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Entry version 136 (29 Sep 2021)
Sequence version 2 (16 Aug 2005)
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Protein

Regulator of microtubule dynamics protein 1

Gene

Rmdn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of microtubule dynamics protein 1
Short name:
RMD-1
Short name:
mRMD-1
Alternative name(s):
Microtubule-associated protein
Protein FAM82B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rmdn1
Synonyms:Fam82b
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1913552, Rmdn1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000028229

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001871831 – 305Regulator of microtubule dynamics protein 1Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei160N6-succinyllysineCombined sources1
Modified residuei245N6-succinyllysineCombined sources1

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9DCV4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9DCV4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9DCV4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9DCV4

PeptideAtlas

More...
PeptideAtlasi
Q9DCV4

PRoteomics IDEntifications database

More...
PRIDEi
Q9DCV4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
299834

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9DCV4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9DCV4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9DCV4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028229, Expressed in brown adipose tissue and 283 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9DCV4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9DCV4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with microtubules.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000029888

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9DCV4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9DCV4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati163 – 199TPR 1Add BLAST37
Repeati217 – 253TPR 2Add BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RMDN family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSJV, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182992

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_046369_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9DCV4

Identification of Orthologs from Complete Genome Data

More...
OMAi
KDVEILW

Database of Orthologous Groups

More...
OrthoDBi
1380644at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9DCV4

TreeFam database of animal gene trees

More...
TreeFami
TF315854

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011990, TPR-like_helical_dom_sf

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9DCV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALSSRLWRR LPPLRVCQQT RTWGSRGRCG AWGVRACEVI GNTRPFKRGF
60 70 80 90 100
LFSALSYLGF ETYQIISQAA VVHATAKVEE ILAQADYLYE SGETEKLYQL
110 120 130 140 150
LIQYKESEDG ELLWRLARAS RDIAQLSKTS EEEKKVLVYE ALDYAKRALE
160 170 180 190 200
KKESSSAAHK WYAICISDVG DYEGIKVKIA NAYVIKEHFE KAIELNPKDA
210 220 230 240 250
TSIHLMGIWC YTFAEMPWYQ RRIAKVLFAN PPSSTYEEAL RYFHKAEEVD
260 270 280 290 300
PNFYSKNLLL LGKTYLKLNN KKLAAFWLVK AKGYPAHTEE DKQIQTEAAQ

LLTGL
Length:305
Mass (Da):35,000
Last modified:August 16, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i692F349733A5FA8D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AGJ2A2AGJ2_MOUSE
Regulator of microtubule dynamics p...
Rmdn1 Fam82b
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24G → S in AAH25158 (PubMed:19468303).Curated1
Sequence conflicti24G → S in AAH96046 (PubMed:19468303).Curated1
Sequence conflicti31A → R in BAB26924 (PubMed:16141072).Curated1
Sequence conflicti32W → R in BAB22104 (PubMed:16141072).Curated1
Sequence conflicti282K → R in BAB22104 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK002442 mRNA Translation: BAB22104.1
AK010421 mRNA Translation: BAB26924.2
AK029446 mRNA Translation: BAC26453.1
AL683894 Genomic DNA No translation available.
BC025158 mRNA Translation: AAH25158.1
BC096046 mRNA Translation: AAH96046.1
BR000693 mRNA Translation: FAA00418.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17992.1

NCBI Reference Sequences

More...
RefSeqi
NP_079752.3, NM_025476.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000029888; ENSMUSP00000029888; ENSMUSG00000028229

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
66302

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:66302

UCSC genome browser

More...
UCSCi
uc008sca.3, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002442 mRNA Translation: BAB22104.1
AK010421 mRNA Translation: BAB26924.2
AK029446 mRNA Translation: BAC26453.1
AL683894 Genomic DNA No translation available.
BC025158 mRNA Translation: AAH25158.1
BC096046 mRNA Translation: AAH96046.1
BR000693 mRNA Translation: FAA00418.1
CCDSiCCDS17992.1
RefSeqiNP_079752.3, NM_025476.6

3D structure databases

SMRiQ9DCV4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029888

PTM databases

iPTMnetiQ9DCV4
PhosphoSitePlusiQ9DCV4
SwissPalmiQ9DCV4

Proteomic databases

EPDiQ9DCV4
jPOSTiQ9DCV4
MaxQBiQ9DCV4
PaxDbiQ9DCV4
PeptideAtlasiQ9DCV4
PRIDEiQ9DCV4
ProteomicsDBi299834

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
12639, 138 antibodies

The DNASU plasmid repository

More...
DNASUi
66302

Genome annotation databases

EnsembliENSMUST00000029888; ENSMUSP00000029888; ENSMUSG00000028229
GeneIDi66302
KEGGimmu:66302
UCSCiuc008sca.3, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51115
MGIiMGI:1913552, Rmdn1
VEuPathDBiHostDB:ENSMUSG00000028229

Phylogenomic databases

eggNOGiENOG502QSJV, Eukaryota
GeneTreeiENSGT00950000182992
HOGENOMiCLU_046369_1_1_1
InParanoidiQ9DCV4
OMAiKDVEILW
OrthoDBi1380644at2759
PhylomeDBiQ9DCV4
TreeFamiTF315854

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
66302, 1 hit in 62 CRISPR screens

Protein Ontology

More...
PROi
PR:Q9DCV4
RNActiQ9DCV4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028229, Expressed in brown adipose tissue and 283 other tissues
ExpressionAtlasiQ9DCV4, baseline and differential
GenevisibleiQ9DCV4, MM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011990, TPR-like_helical_dom_sf
SUPFAMiSSF48452, SSF48452, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRMD1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9DCV4
Secondary accession number(s): A2AGJ3
, A9UN01, Q8C0Y9, Q8R166, Q9CWS6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: September 29, 2021
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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