UniProtKB - Q9DCK4 (ZN414_MOUSE)

BLAST

>sp|Q9DCK4|ZN414_MOUSE Zinc finger protein 414 OS=Mus musculus OX=10090 GN=Znf414 PE=2 SV=1
MEEPSRPSSDTLTTVESSSGEPDKEVASPDGAAPATFSSVEEPSPNPTAMPPVWDHGGPL
QQVAYPASDSCQTGSTNTGVGTNEDLRLPRRRPPPGKQIPCSSPGCCLSFPSVRDLAQHL
RTHCPPTQSLEGKLFRCSALSCTESFPSMQELVAHGKLHYKPNRYFKCENCLLRFRTHRS
LFKHLHVCIDHGQNPAPPPPPALDKEPPVPERPPESDPSSSLGLPFPLLEPFTSAPTGPF
LPYLNPAPFGLSPPRLRPFLAATPGPPASSTAIWKKSQGATSSPRRPQGGSDAPSGACR

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History
Entry version 117 (07 Nov 2018)
Sequence version 1 (01 Jun 2001)
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Protein

Zinc finger protein 414

Gene

Znf414

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	99 – 123	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	135 – 159	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	166 – 190	C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 414
Gene namesⁱ	Name:Znf414 Synonyms:Zfp414
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 17

Organism-specific databases

MGIⁱ	MGI:1915641 Zfp414

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000242164	1 – 299	Zinc finger protein 414Add BLAST		299

Proteomic databases

PaxDbⁱ	Q9DCK4
PRIDEⁱ	Q9DCK4

PTM databases

PhosphoSitePlusⁱ	Q9DCK4

PhosphoSitePlusⁱ

Q9DCK4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000073423 Expressed in 222 organ(s), highest expression level in submandibular gland
CleanExⁱ	MM_ZFP414
ExpressionAtlasⁱ	Q9DCK4 baseline and differential
Genevisibleⁱ	Q9DCK4 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000073259

STRINGⁱ

10090.ENSMUSP00000073259

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9DCK4
SMRⁱ	Q9DCK4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	99 – 123	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	135 – 159	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	166 – 190	C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST	25

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006876
HOGENOMⁱ	HOG000015387
HOVERGENⁱ	HBG083015
InParanoidⁱ	Q9DCK4
OMAⁱ	EGECPVF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DB2
PhylomeDBⁱ	Q9DCK4
TreeFamⁱ	TF337512

Family and domain databases

InterProⁱ	View protein in InterPro IPR039882 ZN414 IPR031799 Znf-C2H2_ribbon IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR21695 PTHR21695, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15909 zf-C2H2_8, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 2 hits PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9DCK4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEPSRPSSD TLTTVESSSG EPDKEVASPD GAAPATFSSV EEPSPNPTAM 
        60         70         80         90        100
PPVWDHGGPL QQVAYPASDS CQTGSTNTGV GTNEDLRLPR RRPPPGKQIP 
       110        120        130        140        150
CSSPGCCLSF PSVRDLAQHL RTHCPPTQSL EGKLFRCSAL SCTESFPSMQ 
       160        170        180        190        200
ELVAHGKLHY KPNRYFKCEN CLLRFRTHRS LFKHLHVCID HGQNPAPPPP 
       210        220        230        240        250
PALDKEPPVP ERPPESDPSS SLGLPFPLLE PFTSAPTGPF LPYLNPAPFG 
       260        270        280        290 
LSPPRLRPFL AATPGPPASS TAIWKKSQGA TSSPRRPQGG SDAPSGACR

Length:299

Mass (Da):31,988

Last modified:June 1, 2001 - v1

Checksum:ⁱD68D58D7D28C5DDB

Isoform 2 (identifier: Q9DCK4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-49: Missing.

« Hide

        10         20         30         40         50
MPPVWDHGGP LQQVAYPASD SCQTGSTNTG VGTNEDLRLP RRRPPPGKQI 
        60         70         80         90        100
PCSSPGCCLS FPSVRDLAQH LRTHCPPTQS LEGKLFRCSA LSCTESFPSM 
       110        120        130        140        150
QELVAHGKLH YKPNRYFKCE NCLLRFRTHR SLFKHLHVCI DHGQNPAPPP 
       160        170        180        190        200
PPALDKEPPV PERPPESDPS SSLGLPFPLL EPFTSAPTGP FLPYLNPAPF 
       210        220        230        240        250
GLSPPRLRPF LAATPGPPAS STAIWKKSQG ATSSPRRPQG GSDAPSGACR

Show »

Length:250

Mass (Da):27,029

Checksum:ⁱADFD29E99470A6CD

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9Q4H9	E9Q4H9_MOUSE	Zinc finger protein 414 Zinc finger protein 414	Zfp414	229	Annotation score:
E9Q9N0	E9Q9N0_MOUSE	Zinc finger protein 414 Zinc finger protein 414	Zfp414	21	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_019454	1 – 49	Missing in isoform 2. 2 PublicationsAdd BLAST		49

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK002706 mRNA Translation: BAB22300.1 AK169869 mRNA Translation: BAE41424.1 AF528163 Genomic DNA Translation: AAO17381.1 BC038913 mRNA Translation: AAH38913.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS37568.1 [Q9DCK4-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_080988.1, NM_026712.3 [Q9DCK4-1]
UniGeneⁱ	Mm.181488

Genome annotation databases

Ensemblⁱ	ENSMUST00000073570; ENSMUSP00000073259; ENSMUSG00000073423 [Q9DCK4-1] ENSMUST00000166627; ENSMUSP00000129423; ENSMUSG00000073423 [Q9DCK4-2]
GeneIDⁱ	328801
KEGGⁱ	mmu:328801
UCSC genome browser More...UCSCⁱ	uc008byw.2 mouse [Q9DCK4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9DCK4	MCG140116, isoform CRA_a		MOUSE		299	UniRef100_Q9DCK4
Isoform 2 of Zinc finger protein 414		MOUSE		250
Zinc finger protein 414 (Fragment)		MOUSE		229
Zinc finger protein 414 (Fragment)		MOUSE		21

Protein	Similar proteins		Species	Score	Length	Source
Q9DCK4	MCG140116, isoform CRA_a		MOUSE		299	UniRef90_Q9DCK4
UPI000A31229D		MUSPA		299
UPI000A315381		MUSCR		299
Isoform 2 of Zinc finger protein 414		MOUSE		250
Zinc finger protein 414 (Fragment)		MOUSE		229
+2

Protein	Similar proteins		Species	Score	Length	Source
Q9DCK4	MCG140116, isoform CRA_a		MOUSE		299	UniRef50_Q9DCK4
Uncharacterized protein		PANPA		278
Uncharacterized protein		CAMFR		169
zinc finger protein 414		URSMA		254
UPI000A315381		MUSCR		299
+16

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK002706 mRNA Translation: BAB22300.1 AK169869 mRNA Translation: BAE41424.1 AF528163 Genomic DNA Translation: AAO17381.1 BC038913 mRNA Translation: AAH38913.1
CCDSⁱ	CCDS37568.1 [Q9DCK4-1]
RefSeqⁱ	NP_080988.1, NM_026712.3 [Q9DCK4-1]
UniGeneⁱ	Mm.181488

3D structure databases

ProteinModelPortalⁱ	Q9DCK4
SMRⁱ	Q9DCK4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000073259

STRINGⁱ

10090.ENSMUSP00000073259

PTM databases

PhosphoSitePlusⁱ	Q9DCK4

PhosphoSitePlusⁱ

Q9DCK4

Proteomic databases

PaxDbⁱ	Q9DCK4
PRIDEⁱ	Q9DCK4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000073570; ENSMUSP00000073259; ENSMUSG00000073423 [Q9DCK4-1] ENSMUST00000166627; ENSMUSP00000129423; ENSMUSG00000073423 [Q9DCK4-2]
GeneIDⁱ	328801
KEGGⁱ	mmu:328801
UCSCⁱ	uc008byw.2 mouse [Q9DCK4-1]

Organism-specific databases

CTDⁱ	328801
MGIⁱ	MGI:1915641 Zfp414

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00390000006876
HOGENOMⁱ	HOG000015387
HOVERGENⁱ	HBG083015
InParanoidⁱ	Q9DCK4
OMAⁱ	EGECPVF
OrthoDBⁱ	EOG091G0DB2
PhylomeDBⁱ	Q9DCK4
TreeFamⁱ	TF337512

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9DCK4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000073423 Expressed in 222 organ(s), highest expression level in submandibular gland
CleanExⁱ	MM_ZFP414
ExpressionAtlasⁱ	Q9DCK4 baseline and differential
Genevisibleⁱ	Q9DCK4 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR039882 ZN414 IPR031799 Znf-C2H2_ribbon IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR21695 PTHR21695, 1 hit
Pfamⁱ	View protein in Pfam PF15909 zf-C2H2_8, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 2 hits PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN414_MOUSE
Accessionⁱ	Q9DCK4Primary (citable) accession number: Q9DCK4 Secondary accession number(s): Q8CHU9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9DCK4 (ZN414_MOUSE)

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Zinc finger protein 414

Znf414

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ