UniProtKB - Q9DCS1 (T176A_MOUSE)
Protein
Transmembrane protein 176A
Gene
Tmem176a
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Biological processi
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 176AAlternative name(s): Gene signature 188 Kidney-expressed gene 2 protein |
Gene namesi | Name:Tmem176a Synonyms:Gs188, Keg2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1913308, Tmem176a |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 60 – 80 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 92 – 112 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 122 – 142 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 204 – 224 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000279873 | 1 – 244 | Transmembrane protein 176AAdd BLAST | 244 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 42 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q9DCS1 |
PaxDbi | Q9DCS1 |
PeptideAtlasi | Q9DCS1 |
PRIDEi | Q9DCS1 |
PTM databases
iPTMneti | Q9DCS1 |
PhosphoSitePlusi | Q9DCS1 |
SwissPalmi | Q9DCS1 |
Expressioni
Tissue specificityi
Specifically expressed in lung, kidney and spleen.1 Publication
Inductioni
Up-regulated in kidney upon proteinuria.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000023367, Expressed in cortex of kidney and 312 other tissues |
ExpressionAtlasi | Q9DCS1, baseline and differential |
Genevisiblei | Q9DCS1, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000098969 |
Miscellaneous databases
RNActi | Q9DCS1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM176 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SF8T, Eukaryota |
GeneTreei | ENSGT00530000064074 |
HOGENOMi | CLU_090530_1_0_1 |
InParanoidi | Q9DCS1 |
OMAi | ASWVVQI |
OrthoDBi | 1402262at2759 |
PhylomeDBi | Q9DCS1 |
TreeFami | TF335389 |
Family and domain databases
InterProi | View protein in InterPro IPR007237, CD20-like IPR009281, TMEM176A/TMEM176B |
PANTHERi | PTHR15756, PTHR15756, 1 hit |
Pfami | View protein in Pfam PF04103, CD20, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9DCS1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTDMETAVV GKVDPEAPQP THIDVHIHQE SALAKLLLAG CSLLRIPASA
60 70 80 90 100
STQSQGSSRV LVASWVVQTV LGALSVVLGG TLYIGHYLAM YSEGAPFWTG
110 120 130 140 150
IVAMLAGAVA FLHKKRGGTC WALMRTLLVL ASFCTAVAAI VIGSRELNFY
160 170 180 190 200
WYFLGDDVCQ RDSSYGWSTM PRTTPVPEEA DRIALCIYYT SMLKTLLMSL
210 220 230 240
QAMLLGIWVL LLLASLTPVC VYIWKRFFTK AETEEKKLLG AAVI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0N4SVU8 | A0A0N4SVU8_MOUSE | Transmembrane protein 176A | Tmem176a | 230 | Annotation score: | ||
A0A0N4SUL5 | A0A0N4SUL5_MOUSE | Transmembrane protein 176A | Tmem176a | 44 | Annotation score: | ||
A0A0N4SVW3 | A0A0N4SVW3_MOUSE | Transmembrane protein 176A | Tmem176a | 41 | Annotation score: |
Sequence cautioni
The sequence BAE29671 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 218 | P → H in BAC37625 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB063313 mRNA Translation: BAB97230.1 AK002546 mRNA Translation: BAB22177.2 AK079378 mRNA Translation: BAC37625.1 AK150576 mRNA Translation: BAE29671.1 Frameshift. AK165660 mRNA Translation: BAE38322.1 CT010190 mRNA Translation: CAJ18398.1 BC010831 mRNA Translation: AAH10831.2 |
CCDSi | CCDS39482.1 |
RefSeqi | NP_001091741.1, NM_001098271.1 NP_079602.4, NM_025326.4 |
Genome annotation databases
Ensembli | ENSMUST00000101426; ENSMUSP00000098969; ENSMUSG00000023367 ENSMUST00000168406; ENSMUSP00000131775; ENSMUSG00000023367 ENSMUST00000204482; ENSMUSP00000145101; ENSMUSG00000023367 |
GeneIDi | 66058 |
KEGGi | mmu:66058 |
UCSCi | uc009bvw.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB063313 mRNA Translation: BAB97230.1 AK002546 mRNA Translation: BAB22177.2 AK079378 mRNA Translation: BAC37625.1 AK150576 mRNA Translation: BAE29671.1 Frameshift. AK165660 mRNA Translation: BAE38322.1 CT010190 mRNA Translation: CAJ18398.1 BC010831 mRNA Translation: AAH10831.2 |
CCDSi | CCDS39482.1 |
RefSeqi | NP_001091741.1, NM_001098271.1 NP_079602.4, NM_025326.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000098969 |
PTM databases
iPTMneti | Q9DCS1 |
PhosphoSitePlusi | Q9DCS1 |
SwissPalmi | Q9DCS1 |
Proteomic databases
MaxQBi | Q9DCS1 |
PaxDbi | Q9DCS1 |
PeptideAtlasi | Q9DCS1 |
PRIDEi | Q9DCS1 |
Protocols and materials databases
Antibodypediai | 2112, 108 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000101426; ENSMUSP00000098969; ENSMUSG00000023367 ENSMUST00000168406; ENSMUSP00000131775; ENSMUSG00000023367 ENSMUST00000204482; ENSMUSP00000145101; ENSMUSG00000023367 |
GeneIDi | 66058 |
KEGGi | mmu:66058 |
UCSCi | uc009bvw.1, mouse |
Organism-specific databases
CTDi | 55365 |
MGIi | MGI:1913308, Tmem176a |
Phylogenomic databases
eggNOGi | ENOG502SF8T, Eukaryota |
GeneTreei | ENSGT00530000064074 |
HOGENOMi | CLU_090530_1_0_1 |
InParanoidi | Q9DCS1 |
OMAi | ASWVVQI |
OrthoDBi | 1402262at2759 |
PhylomeDBi | Q9DCS1 |
TreeFami | TF335389 |
Miscellaneous databases
BioGRID-ORCSi | 66058, 0 hits in 17 CRISPR screens |
ChiTaRSi | Tmem176a, mouse |
PROi | PR:Q9DCS1 |
RNActi | Q9DCS1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000023367, Expressed in cortex of kidney and 312 other tissues |
ExpressionAtlasi | Q9DCS1, baseline and differential |
Genevisiblei | Q9DCS1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR007237, CD20-like IPR009281, TMEM176A/TMEM176B |
PANTHERi | PTHR15756, PTHR15756, 1 hit |
Pfami | View protein in Pfam PF04103, CD20, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | T176A_MOUSE | |
Accessioni | Q9DCS1Primary (citable) accession number: Q9DCS1 Secondary accession number(s): Q3UCE2, Q8BV92, Q8K4T0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families