UniProtKB - Q9DD16 (NUD22_MOUSE)
Protein
Uridine diphosphate glucose pyrophosphatase NUDT22
Gene
Nudt22
Organism
Mus musculus (Mouse)
Status
Functioni
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose.By similarity
Catalytic activityi
- UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate.By similarity EC:3.6.1.45
Cofactori
Mg2+By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 56 | Substrate; via amide nitrogen and carbonyl oxygenBy similarity | 1 | |
Binding sitei | 86 | SubstrateBy similarity | 1 | |
Binding sitei | 138 | SubstrateBy similarity | 1 | |
Binding sitei | 143 | Substrate; via amide nitrogenBy similarity | 1 | |
Binding sitei | 150 | SubstrateBy similarity | 1 | |
Binding sitei | 155 | SubstrateBy similarity | 1 | |
Binding sitei | 157 | SubstrateBy similarity | 1 | |
Metal bindingi | 188 | MagnesiumBy similarity | 1 | |
Metal bindingi | 192 | MagnesiumBy similarity | 1 | |
Binding sitei | 273 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- GDP-mannose hydrolase activity Source: GO_Central
- metal ion binding Source: UniProtKB
- UDP-sugar diphosphatase activity Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Ligand | Magnesium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Uridine diphosphate glucose pyrophosphatase NUDT22 (EC:3.6.1.45)Short name: UDPG pyrophosphatase Short name: UGPPase Alternative name(s): Nucleoside diphosphate-linked moiety X motif 22 Short name: Nudix motif 22 |
Gene namesi | Name:Nudt22 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915573, Nudt22 |
Subcellular locationi
Nucleus
- nucleoplasm Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000263732 | 1 – 308 | Uridine diphosphate glucose pyrophosphatase NUDT22Add BLAST | 308 |
Proteomic databases
EPDi | Q9DD16 |
MaxQBi | Q9DD16 |
PaxDbi | Q9DD16 |
PRIDEi | Q9DD16 |
PTM databases
iPTMneti | Q9DD16 |
PhosphoSitePlusi | Q9DD16 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000037349, Expressed in pancreas and 230 other tissues |
Genevisiblei | Q9DD16, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000041419 |
Miscellaneous databases
RNActi | Q9DD16, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 117 – 284 | Nudix hydrolasePROSITE-ProRule annotationAdd BLAST | 168 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 174 – 195 | Nudix boxBy similarityAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the Nudix hydrolase family.Curated
Phylogenomic databases
eggNOGi | ENOG502QRSW, Eukaryota |
GeneTreei | ENSGT00390000017869 |
HOGENOMi | CLU_061819_1_0_1 |
InParanoidi | Q9DD16 |
OMAi | CDEVNVP |
OrthoDBi | 1587403at2759 |
PhylomeDBi | Q9DD16 |
TreeFami | TF106357 |
Family and domain databases
InterProi | View protein in InterPro IPR000086, NUDIX_hydrolase_dom |
PROSITEi | View protein in PROSITE PS51462, NUDIX, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9DD16-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPEVSLLLL CPLGGLSQEQ VAVELSPAHD RRPLPGGDKA ITAIWETRQQ
60 70 80 90 100
AQPWIFDAPK FRLHSATLVS SSPEPQLLLH LGLTSYRDFL GTNWSSSASW
110 120 130 140 150
LRQQGAADWG DKQAYLADPL GVGAALVTAD DFLVFLRRSQ QVAEAPGLVD
160 170 180 190 200
VPGGHPEPQA LCSGGIPRHK DLPGLLVVRE LFSSVLQEIC DEVNLPLHTL
210 220 230 240 250
SQPLLLGIAC NETSAGRASA EFYVQCSLTS EEVRSYYLSG GPEAHESTGI
260 270 280 290 300
IFVETQRVQR LQETEMWAQL CPSAKGAILL YNRHPPLQSG VGKSHLSHPS
APALSLQL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 175 | L → E in AAH19768 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002252 mRNA Translation: BAB21966.1 BC019768 mRNA Translation: AAH19768.1 |
CCDSi | CCDS29517.1 |
RefSeqi | NP_080951.1, NM_026675.2 |
Genome annotation databases
Ensembli | ENSMUST00000041686; ENSMUSP00000041419; ENSMUSG00000037349 ENSMUST00000180765; ENSMUSP00000137738; ENSMUSG00000037349 |
GeneIDi | 68323 |
KEGGi | mmu:68323 |
UCSCi | uc008gjz.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002252 mRNA Translation: BAB21966.1 BC019768 mRNA Translation: AAH19768.1 |
CCDSi | CCDS29517.1 |
RefSeqi | NP_080951.1, NM_026675.2 |
3D structure databases
SMRi | Q9DD16 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000041419 |
PTM databases
iPTMneti | Q9DD16 |
PhosphoSitePlusi | Q9DD16 |
Proteomic databases
EPDi | Q9DD16 |
MaxQBi | Q9DD16 |
PaxDbi | Q9DD16 |
PRIDEi | Q9DD16 |
Protocols and materials databases
Antibodypediai | 51889, 91 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000041686; ENSMUSP00000041419; ENSMUSG00000037349 ENSMUST00000180765; ENSMUSP00000137738; ENSMUSG00000037349 |
GeneIDi | 68323 |
KEGGi | mmu:68323 |
UCSCi | uc008gjz.1, mouse |
Organism-specific databases
CTDi | 84304 |
MGIi | MGI:1915573, Nudt22 |
Phylogenomic databases
eggNOGi | ENOG502QRSW, Eukaryota |
GeneTreei | ENSGT00390000017869 |
HOGENOMi | CLU_061819_1_0_1 |
InParanoidi | Q9DD16 |
OMAi | CDEVNVP |
OrthoDBi | 1587403at2759 |
PhylomeDBi | Q9DD16 |
TreeFami | TF106357 |
Miscellaneous databases
BioGRID-ORCSi | 68323, 0 hits in 17 CRISPR screens |
PROi | PR:Q9DD16 |
RNActi | Q9DD16, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037349, Expressed in pancreas and 230 other tissues |
Genevisiblei | Q9DD16, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000086, NUDIX_hydrolase_dom |
PROSITEi | View protein in PROSITE PS51462, NUDIX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NUD22_MOUSE | |
Accessioni | Q9DD16Primary (citable) accession number: Q9DD16 Secondary accession number(s): Q8VCI4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families