UniProtKB - Q9DCW4 (ETFB_MOUSE)

BLAST

>sp|Q9DCW4|ETFB_MOUSE Electron transfer flavoprotein subunit beta OS=Mus musculus OX=10090 GN=Etfb PE=1 SV=3
MAELRALVAVKRVIDFAVKIRVKPDKSGVVTDGVKHSMNPFCEIAVEEAVRLKEKKLVKE
IIAVSCGPSQCQETIRTALAMGADRGIHVEIPGAQAESLGPLQVARVLAKLAEKEKVDLL
FLGKQAIDDDCNQTGQMTAGLLDWPQGTFASQVTLEGDKVKVEREIDGGLETLRLKLPAV
VTADLRLNEPRYATLPNIMKAKKKKIEVVKAGDLGVDLTSKVSVISVEEPPQRSAGVKVE
TTEDLVAKLKEVGRI

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History
Entry version 141 (12 Sep 2018)
Sequence version 3 (23 Jan 2007)
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Protein

Electron transfer flavoprotein subunit beta

Gene

Etfb

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (By similarity). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:25023281). ETFB binds an AMP molecule that probably has a purely structural role (By similarity).By similarity1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	9	AMP; via carbonyl oxygenBy similarity		1
Binding siteⁱ	66	AMP; via amide nitrogen and carbonyl oxygenBy similarity		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	39 – 42	AMPBy similarity		4
Nucleotide bindingⁱ	123 – 134	AMPBy similarityAdd BLAST		12

GO - Molecular functionⁱ

electron transfer activity Source: UniProtKB
nucleotide binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fatty acid beta-oxidation using acyl-CoA dehydrogenase
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25023281

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Electron transport, Transport
Ligand	Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-611105 Respiratory electron transport R-MMU-8876725 Protein methylation

Reactomeⁱ

R-MMU-611105 Respiratory electron transport
R-MMU-8876725 Protein methylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Electron transfer flavoprotein subunit betaCurated Short name: Beta-ETFBy similarity
Gene namesⁱ	Name:EtfbImported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:106098 Etfb

Keywords - Cellular componentⁱ

Mitochondrion

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000167871	2 – 255	Electron transfer flavoprotein subunit betaAdd BLAST		254

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanine1 Publication	1
Modified residueⁱ	200	N6,N6,N6-trimethyllysine; by ETFBKMT; alternate1 Publication	1
Modified residueⁱ	200	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	200	N6-methyllysine; alternateBy similarity	1
Modified residueⁱ	203	N6,N6,N6-trimethyllysine; by ETFBKMT1 Publication	1
Modified residueⁱ	210	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	210	N6-succinyllysine; alternateCombined sources	1
Modified residueⁱ	223	PhosphoserineBy similarity	1
Modified residueⁱ	226	PhosphoserineBy similarity	1
Modified residueⁱ	238	N6-acetyllysineCombined sources	1
Modified residueⁱ	248	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	248	N6-succinyllysine; alternateCombined sources	1

Post-translational modificationⁱ

Methylated (PubMed:25023281). Trimethylation at Lys-200 and Lys-203 may negatively regulate the activity in electron transfer from acyl-CoA dehydrogenases.By similarity1 Publication

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9DCW4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9DCW4
PaxDbⁱ	Q9DCW4
PeptideAtlas More...PeptideAtlasⁱ	Q9DCW4
PRIDEⁱ	Q9DCW4
TopDownProteomicsⁱ	Q9DCW4

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	Q9DCW4

REPRODUCTION-2DPAGEⁱ

Q9DCW4

PTM databases

iPTMnetⁱ	Q9DCW4
PhosphoSitePlusⁱ	Q9DCW4
SwissPalmⁱ	Q9DCW4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000004610 Expressed in 35 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasⁱ	Q9DCW4 baseline and differential
Genevisibleⁱ	Q9DCW4 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer composed of ETFA and ETFB. Identified in a complex that contains ETFA, ETFB and ETFRF1. Interacts with ACADM.By similarity

Protein-protein interaction databases

BioGridⁱ	225938, 4 interactors
ComplexPortalⁱ	CPX-865 Electron transfer flavoprotein complex
IntActⁱ	Q9DCW4, 8 interactors
Molecular INTeraction database More...MINTⁱ	Q9DCW4
STRINGⁱ	10090.ENSMUSP00000004729

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9DCW4
SMRⁱ	Q9DCW4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	183 – 205	Recognition loopBy similarityAdd BLAST		23

Domainⁱ

The recognition loop recognizes a hydrophobic patch at the surface of interacting dehydrogenases and acts as a static anchor at the interface.By similarity

Sequence similaritiesⁱ

Belongs to the ETF beta-subunit/FixA family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3180 Eukaryota COG2086 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009936
HOGENOMⁱ	HOG000247877
HOVERGENⁱ	HBG005614
InParanoidⁱ	Q9DCW4
KEGG Orthology (KO) More...KOⁱ	K03521
OMAⁱ	RIPNMRG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KHH
PhylomeDBⁱ	Q9DCW4
TreeFamⁱ	TF314039

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01714 ETF_beta, 1 hit
Gene3Dⁱ	3.40.50.620, 1 hit
InterProⁱ	View protein in InterPro IPR000049 ET-Flavoprotein_bsu_CS IPR014730 ETF_a/b_N IPR012255 ETF_b IPR033948 ETF_beta_N IPR014729 Rossmann-like_a/b/a_fold
PANTHERⁱ	PTHR21294 PTHR21294, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01012 ETF, 1 hit
PIRSFⁱ	PIRSF000090 Beta-ETF, 1 hit
SMARTⁱ	View protein in SMART SM00893 ETF, 1 hit
PROSITEⁱ	View protein in PROSITE PS01065 ETF_BETA, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q9DCW4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAELRALVAV KRVIDFAVKI RVKPDKSGVV TDGVKHSMNP FCEIAVEEAV 
        60         70         80         90        100
RLKEKKLVKE IIAVSCGPSQ CQETIRTALA MGADRGIHVE IPGAQAESLG 
       110        120        130        140        150
PLQVARVLAK LAEKEKVDLL FLGKQAIDDD CNQTGQMTAG LLDWPQGTFA 
       160        170        180        190        200
SQVTLEGDKV KVEREIDGGL ETLRLKLPAV VTADLRLNEP RYATLPNIMK 
       210        220        230        240        250
AKKKKIEVVK AGDLGVDLTS KVSVISVEEP PQRSAGVKVE TTEDLVAKLK 

EVGRI

Length:255

Mass (Da):27,623

Last modified:January 23, 2007 - v3

Checksum:ⁱ89E7100B327822FF

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0U1RNP5	A0A0U1RNP5_MOUSE	Electron transfer flavoprotein subu... Electron transfer flavoprotein subunit beta	Etfb	213	Annotation score:
A0A0U1RNR3	A0A0U1RNR3_MOUSE	Electron transfer flavoprotein subu... Electron transfer flavoprotein subunit beta	Etfb	177	Annotation score:
A0A0U1RNK9	A0A0U1RNK9_MOUSE	Electron transfer flavoprotein subu... Electron transfer flavoprotein subunit beta	Etfb	177	Annotation score:
A0A0U1RQB4	A0A0U1RQB4_MOUSE	Electron transfer flavoprotein subu... Electron transfer flavoprotein subunit beta	Etfb	100	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	2 – 4	Missing in BAB22076 (PubMed:16141072).Curated		3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK002407 mRNA Translation: BAB22076.1 AK150293 mRNA Translation: BAE29447.1 BC069877 mRNA Translation: AAH69877.1 BC049237 mRNA Translation: AAH49237.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21171.1
NCBI Reference Sequences More...RefSeqⁱ	NP_080971.2, NM_026695.3
UniGeneⁱ	Mm.30200

Genome annotation databases

Ensemblⁱ	ENSMUST00000004729; ENSMUSP00000004729; ENSMUSG00000004610
GeneIDⁱ	110826
KEGGⁱ	mmu:110826
UCSC genome browser More...UCSCⁱ	uc009gmt.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9DCW4	Electron transfer flavoprotein subunit beta (Fragment)		MOUSE		177	UniRef100_Q9DCW4

Protein	Similar proteins		Species	Score	Length	Source
Q9DCW4	Electron transfer flavoprotein subunit beta		RAT		255	UniRef90_Q9DCW4
Electron transfer flavoprotein subunit beta (Fragment)		MOUSE		177
Electron transfer flavoprotein subunit beta		CRIGR		255
Electron transfer flavoprotein subunit beta isoform 1		HETGA		255
Uncharacterized protein		CAVPO		255
+20

Protein	Similar proteins		Species	Score	Length	Source
Q9DCW4	Electron transfer flavoprotein subunit beta, mitochondrial		ARATH		251	UniRef50_Q9LSW8
Electron transfer flavoprotein subunit beta		RAT		255
Electron transfer flavoprotein subunit beta, mitochondrial		NOCCA		251
Uncharacterized protein		Brassica oleracea var. oleracea		251
Uncharacterized protein		ARAAL		251
+143

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK002407 mRNA Translation: BAB22076.1 AK150293 mRNA Translation: BAE29447.1 BC069877 mRNA Translation: AAH69877.1 BC049237 mRNA Translation: AAH49237.1
CCDSⁱ	CCDS21171.1
RefSeqⁱ	NP_080971.2, NM_026695.3
UniGeneⁱ	Mm.30200

3D structure databases

ProteinModelPortalⁱ	Q9DCW4
SMRⁱ	Q9DCW4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	225938, 4 interactors
ComplexPortalⁱ	CPX-865 Electron transfer flavoprotein complex
IntActⁱ	Q9DCW4, 8 interactors
MINTⁱ	Q9DCW4
STRINGⁱ	10090.ENSMUSP00000004729

PTM databases

iPTMnetⁱ	Q9DCW4
PhosphoSitePlusⁱ	Q9DCW4
SwissPalmⁱ	Q9DCW4

2D gel databases

REPRODUCTION-2DPAGEⁱ	Q9DCW4

REPRODUCTION-2DPAGEⁱ

Q9DCW4

Proteomic databases

EPDⁱ	Q9DCW4
MaxQBⁱ	Q9DCW4
PaxDbⁱ	Q9DCW4
PeptideAtlasⁱ	Q9DCW4
PRIDEⁱ	Q9DCW4
TopDownProteomicsⁱ	Q9DCW4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000004729; ENSMUSP00000004729; ENSMUSG00000004610
GeneIDⁱ	110826
KEGGⁱ	mmu:110826
UCSCⁱ	uc009gmt.2 mouse

Organism-specific databases

CTDⁱ	2109
MGIⁱ	MGI:106098 Etfb

Phylogenomic databases

eggNOGⁱ	KOG3180 Eukaryota COG2086 LUCA
GeneTreeⁱ	ENSGT00390000009936
HOGENOMⁱ	HOG000247877
HOVERGENⁱ	HBG005614
InParanoidⁱ	Q9DCW4
KOⁱ	K03521
OMAⁱ	RIPNMRG
OrthoDBⁱ	EOG091G0KHH
PhylomeDBⁱ	Q9DCW4
TreeFamⁱ	TF314039

Enzyme and pathway databases

Reactomeⁱ	R-MMU-611105 Respiratory electron transport R-MMU-8876725 Protein methylation

Reactomeⁱ

R-MMU-611105 Respiratory electron transport
R-MMU-8876725 Protein methylation

Miscellaneous databases

ChiTaRSⁱ	Etfb mouse
Protein Ontology More...PROⁱ	PR:Q9DCW4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000004610 Expressed in 35 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasⁱ	Q9DCW4 baseline and differential
Genevisibleⁱ	Q9DCW4 MM

Family and domain databases

CDDⁱ	cd01714 ETF_beta, 1 hit
Gene3Dⁱ	3.40.50.620, 1 hit
InterProⁱ	View protein in InterPro IPR000049 ET-Flavoprotein_bsu_CS IPR014730 ETF_a/b_N IPR012255 ETF_b IPR033948 ETF_beta_N IPR014729 Rossmann-like_a/b/a_fold
PANTHERⁱ	PTHR21294 PTHR21294, 1 hit
Pfamⁱ	View protein in Pfam PF01012 ETF, 1 hit
PIRSFⁱ	PIRSF000090 Beta-ETF, 1 hit
SMARTⁱ	View protein in SMART SM00893 ETF, 1 hit
PROSITEⁱ	View protein in PROSITE PS01065 ETF_BETA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ETFB_MOUSE
Accessionⁱ	Q9DCW4Primary (citable) accession number: Q9DCW4 Secondary accession number(s): Q810V3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9DCW4 (ETFB_MOUSE)

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Electron transfer flavoprotein subunit beta

Etfb

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Cytosol

Mitochondrion

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ