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Protein

Keratin, type II cytoskeletal 7

Gene

Krt7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Blocks interferon-dependent interphase and stimulates DNA synthesis in cells.By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei337StutterSequence analysis1

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 7
Alternative name(s):
Cytokeratin-7
Short name:
CK-7
Keratin-7
Short name:
K7
Type-II keratin Kb7
Gene namesi
Name:Krt7Imported
Synonyms:Krt2-7Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96704 Krt7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003076352 – 457Keratin, type II cytoskeletal 7Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei15Dimethylated arginine; alternateBy similarity1
Modified residuei15Omega-N-methylarginine; alternateBy similarity1
Modified residuei47PhosphoserineBy similarity1
Modified residuei65PhosphoserineBy similarity1
Modified residuei91PhosphothreonineBy similarity1
Cross-linki124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei173N6-acetyllysineBy similarity1
Modified residuei211PhosphoserineCombined sources1
Modified residuei246PhosphoserineBy similarity1
Modified residuei248PhosphoserineCombined sources1
Cross-linki259Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei283PhosphothreonineBy similarity1
Cross-linki290Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki325Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Arg-15 is dimethylated, probably to asymmetric dimethylarginine.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9DCV7
PeptideAtlasiQ9DCV7
PRIDEiQ9DCV7

PTM databases

iPTMnetiQ9DCV7
PhosphoSitePlusiQ9DCV7

Expressioni

Tissue specificityi

Expressed in most simple epithelia tested including liver, lactating mammary gland, lung, kidney, stomach, duodenum, colon, oviduct, uterus, pancreas, epididymis, prostate, preputial gland and mesothelium, and in most stratified epithelia tested including dorsal skin, paw/toe, tail, tongue, cervix, forestomach, and bladder. Also expressed in Henle layer of the inner root sheath of whisker follicle.1 Publication

Gene expression databases

BgeeiENSMUSG00000023039
CleanExiMM_KRT7
ExpressionAtlasiQ9DCV7 baseline and differential
GenevisibleiQ9DCV7 MM

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10. Interacts with GPER1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi225484, 2 interactors
IntActiQ9DCV7, 4 interactors
MINTiQ9DCV7
STRINGi10090.ENSMUSP00000069900

Structurei

3D structure databases

ProteinModelPortaliQ9DCV7
SMRiQ9DCV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 397IF rodPROSITE-ProRule annotationAdd BLAST313

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 84HeadSequence analysisAdd BLAST83
Regioni84 – 120Coil 1ASequence analysisAdd BLAST37
Regioni121 – 138Linker 1Sequence analysisAdd BLAST18
Regioni139 – 230Coil 1BSequence analysisAdd BLAST92
Regioni231 – 254Linker 12Sequence analysisAdd BLAST24
Regioni255 – 393Coil 2Sequence analysisAdd BLAST139
Regioni394 – 457TailSequence analysisAdd BLAST64

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R Eukaryota
ENOG410YY6B LUCA
GeneTreeiENSGT00760000118796
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ9DCV7
KOiK07605
OMAiPGIFEAQ
OrthoDBiEOG091G09KR
PhylomeDBiQ9DCV7
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DCV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIHFSSRST AYPGRGAQVR LSSGRASFGS RSLYGLGSSR PRVAVRSAYG
60 70 80 90 100
GPVGAGIREI TINQSLLAPL SVDIDPTIQQ VRQEEREQIK TLNNKFASFI
110 120 130 140 150
DKVRFLEQQN KMLETKWALL QEQKSAKSSQ LPRIFEAQIA GLRQQLETLQ
160 170 180 190 200
LDGGRLEVEL RNMQDVVEDF KNKYEEEINR RTAAENEFVL LKKDVDAAYT
210 220 230 240 250
NKVELEAKAD SLQDEINFLK TLHETELAEL QSQISDTSVV LSMDNSRSLD
260 270 280 290 300
LDGIIADVKA QYEEMANHSR AEAEAWYQTK FETLQAQAGK HGDDLRNTRN
310 320 330 340 350
EIAEMNRSIQ RLQAEIDTLK NQRAKLESSI AEAEEQGELA IKDAHAKQGE
360 370 380 390 400
LEAALQKAKQ DVARQLREYQ ELLNTKLALD IEIATYRKLL EGEESRLSGD
410 420 430 440 450
GMGPVNISVV NSTGGNGGKL IFGGTMGSNA LSFSGGPGAL RAYSIKTTST

TRRGTHN
Length:457
Mass (Da):50,709
Last modified:June 1, 2001 - v1
Checksum:iD6AD866E4949DEF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF509888 mRNA Translation: AAN64032.1
AF509890 Genomic DNA Translation: AAN64034.1
AK002434 mRNA Translation: BAB22099.1
AK137217 mRNA Translation: BAE23275.1
AK146914 mRNA Translation: BAE27526.1
BC030403 mRNA Translation: AAH30403.1
CCDSiCCDS27851.1
RefSeqiNP_149064.1, NM_033073.3
UniGeneiMm.486285

Genome annotation databases

EnsembliENSMUST00000068904; ENSMUSP00000069900; ENSMUSG00000023039
GeneIDi110310
KEGGimmu:110310
UCSCiuc007xtd.2 mouse

Similar proteinsi

Entry informationi

Entry nameiK2C7_MOUSE
AccessioniPrimary (citable) accession number: Q9DCV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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