarity
Disulfide bondi94 ↔ 104By similarity
Disulfide bondi293 ↔ 329By similarity
Disulfide bondi499 ↔ 528By similarity
Disulfide bondi536 ↔ 547By similarity
Disulfide bondi541 ↔ 556By similarity
Disulfide bondi558 ↔ 568By similarity
Glycosylationi646N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi908 ↔ 936By similarity
Disulfide bondi943 ↔ 954By similarity
Disulfide bondi948 ↔ 963By similarity
Disulfide bondi965 ↔ 975By similarity
Glycosylationi1079N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N- and O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9DDD0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The cytoplasmic C-terminal region binds to CASK. The laminin G-like domain 1 binds to NXPH1. Specific isoforms bind to alpha-dystroglycan and to alpha-latrotoxin (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000014816

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q9DDD0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9DDD0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini67 – 105EGF-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini132 – 329Laminin G-like 1PROSITE-ProRule annotationAdd BLAST198
Domaini336 – 528Laminin G-like 2PROSITE-ProRule annotationAdd BLAST193
Domaini532 – 569EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini574 – 747Laminin G-like 3PROSITE-ProRule annotationAdd BLAST174
Domaini761 – 936Laminin G-like 4PROSITE-ProRule annotationAdd BLAST176
Domaini939 – 976EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini982 – 1180Laminin G-like 5PROSITE-ProRule annotationAdd BLAST199

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1244 – 1280DisorderedSequence analysisAdd BLAST37
Regioni1330 – 1363DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1330 – 1346Polar residuesSequence analysisAdd BLAST17
Compositional biasi1347 – 1363Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the neurexin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3514, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9DDD0

Database of Orthologous Groups

More...
OrthoDBi
35129at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9DDD0

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00110, LamG, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR001791, Laminin_G
IPR003585, Neurexin-like
IPR027789, Syndecan/Neurexin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008, EGF, 1 hit
PF02210, Laminin_G_2, 5 hits
PF01034, Syndecan, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00294, 4.1m, 1 hit
SM00181, EGF, 3 hits
SM00282, LamG, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS50026, EGF_3, 3 hits
PS50025, LAM_G_DOMAIN, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry describes 10 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Note: A number of isoforms, beta-type and alpha-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus. Additional isoforms seem to exist. There are probably more than 60 isoforms. There is a combination of five alternatively spliced domains at sites 1 to 5, each consisting of modular sequences that seem to be used independently. Experimental confirmation may be lacking for some isoforms.
Isoform 1a (identifier: Q9DDD0-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
SKRRDMTVFS GLFLGGLPPE LRSATLKLTL SSVKDREPFK GWITDVRVNY
60 70 80 90 100
TQTSPVESQE VRLDDEQSRL CAREDVCLNG GVCSVLNDQA VCDCSQTGFR
110 120 130 140 150
GKDCSEEDNY VEGLAHLMMG DQGKSKGKEE YIATFKGSEY FCYDLSQNPI
160 170 180 190 200
QSSSDEITLS FKTLQRNGLM LHTGKSADYV NLALKNGAVS LVINLGSGAF
210 220 230 240 250
EALVEPVNGK FNDNAWHDVK VTRNLRQHSG IGHAMVNKLH CSVTISVDGI
260 270 280 290 300
LTTTGYTQED YTMLGSDDFF YVGGSPSTAD LPGSPVSNNF MGCLKEVVYK
310 320 330 340 350
NNDVRLELSR LAKQGDPKMK IHGVVAFKCE NVATLDPITF ETPESFISLP
360 370 380 390 400
KWNAKKTGSI SFDFRTTEPN GLILFSHGKP RHQKDAKHPQ MVKVDFFAIE
410 420 430 440 450
MLDGHLYLLL DMGSGTIKIK ALQKKVNDGE WYHVDFQRDG RSGTISVNTL
460 470 480 490 500
RTPYTAPGES EILDLDDDLY LGGLPENKAG LVFPTEVWTA LLNYGYVGCI
510 520 530 540 550
RDLFIDGQSK DIRQMAEIQS TAGVKPSCSR ETAKPCLSNP CKNNGVCRDG
560 570 580 590 600
WNRYVCDCSG TGYLGRSCER EATILSYDGS MFMKIQLPVV MHTEAEDVSL
610 620 630 640 650
RFRSQRAYGI LMATTSRESA DTLRLELDAG RVKLTVNLDC IRINCNSSKG
660 670 680 690 700
PETLFAGYNL NDNEWHTVRV VRRGKSLKLM VDDQQAMTGQ MAGDHTRLEF
710 720 730 740 750
HNIETGIITE RRYLSSVPSN FIGHLQSLTF NGMAYIDLCK NGDIDYCELN
760 770 780 790 800
ARFGFRNIIA DPVTFKTKAS YVALATLQAY TSMHLFFQFK TTSLDGLILY
810 820 830 840 850
NSGDGNDFIV VELVKGYLHY VFDLGNGANL IKGSSNKPLN DNQWHNVMIS
860 870 880 890 900
RDTNNLHTVK IDTKITTQST AGARNLDLKS DLYIGGVAKE MYKSLPKLVH
910 920 930 940 950
AKEGFQGCLA SVDLNGRLPD LISDALFCNG QIERGCEGPS TTCQEDSCAN
960 970 980 990 1000
QGVCLQQWDG FSCDCSMTSF SGPLCNDPGT TYIFSKGGGQ ITYTWPPNDR
1010 1020 1030 1040 1050
PSTRADRLAI GFSTVQKEAV LVRVDSSTGL GDYLELHIHQ GKIGVKFNVG
1060 1070 1080 1090 1100
TDDIAIEEIN AIINDGKYHV VRFTRSGGNA TLQVDNWPVI ERYPAGNNDN
1110 1120 1130 1140 1150
ERLAIARQRI PYRLGRVVDE WLLDKGRQLT IFNSQATIKI GGKERGHPFQ
1160 1170 1180 1190 1200
GQLSGLYYNG LKVLNMAAEN DANIVIEGNV RLVGEVPSSM TTESTATAMQ
1210 1220 1230 1240 1250
SEMSTSVMET TTTLATSTAR RGKAPTKEPI GQTTDDILVA SAECPSDDED
1260 1270 1280 1290 1300
IDPCEPSSGG LANPTRAGGG REYPGSSEVI RESSSTTGMV VGIVAAAALC
1310 1320 1330 1340 1350
ILILLYAMYK YRNRDEGSYH VDESRNYISN SAQSNGAVIK EKQPNSAKSS
1360
NKNKKNKDKE YYV
Length:1,363
Mass (Da):150,076
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF16374F884D20713
GO
Isoform 2a (identifier: Q9DDD0-2) [UniParc]FASTAAdd to basket
Also known as: Alpha-1,2

The sequence of this isoform differs from the canonical sequence as follows:
     123-126: Missing.

Show »
Length:1,359
Mass (Da):149,676
Checksum:iB7481107DD55D635
GO
Isoform 3a (identifier: Q9DDD0-3) [UniParc]FASTAAdd to basket
Also known as: Alpha-1,3

The sequence of this isoform differs from the canonical sequence as follows:
     106-111: Missing.

Show »
Length:1,357
Mass (Da):149,327
Checksum:i30A46D8672F8EB3A
GO
Isoform 4a (identifier: Q9DDD0-4) [UniParc]FASTAAdd to basket
Also known as: Alpha-1,4

The sequence of this isoform differs from the canonical sequence as follows:
     106-111: Missing.
     123-126: Missing.

Show »
Length:1,353
Mass (Da):148,926
Checksum:i9162FD2E4E4CE176
GO
Isoform 5a (identifier: Q9DDD0-5) [UniParc]FASTAAdd to basket
Also known as: Alpha-1,5

The sequence of this isoform differs from the canonical sequence as follows:
     106-126: Missing.

Show »
Length:1,342
Mass (Da):147,743
Checksum:i069DAAD9C7EB487B
GO
Isoform 6a (identifier: Q9DDD0-6) [UniParc]FASTAAdd to basket
Also known as: Alpha-2,5

The sequence of this isoform differs from the canonical sequence as follows:
     236-242: Missing.

Show »
Length:1,356
Mass (Da):149,294
Checksum:i1C3CCAC27C58CB44
GO
Isoform 7a (identifier: Q9DDD0-7) [UniParc]FASTAAdd to basket
Also known as: Alpha-2,8

The sequence of this isoform differs from the canonical sequence as follows:
     228-242: Missing.

Show »
Length:1,348
Mass (Da):148,503
Checksum:iDA1CFC45F1DE7EB4
GO
Isoform 8a (identifier: Q9DDD0-8) [UniParc]FASTAAdd to basket
Also known as: Alpha-4,10

The sequence of this isoform differs from the canonical sequence as follows:
     1096-1125: Missing.

Show »
Length:1,333
Mass (Da):146,513
Checksum:i6146DEB7409C56FE
GO
Isoform 9a (identifier: Q9DDD0-9) [UniParc]FASTAAdd to basket
Also known as: Alpha-5,13

The sequence of this isoform differs from the canonical sequence as follows:
     1259-1261: Missing.

Show »
Length:1,360
Mass (Da):149,849
Checksum:iED588F450DC56C26
GO
Isoform 1b (identifier: D0PRN2-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry D0PRN2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:466
Mass (Da):49,956
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003498106 – 126Missing in isoform 5a. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_003499106 – 111Missing in isoform 3a and isoform 4a. 1 Publication6
Alternative sequenceiVSP_003500123 – 126Missing in isoform 2a and isoform 4a. 1 Publication4
Alternative sequenceiVSP_003501228 – 242Missing in isoform 7a. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_003502236 – 242Missing in isoform 6a. 1 Publication7
Alternative sequenceiVSP_0035031096 – 1125Missing in isoform 8a. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_0035041259 – 1261Missing in isoform 9a. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ300473 mRNA Translation: CAC17606.1

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ300473 mRNA Translation: CAC17606.1

3D structure databases

AlphaFoldDBiQ9DDD0
SMRiQ9DDD0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014816

Proteomic databases

PaxDbiQ9DDD0

Phylogenomic databases

eggNOGiKOG3514, Eukaryota
InParanoidiQ9DDD0
OrthoDBi35129at2759
PhylomeDBiQ9DDD0

Family and domain databases

CDDicd00110, LamG, 5 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR001791, Laminin_G
IPR003585, Neurexin-like
IPR027789, Syndecan/Neurexin_dom
PfamiView protein in Pfam
PF00008, EGF, 1 hit
PF02210, Laminin_G_2, 5 hits
PF01034, Syndecan, 1 hit
SMARTiView protein in SMART
SM00294, 4.1m, 1 hit
SM00181, EGF, 3 hits
SM00282, LamG, 5 hits
SUPFAMiSSF49899, SSF49899, 5 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS50026, EGF_3, 3 hits
PS50025, LAM_G_DOMAIN, 5 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRX1A_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9DDD0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: May 25, 2022
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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