UniProtKB - Q9DCZ1 (GMPR1_MOUSE)
Protein
GMP reductase 1
Gene
Gmpr
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.UniRule annotation
Catalytic activityi
- EC:1.7.1.7UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 78 | NADPUniRule annotation | 1 | |
Metal bindingi | 181 | Potassium; via carbonyl oxygenUniRule annotation | 1 | |
Metal bindingi | 183 | Potassium; via carbonyl oxygenUniRule annotation | 1 | |
Active sitei | 186 | Thioimidate intermediateUniRule annotation | 1 | |
Metal bindingi | 186 | Potassium; via carbonyl oxygenUniRule annotation | 1 | |
Active sitei | 188 | Proton donor/acceptorUniRule annotation | 1 | |
Metal bindingi | 189 | PotassiumUniRule annotation | 1 | |
Binding sitei | 269 | NADP; via carbonyl oxygenUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 26 – 27 | NADP; shared with neighboring subunitUniRule annotation | 2 | |
Nucleotide bindingi | 129 – 131 | NADPUniRule annotation | 3 | |
Nucleotide bindingi | 180 – 181 | NADPUniRule annotation | 2 | |
Nucleotide bindingi | 285 – 286 | NADPUniRule annotation | 2 | |
Nucleotide bindingi | 314 – 317 | NADP; shared with neighboring subunitUniRule annotation | 4 |
GO - Molecular functioni
- GMP reductase activity Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- purine nucleobase metabolic process Source: UniProtKB-KW
- purine nucleotide metabolic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Purine metabolism |
Ligand | Metal-binding, NADP, Potassium |
Enzyme and pathway databases
Reactomei | R-MMU-74217, Purine salvage |
Names & Taxonomyi
Protein namesi | Recommended name: GMP reductase 1UniRule annotation (EC:1.7.1.7UniRule annotation)Short name: GMPR 1UniRule annotation Alternative name(s): Guanosine 5'-monophosphate oxidoreductase 1UniRule annotation Short name: Guanosine monophosphate reductase 1UniRule annotation |
Gene namesi | Name:Gmpr Synonyms:Gmpr1UniRule annotation |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1913605, Gmpr |
Subcellular locationi
Other locations
- GMP reductase complex Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093724 | 1 – 345 | GMP reductase 1Add BLAST | 345 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 28 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3648 |
jPOSTi | Q9DCZ1 |
MaxQBi | Q9DCZ1 |
PaxDbi | Q9DCZ1 |
PeptideAtlasi | Q9DCZ1 |
PRIDEi | Q9DCZ1 |
PTM databases
iPTMneti | Q9DCZ1 |
PhosphoSitePlusi | Q9DCZ1 |
SwissPalmi | Q9DCZ1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000000253, Expressed in fetal liver hematopoietic progenitor cell and 299 other tissues |
Genevisiblei | Q9DCZ1, MM |
Interactioni
Subunit structurei
Homotetramer.
UniRule annotationProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000000260 |
Miscellaneous databases
RNActi | Q9DCZ1, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 219 – 221 | GMP bindingUniRule annotation | 3 | |
Regioni | 242 – 243 | GMP bindingUniRule annotation | 2 | |
Regioni | 268 – 270 | GMP bindingUniRule annotation | 3 | |
Regioni | 286 – 290 | GMP bindingUniRule annotation | 5 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2550, Eukaryota |
GeneTreei | ENSGT00940000156595 |
HOGENOMi | CLU_022552_5_3_1 |
InParanoidi | Q9DCZ1 |
OMAi | GSHCTTR |
OrthoDBi | 618077at2759 |
PhylomeDBi | Q9DCZ1 |
TreeFami | TF300378 |
Family and domain databases
CDDi | cd00381, IMPDH, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_00596, GMP_reduct_type1, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR005993, GMPR IPR015875, IMP_DH/GMP_Rdtase_CS IPR001093, IMP_DH_GMPRt |
Pfami | View protein in Pfam PF00478, IMPDH, 1 hit |
PIRSFi | PIRSF000235, GMP_reductase, 1 hit |
TIGRFAMsi | TIGR01305, GMP_reduct_1, 1 hit |
PROSITEi | View protein in PROSITE PS00487, IMP_DH_GMP_RED, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9DCZ1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRIDADLKL DFKDVLLRPK RSSLKSRSEV DLERTFTFRN SKQTYSGIPI
60 70 80 90 100
IVANMDTVGT FEMAVVMSQH AMFTAVHKHY SLDDWKCFAE THPECLQHVA
110 120 130 140 150
VSSGSGQNDL ERMSRILEAV PQVKFICLDV ANGYSEHFVE FVKLVRSKFP
160 170 180 190 200
EHTIMAGNVV TGEMVEELIL SGADIIKVGV GPGSVCTTRT KTGVGYPQLS
210 220 230 240 250
AVIECADSAH GLKGHIISDG GCTCPGDVAK AFGAGADFVM LGGMFSGHTE
260 270 280 290 300
CAGEVIERNG QKLKLFYGMS SDTAMKKHAG GVAEYRASEG KTVEVPYKGD
310 320 330 340
VENTILDILG GLRSTCTYVG AAKLKELSRR ATFIRVTQQH NTVFG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF6VY18 | F6VY18_MOUSE | GMP reductase | Gmpr | 290 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002326 mRNA Translation: BAB22014.1 AK084508 mRNA Translation: BAC39203.1 BC010827 mRNA Translation: AAH10827.1 |
CCDSi | CCDS26482.1 |
RefSeqi | NP_079784.1, NM_025508.5 |
Genome annotation databases
Ensembli | ENSMUST00000000260; ENSMUSP00000000260; ENSMUSG00000000253 |
GeneIDi | 66355 |
KEGGi | mmu:66355 |
UCSCi | uc007qha.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002326 mRNA Translation: BAB22014.1 AK084508 mRNA Translation: BAC39203.1 BC010827 mRNA Translation: AAH10827.1 |
CCDSi | CCDS26482.1 |
RefSeqi | NP_079784.1, NM_025508.5 |
3D structure databases
SMRi | Q9DCZ1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000000260 |
PTM databases
iPTMneti | Q9DCZ1 |
PhosphoSitePlusi | Q9DCZ1 |
SwissPalmi | Q9DCZ1 |
Proteomic databases
CPTACi | non-CPTAC-3648 |
jPOSTi | Q9DCZ1 |
MaxQBi | Q9DCZ1 |
PaxDbi | Q9DCZ1 |
PeptideAtlasi | Q9DCZ1 |
PRIDEi | Q9DCZ1 |
Protocols and materials databases
Antibodypediai | 10292, 153 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000000260; ENSMUSP00000000260; ENSMUSG00000000253 |
GeneIDi | 66355 |
KEGGi | mmu:66355 |
UCSCi | uc007qha.1, mouse |
Organism-specific databases
CTDi | 2766 |
MGIi | MGI:1913605, Gmpr |
Phylogenomic databases
eggNOGi | KOG2550, Eukaryota |
GeneTreei | ENSGT00940000156595 |
HOGENOMi | CLU_022552_5_3_1 |
InParanoidi | Q9DCZ1 |
OMAi | GSHCTTR |
OrthoDBi | 618077at2759 |
PhylomeDBi | Q9DCZ1 |
TreeFami | TF300378 |
Enzyme and pathway databases
Reactomei | R-MMU-74217, Purine salvage |
Miscellaneous databases
BioGRID-ORCSi | 66355, 0 hits in 17 CRISPR screens |
PROi | PR:Q9DCZ1 |
RNActi | Q9DCZ1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000000253, Expressed in fetal liver hematopoietic progenitor cell and 299 other tissues |
Genevisiblei | Q9DCZ1, MM |
Family and domain databases
CDDi | cd00381, IMPDH, 1 hit |
Gene3Di | 3.20.20.70, 1 hit |
HAMAPi | MF_00596, GMP_reduct_type1, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR005993, GMPR IPR015875, IMP_DH/GMP_Rdtase_CS IPR001093, IMP_DH_GMPRt |
Pfami | View protein in Pfam PF00478, IMPDH, 1 hit |
PIRSFi | PIRSF000235, GMP_reductase, 1 hit |
TIGRFAMsi | TIGR01305, GMP_reduct_1, 1 hit |
PROSITEi | View protein in PROSITE PS00487, IMP_DH_GMP_RED, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GMPR1_MOUSE | |
Accessioni | Q9DCZ1Primary (citable) accession number: Q9DCZ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2002 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families