UniProtKB - Q9DCY1 (Q9DCY1_MOUSE)
Protein
Peptidyl-prolyl cis-trans isomerase
Gene
Ppib
Organism
Mus musculus (Mouse)
Status
Functioni
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.UniRule annotation
Catalytic activityi
- EC:5.2.1.8UniRule annotation
GO - Molecular functioni
- cyclosporin A binding Source: Ensembl
- peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-UniRule
- RNA polymerase binding Source: Ensembl
GO - Biological processi
- bone development Source: Ensembl
- chaperone-mediated protein folding Source: Ensembl
- neutrophil chemotaxis Source: Ensembl
- positive regulation by host of viral genome replication Source: Ensembl
- positive regulation of multicellular organism growth Source: Ensembl
- protein stabilization Source: Ensembl
Keywordsi
Molecular function | Isomerase, RotamaseUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)Short name: PPIaseUniRule annotation |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:97750, Ppib |
Subcellular locationi
Endoplasmic reticulum
- smooth endoplasmic reticulum Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
Other locations
- perinuclear region of cytoplasm Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032383, Expressed in pancreas and 309 other tissues |
ExpressionAtlasi | Q9DCY1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 204 | PPIase cyclophilin-typeInterPro annotationAdd BLAST | 158 |
Sequence similaritiesi
Belongs to the cyclophilin-type PPIase family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_012062_4_2_1 |
OMAi | DVTIHDC |
OrthoDBi | 1403619at2759 |
Family and domain databases
Gene3Di | 2.40.100.10, 1 hit |
InterProi | View protein in InterPro IPR029000, Cyclophilin-like_dom_sf IPR020892, Cyclophilin-type_PPIase_CS IPR002130, Cyclophilin-type_PPIase_dom |
Pfami | View protein in Pfam PF00160, Pro_isomerase, 1 hit |
PRINTSi | PR00153, CSAPPISMRASE |
SUPFAMi | SSF50891, SSF50891, 1 hit |
PROSITEi | View protein in PROSITE PS00170, CSA_PPIASE_1, 1 hit PS50072, CSA_PPIASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9DCY1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRLSERNMK VLFAAALIVG SVVFLLLPGP SVANDKKKGP KVTVKVYFDL
60 70 80 90 100
QIGDESVGRV VFGLFGKTVP KTVDNFVALA TGEKGFGYKN SKFHRVIKDF
110 120 130 140 150
MIQGGDFTRG DGTGGKSIYG ERFPDENFKL KHYGPGWVSM ANAGKDTNGS
160 170 180 190 200
QFFITTVKTS WLDGKHVVFG KVLEGMDVVR KVESTKTDSR DKPLKDVIIV
210
DSGKIEVEKP FAIAKE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC013061 mRNA Translation: AAH13061.1 AK002357 mRNA Translation: BAB22036.1 AK154073 mRNA Translation: BAE32357.1 |
PIRi | A56861 |
RefSeqi | NP_035279.2, NM_011149.2 |
Genome annotation databases
GeneIDi | 19035 |
KEGGi | mmu:19035 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC013061 mRNA Translation: AAH13061.1 AK002357 mRNA Translation: BAB22036.1 AK154073 mRNA Translation: BAE32357.1 |
PIRi | A56861 |
RefSeqi | NP_035279.2, NM_011149.2 |
3D structure databases
SMRi | Q9DCY1 |
ModBasei | Search... |
Proteomic databases
EPDi | Q9DCY1 |
MaxQBi | Q9DCY1 |
PRIDEi | Q9DCY1 |
TopDownProteomicsi | Q9DCY1 |
Protocols and materials databases
Antibodypediai | 2584, 473 antibodies |
Genome annotation databases
GeneIDi | 19035 |
KEGGi | mmu:19035 |
Organism-specific databases
CTDi | 5479 |
MGIi | MGI:97750, Ppib |
Phylogenomic databases
HOGENOMi | CLU_012062_4_2_1 |
OMAi | DVTIHDC |
OrthoDBi | 1403619at2759 |
Miscellaneous databases
BioGRID-ORCSi | 19035, 2 hits in 18 CRISPR screens |
ChiTaRSi | Ppib, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032383, Expressed in pancreas and 309 other tissues |
ExpressionAtlasi | Q9DCY1, baseline and differential |
Family and domain databases
Gene3Di | 2.40.100.10, 1 hit |
InterProi | View protein in InterPro IPR029000, Cyclophilin-like_dom_sf IPR020892, Cyclophilin-type_PPIase_CS IPR002130, Cyclophilin-type_PPIase_dom |
Pfami | View protein in Pfam PF00160, Pro_isomerase, 1 hit |
PRINTSi | PR00153, CSAPPISMRASE |
SUPFAMi | SSF50891, SSF50891, 1 hit |
PROSITEi | View protein in PROSITE PS00170, CSA_PPIASE_1, 1 hit PS50072, CSA_PPIASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9DCY1_MOUSE | |
Accessioni | Q9DCY1Primary (citable) accession number: Q9DCY1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2001 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |