UniProtKB - Q9DCS9 (NDUBA_MOUSE)
Protein
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Gene
Ndufb10
Organism
Mus musculus (Mouse)
Status
Functioni
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity
GO - Biological processi
- mitochondrial respiratory chain complex I assembly Source: UniProtKB
- oxidation-reduction process Source: UniProtKB-KW
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-611105, Respiratory electron transport R-MMU-6799198, Complex I biogenesis |
Protein family/group databases
TCDBi | 3.D.1.6.1, the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family |
Names & Taxonomyi
Protein namesi | Recommended name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10Alternative name(s): Complex I-PDSW Short name: CI-PDSW NADH-ubiquinone oxidoreductase PDSW subunit |
Gene namesi | Name:Ndufb10 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915592, Ndufb10 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity
Mitochondrion
- mitochondrial inner membrane Source: MGI
- mitochondrial respiratory chain complex I Source: UniProtKB
- mitochondrion Source: MGI
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118831 | 1 – 176 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10Add BLAST | 176 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 21 | PhosphoserineCombined sources | 1 | |
Modified residuei | 151 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9DCS9 |
jPOSTi | Q9DCS9 |
MaxQBi | Q9DCS9 |
PaxDbi | Q9DCS9 |
PeptideAtlasi | Q9DCS9 |
PRIDEi | Q9DCS9 |
PTM databases
iPTMneti | Q9DCS9 |
PhosphoSitePlusi | Q9DCS9 |
SwissPalmi | Q9DCS9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000040048, Expressed in heart and 320 other tissues |
ExpressionAtlasi | Q9DCS9, baseline and differential |
Genevisiblei | Q9DCS9, MM |
Interactioni
Subunit structurei
Complex I is composed of 45 different subunits.
By similarityProtein-protein interaction databases
BioGRIDi | 212811, 84 interactors |
ComplexPortali | CPX-266, Mitochondrial respiratory chain complex I |
CORUMi | Q9DCS9 |
IntActi | Q9DCS9, 5 interactors |
MINTi | Q9DCS9 |
STRINGi | 10090.ENSMUSP00000043543 |
Miscellaneous databases
RNActi | Q9DCS9, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9DCS9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the complex I NDUFB10 subunit family.Curated
Phylogenomic databases
eggNOGi | KOG4009, Eukaryota |
GeneTreei | ENSGT00390000006348 |
InParanoidi | Q9DCS9 |
OMAi | ITWFRET |
OrthoDBi | 1364322at2759 |
PhylomeDBi | Q9DCS9 |
TreeFami | TF105792 |
Family and domain databases
InterProi | View protein in InterPro IPR019377, NADH_UbQ_OxRdtase_su10 IPR039993, NDUFB10 |
PANTHERi | PTHR13094, PTHR13094, 1 hit |
Pfami | View protein in Pfam PF10249, NDUFB10, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9DCS9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPDSWDKDVY PEPPSRTPAP SPQTSLPNPI TYLTKAYDLV VDWPVTLVRE
60 70 80 90 100
FIERQHAKNR TYYYHRQYRR VPDITECKEG DVLCIYEAEM QWRRDFKVDQ
110 120 130 140 150
EIMNIIQERL KACQQREGEN YQQNCAKELE QFTKVTKAYQ DRYLDLGAYY
160 170
SARKCLAKQK QRMLEERKAA RQEAAA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3YUK4 | D3YUK4_MOUSE | Complex I-PDSW | Ndufb10 | 149 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002517 mRNA Translation: BAB22156.1 AK151404 mRNA Translation: BAE30371.1 BC031664 mRNA Translation: AAH31664.1 BC043013 mRNA Translation: AAH43013.1 |
CCDSi | CCDS28494.1 |
RefSeqi | NP_080960.1, NM_026684.2 |
Genome annotation databases
Ensembli | ENSMUST00000045602; ENSMUSP00000043543; ENSMUSG00000040048 |
GeneIDi | 68342 |
KEGGi | mmu:68342 |
UCSCi | uc008ayd.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002517 mRNA Translation: BAB22156.1 AK151404 mRNA Translation: BAE30371.1 BC031664 mRNA Translation: AAH31664.1 BC043013 mRNA Translation: AAH43013.1 |
CCDSi | CCDS28494.1 |
RefSeqi | NP_080960.1, NM_026684.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6G2J | electron microscopy | 3.30 | p | 1-176 | [»] | |
6G72 | electron microscopy | 3.90 | p | 1-176 | [»] | |
SMRi | Q9DCS9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 212811, 84 interactors |
ComplexPortali | CPX-266, Mitochondrial respiratory chain complex I |
CORUMi | Q9DCS9 |
IntActi | Q9DCS9, 5 interactors |
MINTi | Q9DCS9 |
STRINGi | 10090.ENSMUSP00000043543 |
Protein family/group databases
TCDBi | 3.D.1.6.1, the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family |
PTM databases
iPTMneti | Q9DCS9 |
PhosphoSitePlusi | Q9DCS9 |
SwissPalmi | Q9DCS9 |
Proteomic databases
EPDi | Q9DCS9 |
jPOSTi | Q9DCS9 |
MaxQBi | Q9DCS9 |
PaxDbi | Q9DCS9 |
PeptideAtlasi | Q9DCS9 |
PRIDEi | Q9DCS9 |
Protocols and materials databases
Antibodypediai | 23340, 314 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000045602; ENSMUSP00000043543; ENSMUSG00000040048 |
GeneIDi | 68342 |
KEGGi | mmu:68342 |
UCSCi | uc008ayd.1, mouse |
Organism-specific databases
CTDi | 4716 |
MGIi | MGI:1915592, Ndufb10 |
Phylogenomic databases
eggNOGi | KOG4009, Eukaryota |
GeneTreei | ENSGT00390000006348 |
InParanoidi | Q9DCS9 |
OMAi | ITWFRET |
OrthoDBi | 1364322at2759 |
PhylomeDBi | Q9DCS9 |
TreeFami | TF105792 |
Enzyme and pathway databases
Reactomei | R-MMU-611105, Respiratory electron transport R-MMU-6799198, Complex I biogenesis |
Miscellaneous databases
BioGRID-ORCSi | 68342, 7 hits in 19 CRISPR screens |
ChiTaRSi | Ndufb10, mouse |
PROi | PR:Q9DCS9 |
RNActi | Q9DCS9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040048, Expressed in heart and 320 other tissues |
ExpressionAtlasi | Q9DCS9, baseline and differential |
Genevisiblei | Q9DCS9, MM |
Family and domain databases
InterProi | View protein in InterPro IPR019377, NADH_UbQ_OxRdtase_su10 IPR039993, NDUFB10 |
PANTHERi | PTHR13094, PTHR13094, 1 hit |
Pfami | View protein in Pfam PF10249, NDUFB10, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NDUBA_MOUSE | |
Accessioni | Q9DCS9Primary (citable) accession number: Q9DCS9 Secondary accession number(s): Q3UAE3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2003 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 134 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families