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Protein

Protein kinase C and casein kinase substrate in neurons protein 2

Gene

pacsin2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane and thereby may play a role in caveola-mediated endocytosis. May regulate adam13 activity by influencing either its subcellular localization or its catalytic activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processEndocytosis
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C and casein kinase substrate in neurons protein 2
Short name:
x-PACSIN2
Gene namesi
Name:pacsin2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-489582 pacsin2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001617991 – 477Protein kinase C and casein kinase substrate in neurons protein 2Add BLAST477

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in the ectoderm, the neuroectoderm, and dorsal mesoderm layers.1 Publication

Developmental stagei

Expressed in two-cell stage, early blastula, early gastrula, early neurula and early and late tail bud stages.

Interactioni

Subunit structurei

Interacts with adam13 through the SH3 domains.

Structurei

3D structure databases

ProteinModelPortaliQ9DDA9
SMRiQ9DDA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 282F-BARPROSITE-ProRule annotationAdd BLAST272
Domaini417 – 477SH3PROSITE-ProRule annotationAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili25 – 274By similarityAdd BLAST250

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi356 – 358NPF13
Motifi396 – 398NPF23
Motifi408 – 410NPF33

Domaini

The F-BAR domain forms a coiled coil and mediates membrane-binding and membrane tubulation. In the autoinhibited conformation, interaction with the SH3 domain inhibits membrane tubulation mediated by the F-BAR domain (By similarity).By similarity

Sequence similaritiesi

Belongs to the PACSIN family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

HOVERGENiHBG053486
KOiK20123

Family and domain databases

CDDicd07679 F-BAR_PACSIN2, 1 hit
cd11998 SH3_PACSIN1-2, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR035743 PACSIN1/PACSIN2_SH3
IPR028521 PACSIN2
IPR037453 PACSIN2_F-BAR
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR23065:SF14 PTHR23065:SF14, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DDA9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCND LMNCIHERAR
60 70 80 90 100
IEKVYAQQLT EWAKRWKQLV ERGPQYGTVE KAWHNLMTEA EKVSELHLEV
110 120 130 140 150
KNALMNEDFE KIKNWQKEAF HKQMMGGFKE TKEADDGFRK AQKPWAKKLK
160 170 180 190 200
EVEAAKKSYH AACKEEKLAT SRETNSKADP AMNPEQLKKL QDKVEKSKQD
210 220 230 240 250
SQKTKEKYEK SLKDLDGTTP QYMENMEQVF EQCQQFEDKR LSFFREVLLE
260 270 280 290 300
VEKHLDLSNV ESYASIYREL EYAIKSADAM EDLKWFRNNH GPGMSMNWPQ
310 320 330 340 350
FEDWSADLNR TLSRREKKKP TDGVTLTGIS QSGEQSSIQN QHSSHLSVQS
360 370 380 390 400
AQSTNNPFED EEETVSINET ENKKIENVGS YEKTHPAEWS DDESNNPFNP
410 420 430 440 450
SDTNGDNNPF DEDALTTLEV RVRALYDYDG QELDELSFKA GEELTKIEDE
460 470
DEQGWCKGRL EGGQVGLYPA NYVESVQ
Length:477
Mass (Da):55,148
Last modified:March 1, 2001 - v1
Checksum:iFA6D187769EF93B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277159 mRNA Translation: CAC17814.1
BC071076 mRNA Translation: AAH71076.1
RefSeqiNP_001081950.1, NM_001088481.1
UniGeneiXl.52492

Genome annotation databases

GeneIDi398138
KEGGixla:398138

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277159 mRNA Translation: CAC17814.1
BC071076 mRNA Translation: AAH71076.1
RefSeqiNP_001081950.1, NM_001088481.1
UniGeneiXl.52492

3D structure databases

ProteinModelPortaliQ9DDA9
SMRiQ9DDA9
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398138
KEGGixla:398138

Organism-specific databases

CTDi398138
XenbaseiXB-GENE-489582 pacsin2

Phylogenomic databases

HOVERGENiHBG053486
KOiK20123

Family and domain databases

CDDicd07679 F-BAR_PACSIN2, 1 hit
cd11998 SH3_PACSIN1-2, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR035743 PACSIN1/PACSIN2_SH3
IPR028521 PACSIN2
IPR037453 PACSIN2_F-BAR
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR23065:SF14 PTHR23065:SF14, 1 hit
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPACN2_XENLA
AccessioniPrimary (citable) accession number: Q9DDA9
Secondary accession number(s): Q6GR55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: March 1, 2001
Last modified: February 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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