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Protein

MAD2L1-binding protein

Gene

Mad2l1bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
MAD2L1-binding protein
Gene namesi
Name:Mad2l1bp
Synonyms:Mad2lbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1913841 Mad2l1bp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000963111 – 276MAD2L1-binding proteinAdd BLAST276

Proteomic databases

EPDiQ9DCX1
MaxQBiQ9DCX1
PaxDbiQ9DCX1
PeptideAtlasiQ9DCX1
PRIDEiQ9DCX1

PTM databases

PhosphoSitePlusiQ9DCX1

Expressioni

Gene expression databases

BgeeiENSMUSG00000034509 Expressed in 248 organ(s), highest expression level in embryo
CleanExiMM_MAD2L1BP
GenevisibleiQ9DCX1 MM

Interactioni

Subunit structurei

Interacts with MAD2L1.By similarity

Protein-protein interaction databases

BioGridi211577, 30 interactors
IntActiQ9DCX1, 32 interactors
MINTiQ9DCX1
STRINGi10090.ENSMUSP00000125915

Structurei

3D structure databases

ProteinModelPortaliQ9DCX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 81Interaction with MAD2L1By similarityAdd BLAST33

Sequence similaritiesi

Belongs to the MAD2L1BP family.Curated

Phylogenomic databases

eggNOGiENOG410IEGA Eukaryota
ENOG4111KKB LUCA
GeneTreeiENSGT00390000003812
HOVERGENiHBG052442
InParanoidiQ9DCX1
OMAiPFCPRDC
OrthoDBiEOG091G113C
PhylomeDBiQ9DCX1
TreeFamiTF331730

Family and domain databases

InterProiView protein in InterPro
IPR009511 MAD1/Cdc20-bound-Mad2-bd
PfamiView protein in Pfam
PF06581 p31comet, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DCX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASGEEDMS ELSPAAAPNL DWYEKPEETH APEVDLETVI PPAQEPSNPA
60 70 80 90 100
EPFCPRDLVP VVFPGPVSQE DCCQFTCELL KHILYQRHQL PLPYEQLKHF
110 120 130 140 150
YRKVPQAEDT ARKKAWLATE ARNRKCQQAL AELESVLSHL RDFFARTLVP
160 170 180 190 200
QVLILLGGNA LSPKEFYELD LSRLAPFGVD QGLNTAACLR RLFRAIFLAD
210 220 230 240 250
PFSELQTPPL MGTIVMVQGH RDCGEDWFQP KLNYRVPSRG HKLTVTLSCG
260 270
RPSVPAMASE DYIWFQAPVT LKGFHE
Length:276
Mass (Da):31,140
Last modified:April 26, 2004 - v2
Checksum:i27C05DEBFD78D20D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51 – 52EP → DA in BAB22054 (PubMed:16141072).Curated2
Sequence conflicti104V → A in AAH05768 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002377 mRNA Translation: BAB22054.1
AK004224 mRNA Translation: BAB23226.1
BC005768 mRNA Translation: AAH05768.1
CCDSiCCDS28821.1
RefSeqiNP_079925.2, NM_025649.3
UniGeneiMm.272024

Genome annotation databases

EnsembliENSMUST00000171172; ENSMUSP00000125915; ENSMUSG00000034509
GeneIDi66591
KEGGimmu:66591
UCSCiuc008cru.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002377 mRNA Translation: BAB22054.1
AK004224 mRNA Translation: BAB23226.1
BC005768 mRNA Translation: AAH05768.1
CCDSiCCDS28821.1
RefSeqiNP_079925.2, NM_025649.3
UniGeneiMm.272024

3D structure databases

ProteinModelPortaliQ9DCX1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211577, 30 interactors
IntActiQ9DCX1, 32 interactors
MINTiQ9DCX1
STRINGi10090.ENSMUSP00000125915

PTM databases

PhosphoSitePlusiQ9DCX1

Proteomic databases

EPDiQ9DCX1
MaxQBiQ9DCX1
PaxDbiQ9DCX1
PeptideAtlasiQ9DCX1
PRIDEiQ9DCX1

Protocols and materials databases

DNASUi66591
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000171172; ENSMUSP00000125915; ENSMUSG00000034509
GeneIDi66591
KEGGimmu:66591
UCSCiuc008cru.2 mouse

Organism-specific databases

CTDi9587
MGIiMGI:1913841 Mad2l1bp

Phylogenomic databases

eggNOGiENOG410IEGA Eukaryota
ENOG4111KKB LUCA
GeneTreeiENSGT00390000003812
HOVERGENiHBG052442
InParanoidiQ9DCX1
OMAiPFCPRDC
OrthoDBiEOG091G113C
PhylomeDBiQ9DCX1
TreeFamiTF331730

Miscellaneous databases

PROiPR:Q9DCX1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034509 Expressed in 248 organ(s), highest expression level in embryo
CleanExiMM_MAD2L1BP
GenevisibleiQ9DCX1 MM

Family and domain databases

InterProiView protein in InterPro
IPR009511 MAD1/Cdc20-bound-Mad2-bd
PfamiView protein in Pfam
PF06581 p31comet, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMD2BP_MOUSE
AccessioniPrimary (citable) accession number: Q9DCX1
Secondary accession number(s): Q99J05, Q9D0Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: November 7, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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