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UniProtKB - Q9DCK4 (ZN414_MOUSE)
Protein
Zinc finger protein 414
Gene
Znf414
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 99 – 123 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 135 – 159 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 166 – 190 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 414 |
Gene namesi | Name:Znf414 Synonyms:Zfp414 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915641, Zfp414 |
VEuPathDBi | HostDB:ENSMUSG00000073423 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000242164 | 1 – 299 | Zinc finger protein 414Add BLAST | 299 |
Proteomic databases
MaxQBi | Q9DCK4 |
PaxDbi | Q9DCK4 |
PRIDEi | Q9DCK4 |
ProteomicsDBi | 275011 [Q9DCK4-1] 275012 [Q9DCK4-2] |
PTM databases
PhosphoSitePlusi | Q9DCK4 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000073423, Expressed in submandibular gland and 248 other tissues |
ExpressionAtlasi | Q9DCK4, baseline and differential |
Genevisiblei | Q9DCK4, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000073259 |
Miscellaneous databases
RNActi | Q9DCK4, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 98 | DisorderedSequence analysisAdd BLAST | 98 | |
Regioni | 193 – 228 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 254 – 299 | DisorderedSequence analysisAdd BLAST | 46 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 7 – 21 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 65 – 83 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 193 – 207 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 270 – 289 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 99 – 123 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 135 – 159 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 166 – 190 | C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00390000006876 |
HOGENOMi | CLU_049178_0_0_1 |
InParanoidi | Q9DCK4 |
OMAi | AHLHTCS |
PhylomeDBi | Q9DCK4 |
TreeFami | TF337512 |
Family and domain databases
InterProi | View protein in InterPro IPR039882, ZN414 IPR031799, Znf-C2H2_ribbon IPR013087, Znf_C2H2_type |
PANTHERi | PTHR21695, PTHR21695, 1 hit |
Pfami | View protein in Pfam PF15909, zf-C2H2_8, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9DCK4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEEPSRPSSD TLTTVESSSG EPDKEVASPD GAAPATFSSV EEPSPNPTAM
60 70 80 90 100
PPVWDHGGPL QQVAYPASDS CQTGSTNTGV GTNEDLRLPR RRPPPGKQIP
110 120 130 140 150
CSSPGCCLSF PSVRDLAQHL RTHCPPTQSL EGKLFRCSAL SCTESFPSMQ
160 170 180 190 200
ELVAHGKLHY KPNRYFKCEN CLLRFRTHRS LFKHLHVCID HGQNPAPPPP
210 220 230 240 250
PALDKEPPVP ERPPESDPSS SLGLPFPLLE PFTSAPTGPF LPYLNPAPFG
260 270 280 290
LSPPRLRPFL AATPGPPASS TAIWKKSQGA TSSPRRPQGG SDAPSGACR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q4H9 | E9Q4H9_MOUSE | Zinc finger protein 414 | Zfp414 | 229 | Annotation score: | ||
E9Q9N0 | E9Q9N0_MOUSE | Zinc finger protein 414 | Zfp414 | 21 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019454 | 1 – 49 | Missing in isoform 2. 2 PublicationsAdd BLAST | 49 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002706 mRNA Translation: BAB22300.1 AK169869 mRNA Translation: BAE41424.1 AF528163 Genomic DNA Translation: AAO17381.1 BC038913 mRNA Translation: AAH38913.1 |
CCDSi | CCDS37568.1 [Q9DCK4-1] |
RefSeqi | NP_080988.1, NM_026712.3 [Q9DCK4-1] |
Genome annotation databases
Ensembli | ENSMUST00000073570; ENSMUSP00000073259; ENSMUSG00000073423 [Q9DCK4-1] ENSMUST00000166627; ENSMUSP00000129423; ENSMUSG00000073423 [Q9DCK4-2] |
GeneIDi | 328801 |
KEGGi | mmu:328801 |
UCSCi | uc008byw.2, mouse [Q9DCK4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002706 mRNA Translation: BAB22300.1 AK169869 mRNA Translation: BAE41424.1 AF528163 Genomic DNA Translation: AAO17381.1 BC038913 mRNA Translation: AAH38913.1 |
CCDSi | CCDS37568.1 [Q9DCK4-1] |
RefSeqi | NP_080988.1, NM_026712.3 [Q9DCK4-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000073259 |
PTM databases
PhosphoSitePlusi | Q9DCK4 |
Proteomic databases
MaxQBi | Q9DCK4 |
PaxDbi | Q9DCK4 |
PRIDEi | Q9DCK4 |
ProteomicsDBi | 275011 [Q9DCK4-1] 275012 [Q9DCK4-2] |
Protocols and materials databases
Antibodypediai | 24915, 45 antibodies from 15 providers |
Genome annotation databases
Ensembli | ENSMUST00000073570; ENSMUSP00000073259; ENSMUSG00000073423 [Q9DCK4-1] ENSMUST00000166627; ENSMUSP00000129423; ENSMUSG00000073423 [Q9DCK4-2] |
GeneIDi | 328801 |
KEGGi | mmu:328801 |
UCSCi | uc008byw.2, mouse [Q9DCK4-1] |
Organism-specific databases
CTDi | 328801 |
MGIi | MGI:1915641, Zfp414 |
VEuPathDBi | HostDB:ENSMUSG00000073423 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00390000006876 |
HOGENOMi | CLU_049178_0_0_1 |
InParanoidi | Q9DCK4 |
OMAi | AHLHTCS |
PhylomeDBi | Q9DCK4 |
TreeFami | TF337512 |
Miscellaneous databases
BioGRID-ORCSi | 328801, 2 hits in 63 CRISPR screens |
ChiTaRSi | Zfp414, mouse |
PROi | PR:Q9DCK4 |
RNActi | Q9DCK4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000073423, Expressed in submandibular gland and 248 other tissues |
ExpressionAtlasi | Q9DCK4, baseline and differential |
Genevisiblei | Q9DCK4, MM |
Family and domain databases
InterProi | View protein in InterPro IPR039882, ZN414 IPR031799, Znf-C2H2_ribbon IPR013087, Znf_C2H2_type |
PANTHERi | PTHR21695, PTHR21695, 1 hit |
Pfami | View protein in Pfam PF15909, zf-C2H2_8, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN414_MOUSE | |
Accessioni | Q9DCK4Primary (citable) accession number: Q9DCK4 Secondary accession number(s): Q8CHU9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families