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Protein

39S ribosomal protein L4, mitochondrial

Gene

Mrpl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L4, mitochondrial
Short name:
L4mt
Short name:
MRP-L4
Gene namesi
Name:Mrpl4
ORF Names:MNCb-3848
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2137210 Mrpl4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002389501 – 29439S ribosomal protein L4, mitochondrialAdd BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ9DCU6
MaxQBiQ9DCU6
PaxDbiQ9DCU6
PeptideAtlasiQ9DCU6
PRIDEiQ9DCU6

PTM databases

PhosphoSitePlusiQ9DCU6

Expressioni

Gene expression databases

BgeeiENSMUSG00000003299 Expressed in 291 organ(s), highest expression level in cardiac ventricle
CleanExiMM_MRPL4
ExpressionAtlasiQ9DCU6 baseline and differential
GenevisibleiQ9DCU6 MM

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.By similarity

Protein-protein interaction databases

BioGridi211261, 1 interactor
IntActiQ9DCU6, 1 interactor
MINTiQ9DCU6
STRINGi10090.ENSMUSP00000003386

Structurei

3D structure databases

ProteinModelPortaliQ9DCU6
SMRiQ9DCU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1624 Eukaryota
COG0088 LUCA
GeneTreeiENSGT00390000014512
HOGENOMiHOG000248767
HOVERGENiHBG083638
InParanoidiQ9DCU6
KOiK02926
OMAiWIENTDA
OrthoDBiEOG091G0N0R
PhylomeDBiQ9DCU6
TreeFamiTF313913

Family and domain databases

Gene3Di3.40.1370.10, 1 hit
HAMAPiMF_01328_B Ribosomal_L4_B, 1 hit
InterProiView protein in InterPro
IPR002136 Ribosomal_L4/L1e
IPR023574 Ribosomal_L4_dom_sf
IPR013005 Ribosomal_uL4/L1e
PANTHERiPTHR10746 PTHR10746, 1 hit
PfamiView protein in Pfam
PF00573 Ribosomal_L4, 1 hit
SUPFAMiSSF52166 SSF52166, 1 hit
TIGRFAMsiTIGR03953 rplD_bact, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9DCU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRLFQAASR ASLRLSGSRV IHSLAEGAER PAEISEPRDS AGLLDPVLRK
60 70 80 90 100
CELRIPVHRR PVQAWVESLR GFEQERIGLA ELHPDVFATA PRLDIVHQVA
110 120 130 140 150
IWQRNFRRIS YANTKTRAEV SGGGRKPWQQ KGSGRARHGS IRSPLWRGGG
160 170 180 190 200
VAHGPRGPTS YYYMLPMKVR ALGLKVALTV KLMQDDLHIV DSLELPTADP
210 220 230 240 250
QYLTELAQYR HWGSSVLLVD LTHEEMPKNV VAATSGLNSF NLIPAVGLNV
260 270 280 290
YSMLKHQTLV LTLPSVAFLE DKLLWQDSRY TPLYPFRLPY SDFP
Length:294
Mass (Da):33,073
Last modified:June 1, 2001 - v1
Checksum:iEED72D7728ABEB02
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1STN5A0A1L1STN5_MOUSE
39S ribosomal protein L4, mitochond...
Mrpl4
172Annotation score:
A0A1L1SU24A0A1L1SU24_MOUSE
39S ribosomal protein L4, mitochond...
Mrpl4
160Annotation score:
A0A1L1SSY9A0A1L1SSY9_MOUSE
39S ribosomal protein L4, mitochond...
Mrpl4
264Annotation score:
A0A1L1SRY8A0A1L1SRY8_MOUSE
39S ribosomal protein L4, mitochond...
Mrpl4
219Annotation score:
A0A1L1SV70A0A1L1SV70_MOUSE
39S ribosomal protein L4, mitochond...
Mrpl4
33Annotation score:

Sequence cautioni

The sequence AAH37064 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA95082 differs from that shown. Reason: Frameshift at position 120.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147R → L in BAA95082 (Ref. 2) Curated1
Sequence conflicti268F → L in BAA95082 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049634 mRNA Translation: BAB40839.1
AB041599 mRNA Translation: BAA95082.1 Frameshift.
AK002464 mRNA Translation: BAB22118.1
BC037064 mRNA Translation: AAH37064.1 Different initiation.
BC039983 mRNA Translation: AAH39983.2
BC061095 mRNA Translation: AAH61095.1
CCDSiCCDS40548.1
RefSeqiNP_075656.2, NM_023167.2
UniGeneiMm.427576

Genome annotation databases

EnsembliENSMUST00000003386; ENSMUSP00000003386; ENSMUSG00000003299
GeneIDi66163
KEGGimmu:66163
UCSCiuc009oju.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049634 mRNA Translation: BAB40839.1
AB041599 mRNA Translation: BAA95082.1 Frameshift.
AK002464 mRNA Translation: BAB22118.1
BC037064 mRNA Translation: AAH37064.1 Different initiation.
BC039983 mRNA Translation: AAH39983.2
BC061095 mRNA Translation: AAH61095.1
CCDSiCCDS40548.1
RefSeqiNP_075656.2, NM_023167.2
UniGeneiMm.427576

3D structure databases

ProteinModelPortaliQ9DCU6
SMRiQ9DCU6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211261, 1 interactor
IntActiQ9DCU6, 1 interactor
MINTiQ9DCU6
STRINGi10090.ENSMUSP00000003386

PTM databases

PhosphoSitePlusiQ9DCU6

Proteomic databases

EPDiQ9DCU6
MaxQBiQ9DCU6
PaxDbiQ9DCU6
PeptideAtlasiQ9DCU6
PRIDEiQ9DCU6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003386; ENSMUSP00000003386; ENSMUSG00000003299
GeneIDi66163
KEGGimmu:66163
UCSCiuc009oju.1 mouse

Organism-specific databases

CTDi51073
MGIiMGI:2137210 Mrpl4

Phylogenomic databases

eggNOGiKOG1624 Eukaryota
COG0088 LUCA
GeneTreeiENSGT00390000014512
HOGENOMiHOG000248767
HOVERGENiHBG083638
InParanoidiQ9DCU6
KOiK02926
OMAiWIENTDA
OrthoDBiEOG091G0N0R
PhylomeDBiQ9DCU6
TreeFamiTF313913

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Miscellaneous databases

PROiPR:Q9DCU6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003299 Expressed in 291 organ(s), highest expression level in cardiac ventricle
CleanExiMM_MRPL4
ExpressionAtlasiQ9DCU6 baseline and differential
GenevisibleiQ9DCU6 MM

Family and domain databases

Gene3Di3.40.1370.10, 1 hit
HAMAPiMF_01328_B Ribosomal_L4_B, 1 hit
InterProiView protein in InterPro
IPR002136 Ribosomal_L4/L1e
IPR023574 Ribosomal_L4_dom_sf
IPR013005 Ribosomal_uL4/L1e
PANTHERiPTHR10746 PTHR10746, 1 hit
PfamiView protein in Pfam
PF00573 Ribosomal_L4, 1 hit
SUPFAMiSSF52166 SSF52166, 1 hit
TIGRFAMsiTIGR03953 rplD_bact, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM04_MOUSE
AccessioniPrimary (citable) accession number: Q9DCU6
Secondary accession number(s): Q811L8, Q8JZU9, Q9JJB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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