UniProtKB - Q9DCX2 (ATP5H_MOUSE)
ATP synthase subunit d, mitochondrial
Atp5pd
Functioni
GO - Molecular functioni
- protein-containing complex binding Source: MGI
- proton-transporting ATP synthase activity, rotational mechanism Source: Ensembl
GO - Biological processi
- ATP metabolic process Source: MGI
- ATP synthesis coupled proton transport Source: GO_Central
- mitochondrial ATP synthesis coupled proton transport Source: MGI
Keywordsi
Biological process | Hydrogen ion transport, Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-163210, Formation of ATP by chemiosmotic coupling R-MMU-8949613, Cristae formation |
Names & Taxonomyi
Protein namesi | Recommended name: ATP synthase subunit d, mitochondrialCuratedShort name: ATPase subunit d Alternative name(s): ATP synthase peripheral stalk subunit dCurated |
Gene namesi | Name:Atp5pdBy similarity Synonyms:Atp5h |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1918929, Atp5h |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial inner membrane Source: MGI
- mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
- mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Source: MGI
- mitochondrial proton-transporting ATP synthase, stator stalk Source: GO_Central
- mitochondrion Source: UniProtKB
Other locations
- myelin sheath Source: UniProtKB
Keywords - Cellular componenti
CF(0), Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000071674 | 2 – 161 | ATP synthase subunit d, mitochondrialAdd BLAST | 160 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 32 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 48 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 63 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 72 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 78 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 78 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 85 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 85 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 95 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 95 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 117 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 144 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 144 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 149 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 149 | N6-succinyllysine; alternateCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
CPTACi | non-CPTAC-3637 |
EPDi | Q9DCX2 |
jPOSTi | Q9DCX2 |
MaxQBi | Q9DCX2 |
PaxDbi | Q9DCX2 |
PeptideAtlasi | Q9DCX2 |
PRIDEi | Q9DCX2 |
TopDownProteomicsi | Q9DCX2 |
2D gel databases
REPRODUCTION-2DPAGEi | Q9DCX2 |
PTM databases
iPTMneti | Q9DCX2 |
PhosphoSitePlusi | Q9DCX2 |
SwissPalmi | Q9DCX2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000034566, Expressed in brain and 82 other tissues |
ExpressionAtlasi | Q9DCX2, baseline and differential |
Genevisiblei | Q9DCX2, MM |
Interactioni
Subunit structurei
F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L).
Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MD and ATP5MPL (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 214850, 67 interactors |
IntActi | Q9DCX2, 8 interactors |
MINTi | Q9DCX2 |
STRINGi | 10090.ENSMUSP00000102147 |
Miscellaneous databases
RNActi | Q9DCX2, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3366, Eukaryota |
GeneTreei | ENSGT00390000003582 |
HOGENOMi | CLU_130600_0_0_1 |
InParanoidi | Q9DCX2 |
OMAi | PYPQDKV |
OrthoDBi | 1299717at2759 |
PhylomeDBi | Q9DCX2 |
TreeFami | TF314031 |
Family and domain databases
Gene3Di | 1.20.58.880, 1 hit |
InterProi | View protein in InterPro IPR008689, ATP_synth_F0_dsu_mt IPR036228, ATP_synth_F0_dsu_sf_mt |
PANTHERi | PTHR12700, PTHR12700, 1 hit |
Pfami | View protein in Pfam PF05873, Mt_ATP-synt_D, 1 hit |
PIRSFi | PIRSF005514, ATPase_F0_D_mt, 1 hit |
SUPFAMi | SSF161065, SSF161065, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAGRKLALKT IDWVSFVEVM PQNQKAIGNA LKSWNETFHA RLASLSEKPP
60 70 80 90 100
AIDWAYYRAN VAKPGLVDDF EKKYNALKIP VPEDKYTALV DQEEKEDVKS
110 120 130 140 150
CAEFVSGSQL RIQEYEKQLE KMRNIIPFDQ MTIDDLNEIF PETKLDKKKY
160
PYWPHQPIEN L
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB1ASE2 | B1ASE2_MOUSE | ATP synthase subunit d, mitochondri... | Atp5h | 138 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 90 | V → L in AAH16547 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 159 – 161 | ENL → LMC AA sequence (Ref. 6) Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF354051 mRNA Translation: AAL83962.1 AK002376 mRNA Translation: BAB22053.1 AK088617 mRNA Translation: BAC40456.1 AL627096 Genomic DNA No translation available. BC016547 mRNA Translation: AAH16547.1 BC081431 mRNA Translation: AAH81431.1 |
CCDSi | CCDS25633.1 |
PIRi | PN0046 |
RefSeqi | NP_082138.1, NM_027862.1 XP_006534317.1, XM_006534254.1 |
Genome annotation databases
Ensembli | ENSMUST00000043931; ENSMUSP00000046256; ENSMUSG00000034566 ENSMUST00000073791; ENSMUSP00000086072; ENSMUSG00000034566 ENSMUST00000106537; ENSMUSP00000102147; ENSMUSG00000034566 ENSMUST00000180072; ENSMUSP00000137071; ENSMUSG00000034566 |
GeneIDi | 71679 |
KEGGi | mmu:71679 |
UCSCi | uc007mhm.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF354051 mRNA Translation: AAL83962.1 AK002376 mRNA Translation: BAB22053.1 AK088617 mRNA Translation: BAC40456.1 AL627096 Genomic DNA No translation available. BC016547 mRNA Translation: AAH16547.1 BC081431 mRNA Translation: AAH81431.1 |
CCDSi | CCDS25633.1 |
PIRi | PN0046 |
RefSeqi | NP_082138.1, NM_027862.1 XP_006534317.1, XM_006534254.1 |
3D structure databases
SMRi | Q9DCX2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 214850, 67 interactors |
IntActi | Q9DCX2, 8 interactors |
MINTi | Q9DCX2 |
STRINGi | 10090.ENSMUSP00000102147 |
PTM databases
iPTMneti | Q9DCX2 |
PhosphoSitePlusi | Q9DCX2 |
SwissPalmi | Q9DCX2 |
2D gel databases
REPRODUCTION-2DPAGEi | Q9DCX2 |
Proteomic databases
CPTACi | non-CPTAC-3637 |
EPDi | Q9DCX2 |
jPOSTi | Q9DCX2 |
MaxQBi | Q9DCX2 |
PaxDbi | Q9DCX2 |
PeptideAtlasi | Q9DCX2 |
PRIDEi | Q9DCX2 |
TopDownProteomicsi | Q9DCX2 |
Protocols and materials databases
Antibodypediai | 32083, 240 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 71679 |
MGIi | MGI:1918929, Atp5h |
Phylogenomic databases
eggNOGi | KOG3366, Eukaryota |
GeneTreei | ENSGT00390000003582 |
HOGENOMi | CLU_130600_0_0_1 |
InParanoidi | Q9DCX2 |
OMAi | PYPQDKV |
OrthoDBi | 1299717at2759 |
PhylomeDBi | Q9DCX2 |
TreeFami | TF314031 |
Enzyme and pathway databases
Reactomei | R-MMU-163210, Formation of ATP by chemiosmotic coupling R-MMU-8949613, Cristae formation |
Miscellaneous databases
BioGRID-ORCSi | 71679, 6 hits in 19 CRISPR screens |
ChiTaRSi | Atp5h, mouse |
PROi | PR:Q9DCX2 |
RNActi | Q9DCX2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034566, Expressed in brain and 82 other tissues |
ExpressionAtlasi | Q9DCX2, baseline and differential |
Genevisiblei | Q9DCX2, MM |
Family and domain databases
Gene3Di | 1.20.58.880, 1 hit |
InterProi | View protein in InterPro IPR008689, ATP_synth_F0_dsu_mt IPR036228, ATP_synth_F0_dsu_sf_mt |
PANTHERi | PTHR12700, PTHR12700, 1 hit |
Pfami | View protein in Pfam PF05873, Mt_ATP-synt_D, 1 hit |
PIRSFi | PIRSF005514, ATPase_F0_D_mt, 1 hit |
SUPFAMi | SSF161065, SSF161065, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATP5H_MOUSE | |
Accessioni | Q9DCX2Primary (citable) accession number: Q9DCX2 Secondary accession number(s): B1ASE1 Q91YK9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 15, 2002 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 163 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families