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Protein

Dynein light chain 4, axonemal

Gene

Dnal4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity).By similarity

GO - Molecular functioni

  • dynein intermediate chain binding Source: GO_Central
  • dynein light intermediate chain binding Source: GO_Central
  • motor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionMotor protein

Enzyme and pathway databases

ReactomeiR-MMU-177504 Retrograde neurotrophin signalling

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 4, axonemal
Gene namesi
Name:Dnal4
Synonyms:Dnalc4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1859217 Dnal4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001951371 – 105Dynein light chain 4, axonemalAdd BLAST105

Proteomic databases

MaxQBiQ9DCM4
PaxDbiQ9DCM4
PRIDEiQ9DCM4

Expressioni

Gene expression databases

BgeeiENSMUSG00000022420 Expressed in 254 organ(s), highest expression level in secondary oocyte
CleanExiMM_DNALC4
ExpressionAtlasiQ9DCM4 baseline and differential
GenevisibleiQ9DCM4 MM

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023055

Structurei

3D structure databases

ProteinModelPortaliQ9DCM4
SMRiQ9DCM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dynein light chain family.Curated

Phylogenomic databases

eggNOGiKOG3430 Eukaryota
ENOG4111NK2 LUCA
GeneTreeiENSGT00390000000378
HOGENOMiHOG000211145
HOVERGENiHBG104642
InParanoidiQ9DCM4
KOiK10412
OMAiYMFFGGN
TreeFamiTF324136

Family and domain databases

Gene3Di3.30.740.10, 1 hit
InterProiView protein in InterPro
IPR037177 DLC_sf
IPR001372 Dynein_light_chain_typ-1/2
PANTHERiPTHR11886 PTHR11886, 1 hit
PfamiView protein in Pfam
PF01221 Dynein_light, 1 hit
SMARTiView protein in SMART
SM01375 Dynein_light, 1 hit
SUPFAMiSSF54648 SSF54648, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9DCM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGETEGKKEE ADYKRLQTFP LVRHSDMPEE MRVETMELCV TACEKFSNNN
60 70 80 90 100
ESAAKMIKET MDKKFGSSWH VVIGEGFGFE ITHEVKNLLY LYFGGTLAVC

VWKCS
Length:105
Mass (Da):12,023
Last modified:June 20, 2002 - v2
Checksum:iD1043882C40306B6
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8CDT8Q8CDT8_MOUSE
Dynein light chain
Dnal4 Dnalc4, mCG_11515
139Annotation score:
A0A2R8VI05A0A2R8VI05_MOUSE
Dynein light chain
Dnal4 Dnalc4, mCG_11515
77Annotation score:
A0A2R8W6G8A0A2R8W6G8_MOUSE
Dynein light chain
Dnal4
59Annotation score:

Sequence cautioni

The sequence AK002657 differs from that shown. Reason: Frameshift at position 97.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49N → Y in AK002657 (Ref. 1) Curated1
Sequence conflicti80E → G in AK002657 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010031 mRNA Translation: BAA24153.1
AK002657 mRNA No translation available.
AK132061 mRNA Translation: BAE20966.1
BC005426 mRNA Translation: AAH05426.1
CCDSiCCDS27650.1
RefSeqiNP_059498.2, NM_017470.2
XP_006521233.1, XM_006521170.2
UniGeneiMm.288159

Genome annotation databases

EnsembliENSMUST00000023055; ENSMUSP00000023055; ENSMUSG00000022420
ENSMUST00000162713; ENSMUSP00000154848; ENSMUSG00000022420
GeneIDi54152
KEGGimmu:54152
UCSCiuc007wuj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010031 mRNA Translation: BAA24153.1
AK002657 mRNA No translation available.
AK132061 mRNA Translation: BAE20966.1
BC005426 mRNA Translation: AAH05426.1
CCDSiCCDS27650.1
RefSeqiNP_059498.2, NM_017470.2
XP_006521233.1, XM_006521170.2
UniGeneiMm.288159

3D structure databases

ProteinModelPortaliQ9DCM4
SMRiQ9DCM4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023055

Proteomic databases

MaxQBiQ9DCM4
PaxDbiQ9DCM4
PRIDEiQ9DCM4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023055; ENSMUSP00000023055; ENSMUSG00000022420
ENSMUST00000162713; ENSMUSP00000154848; ENSMUSG00000022420
GeneIDi54152
KEGGimmu:54152
UCSCiuc007wuj.2 mouse

Organism-specific databases

CTDi10126
MGIiMGI:1859217 Dnal4

Phylogenomic databases

eggNOGiKOG3430 Eukaryota
ENOG4111NK2 LUCA
GeneTreeiENSGT00390000000378
HOGENOMiHOG000211145
HOVERGENiHBG104642
InParanoidiQ9DCM4
KOiK10412
OMAiYMFFGGN
TreeFamiTF324136

Enzyme and pathway databases

ReactomeiR-MMU-177504 Retrograde neurotrophin signalling

Miscellaneous databases

ChiTaRSiDnal4 mouse
PROiPR:Q9DCM4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022420 Expressed in 254 organ(s), highest expression level in secondary oocyte
CleanExiMM_DNALC4
ExpressionAtlasiQ9DCM4 baseline and differential
GenevisibleiQ9DCM4 MM

Family and domain databases

Gene3Di3.30.740.10, 1 hit
InterProiView protein in InterPro
IPR037177 DLC_sf
IPR001372 Dynein_light_chain_typ-1/2
PANTHERiPTHR11886 PTHR11886, 1 hit
PfamiView protein in Pfam
PF01221 Dynein_light, 1 hit
SMARTiView protein in SMART
SM01375 Dynein_light, 1 hit
SUPFAMiSSF54648 SSF54648, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDNAL4_MOUSE
AccessioniPrimary (citable) accession number: Q9DCM4
Secondary accession number(s): O54793, Q3V233, Q99K65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 20, 2002
Last modified: November 7, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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