Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DAZ-associated protein 2

Gene

Dazap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: MGI
  • mitogen-activated protein kinase kinase kinase binding Source: WormBase
  • protein serine/threonine kinase activator activity Source: WormBase
  • receptor tyrosine kinase binding Source: WormBase
  • WW domain binding Source: MGI

GO - Biological processi

  • positive regulation of protein serine/threonine kinase activity Source: WormBase

Names & Taxonomyi

Protein namesi
Recommended name:
DAZ-associated protein 2
Alternative name(s):
Deleted in azoospermia-associated protein 2
Proline-rich protein expressed in brain
Gene namesi
Name:Dazap2
Synonyms:Prtb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1344344 Dazap2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000797891 – 168DAZ-associated protein 2Add BLAST168

Post-translational modificationi

Ubiquitinated by SMURF2, leading to proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9DCP9
PRIDEiQ9DCP9

PTM databases

iPTMnetiQ9DCP9
PhosphoSitePlusiQ9DCP9

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in brain.2 Publications

Developmental stagei

Between E11.5 and E12.5 it is specifically expressed in the developing heart. From E13.5, expression in the heart disappears, while it become strongly expressed in the brain. Up-regulated during adhesion and differentiation to beating cardiomyocytes.1 Publication

Inductioni

By serum stimulation.1 Publication

Gene expression databases

BgeeiENSMUSG00000000346
CleanExiMM_DAZAP2
GenevisibleiQ9DCP9 MM

Interactioni

Subunit structurei

Interacts with DAZ and DAZL (By similarity). Interacts with IL17RB (By similarity). May interact with FAM168B (By similarity). Interacts with SOX6.By similarity1 Publication

GO - Molecular functioni

  • identical protein binding Source: MGI
  • mitogen-activated protein kinase kinase kinase binding Source: WormBase
  • receptor tyrosine kinase binding Source: WormBase
  • WW domain binding Source: MGI

Protein-protein interaction databases

BioGridi204844, 3 interactors
STRINGi10090.ENSMUSP00000000356

Structurei

3D structure databases

SMRiQ9DCP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 134Pro-richAdd BLAST127

Phylogenomic databases

eggNOGiENOG410IVQC Eukaryota
ENOG4111N7I LUCA
GeneTreeiENSGT00390000000685
HOGENOMiHOG000007683
HOVERGENiHBG051300
InParanoidiQ9DCP9
OMAiAYSEIYQ
OrthoDBiEOG091G18SW
PhylomeDBiQ9DCP9
TreeFamiTF329672

Family and domain databases

InterProiView protein in InterPro
IPR022730 DAZ_assoc-2
PANTHERiPTHR31638 PTHR31638, 1 hit
PfamiView protein in Pfam
PF11029 DAZAP2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DCP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSKGQYPTQ PTYPVQPPGN PVYPQTLHLP QAPPYTDAPP AYSELYRPSF
60 70 80 90 100
VHPGAATVPT MSAAFPGASL YLPMAQSVAV GPLGSTIPMA YYPVGPIYPP
110 120 130 140 150
GSAVLVEGGY DAGARFGAGA TAGNIPPPPP GCPPNAAQLA VMQGANVLVT
160
QRKGNFFMGG SDGGYTIW
Length:168
Mass (Da):17,289
Last modified:June 1, 2001 - v1
Checksum:i49EDDAA29D8E3AAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti162D → N in AAC34594 (PubMed:10373015).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085348 mRNA Translation: AAC34594.1
AK002595 mRNA Translation: BAB22216.1
AK050159 mRNA Translation: BAC34100.1
AK088916 mRNA Translation: BAC40651.1
AK132139 mRNA Translation: BAE20995.1
AK137246 mRNA Translation: BAE23285.1
AK146970 mRNA Translation: BAE27575.1
BC014808 mRNA Translation: AAH14808.1
BC083347 mRNA Translation: AAH83347.1
CCDSiCCDS27841.1
RefSeqiNP_036003.2, NM_011873.2
UniGeneiMm.486175

Genome annotation databases

EnsembliENSMUST00000000356; ENSMUSP00000000356; ENSMUSG00000000346
GeneIDi23994
KEGGimmu:23994
UCSCiuc007xrt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDAZP2_MOUSE
AccessioniPrimary (citable) accession number: Q9DCP9
Secondary accession number(s): O88675, Q3UVI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health