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Entry version 127 (16 Oct 2019)
Sequence version 2 (01 Mar 2003)
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Protein

Probable methyltransferase-like protein 15

Gene

Mettl15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable S-adenosyl-L-methionine-dependent methyltransferase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei119S-adenosyl-L-methionineBy similarity1
Binding sitei146S-adenosyl-L-methionine; via amide nitrogenBy similarity1
Binding sitei169S-adenosyl-L-methionineBy similarity1
Binding sitei176S-adenosyl-L-methionineBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable methyltransferase-like protein 15 (EC:2.1.1.-)
Alternative name(s):
Methyltransferase 5 domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mettl15
Synonyms:Mett5d1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924144 Mettl15

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003083331 – 406Probable methyltransferase-like protein 15Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei358PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9DCL4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9DCL4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9DCL4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9DCL4

PeptideAtlas

More...
PeptideAtlasi
Q9DCL4

PRoteomics IDEntifications database

More...
PRIDEi
Q9DCL4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9DCL4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9DCL4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000057234 Expressed in 230 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9DCL4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9DCL4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000080337

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9DCL4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni100 – 102S-adenosyl-L-methionine bindingBy similarity3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2782 Eukaryota
COG0275 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014756

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9DCL4

Identification of Orthologs from Complete Genome Data

More...
OMAi
NPAKRTF

Database of Orthologous Groups

More...
OrthoDBi
809593at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9DCL4

TreeFam database of animal gene trees

More...
TreeFami
TF106425

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.170, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01007 16SrRNA_methyltr_H, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002903 RsmH
IPR023397 SAM-dep_MeTrfase_MraW_recog
IPR029063 SAM-dependent_MTases

The PANTHER Classification System

More...
PANTHERi
PTHR11265 PTHR11265, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01795 Methyltransf_5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335 SSF53335, 1 hit
SSF81799 SSF81799, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00006 TIGR00006, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9DCL4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRYPYFYRT YNRLFSHFVD SGASNLDVCP HTIHTAVALH TESKAVEGTA
60 70 80 90 100
LCGPQKVYSS EEKELEAMAK LHIPVMVDQV VHCLAPQKGQ VFLDMTFGSG
110 120 130 140 150
GHTRAILQKE PDVMVYALDR DPVAYAIAEQ LSRLYPTQIQ ALLGQFSQAE
160 170 180 190 200
ALLMKAGVQP GTIDGILMDL GCSSMQLDAP ERGFSLRKDG PLDMRMDGDR
210 220 230 240 250
YPDTPTASDV VNALDQQALA SILRAYGEEK HAKKIASAII QARSTYPISR
260 270 280 290 300
TQQLASIVAG AFPPSAVYAR KDLLQRSTHI ATKTFQALRI FVNNELNELY
310 320 330 340 350
AGLRTAEKFL KTGGRLVALS FHSLEDRIVK RFLLGISMTE RFNLSIRQKV
360 370 380 390 400
KQTSQLDSDQ ETEERHSVRA PLKWELIHKK VLTPEDQDVQ DNPRGRSAKL

RAAIKL
Length:406
Mass (Da):45,282
Last modified:March 1, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6910C9302AA6BDD9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AGM2A2AGM2_MOUSE
Probable methyltransferase-like pro...
Mettl15
230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti173S → P in AAI06187 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK002682 mRNA Translation: BAB22281.2
AL691430 Genomic DNA No translation available.
BX813309 Genomic DNA No translation available.
BX813328 Genomic DNA No translation available.
BC106186 mRNA Translation: AAI06187.1
BC115926 mRNA Translation: AAI15927.1
BC117549 mRNA Translation: AAI17550.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS16506.1

NCBI Reference Sequences

More...
RefSeqi
NP_084066.2, NM_029790.3
XP_006500441.1, XM_006500378.1
XP_006500442.1, XM_006500379.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000081631; ENSMUSP00000080337; ENSMUSG00000057234

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
76894

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:76894

UCSC genome browser

More...
UCSCi
uc008llv.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002682 mRNA Translation: BAB22281.2
AL691430 Genomic DNA No translation available.
BX813309 Genomic DNA No translation available.
BX813328 Genomic DNA No translation available.
BC106186 mRNA Translation: AAI06187.1
BC115926 mRNA Translation: AAI15927.1
BC117549 mRNA Translation: AAI17550.1
CCDSiCCDS16506.1
RefSeqiNP_084066.2, NM_029790.3
XP_006500441.1, XM_006500378.1
XP_006500442.1, XM_006500379.3

3D structure databases

SMRiQ9DCL4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080337

PTM databases

iPTMnetiQ9DCL4
PhosphoSitePlusiQ9DCL4

Proteomic databases

EPDiQ9DCL4
jPOSTiQ9DCL4
MaxQBiQ9DCL4
PaxDbiQ9DCL4
PeptideAtlasiQ9DCL4
PRIDEiQ9DCL4

Genome annotation databases

EnsembliENSMUST00000081631; ENSMUSP00000080337; ENSMUSG00000057234
GeneIDi76894
KEGGimmu:76894
UCSCiuc008llv.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
196074
MGIiMGI:1924144 Mettl15

Phylogenomic databases

eggNOGiKOG2782 Eukaryota
COG0275 LUCA
GeneTreeiENSGT00390000014756
InParanoidiQ9DCL4
OMAiNPAKRTF
OrthoDBi809593at2759
PhylomeDBiQ9DCL4
TreeFamiTF106425

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mettl15 mouse

Protein Ontology

More...
PROi
PR:Q9DCL4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000057234 Expressed in 230 organ(s), highest expression level in embryo
ExpressionAtlasiQ9DCL4 baseline and differential
GenevisibleiQ9DCL4 MM

Family and domain databases

Gene3Di1.10.150.170, 1 hit
HAMAPiMF_01007 16SrRNA_methyltr_H, 1 hit
InterProiView protein in InterPro
IPR002903 RsmH
IPR023397 SAM-dep_MeTrfase_MraW_recog
IPR029063 SAM-dependent_MTases
PANTHERiPTHR11265 PTHR11265, 1 hit
PfamiView protein in Pfam
PF01795 Methyltransf_5, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
SSF81799 SSF81799, 1 hit
TIGRFAMsiTIGR00006 TIGR00006, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMET15_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9DCL4
Secondary accession number(s): Q3KQI4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: October 16, 2019
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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