UniProtKB - Q9DCH6 (ZFAN6_MOUSE)
Protein
AN1-type zinc finger protein 6
Gene
Zfand6
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1 (By similarity). Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes.By similarity1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 8 – 42 | A20-typePROSITE-ProRule annotationAdd BLAST | 35 | |
Zinc fingeri | 161 – 204 | AN1-typePROSITE-ProRule annotationAdd BLAST | 44 |
GO - Molecular functioni
- DNA binding Source: InterPro
- polyubiquitin modification-dependent protein binding Source: UniProtKB
- zinc ion binding Source: InterPro
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cellular response to tumor necrosis factor Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- protein targeting to peroxisome Source: UniProtKB
- regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Keywordsi
Biological process | Apoptosis, Protein transport, Transport |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-9033241, Peroxisomal protein import |
Names & Taxonomyi
Protein namesi | Recommended name: AN1-type zinc finger protein 6Alternative name(s): Associated with PRK1 protein Zinc finger A20 domain-containing protein 3 |
Gene namesi | Name:Zfand6 Synonyms:Awp1, Za20d3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1929510, Zfand6 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 30 | C → S: Abolishes interaction with PEX6 and ubiquitin. Impairs interaction with PEX5. 1 Publication | 1 | |
Mutagenesisi | 180 | C → S: Impairs interaction with PEX6. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000245236 | 1 – 223 | AN1-type zinc finger protein 6Add BLAST | 223 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 49 | PhosphoserineBy similarity | 1 | |
Modified residuei | 219 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9DCH6 |
MaxQBi | Q9DCH6 |
PaxDbi | Q9DCH6 |
PeptideAtlasi | Q9DCH6 |
PRIDEi | Q9DCH6 |
PTM databases
iPTMneti | Q9DCH6 |
PhosphoSitePlusi | Q9DCH6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030629, Expressed in blood and 311 other tissues |
Genevisiblei | Q9DCH6, MM |
Interactioni
Subunit structurei
Interacts with PKN1.
Interacts with TRAF2 (By similarity).
Interacts with mono- and polyubiquitin.
Interacts with PEX6.
Interacts with PEX5 (Cys-linked ubiquitinated).
By similarity2 PublicationsGO - Molecular functioni
- polyubiquitin modification-dependent protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 211125, 4 interactors |
STRINGi | 10090.ENSMUSP00000069228 |
Miscellaneous databases
RNActi | Q9DCH6, protein |
Family & Domainsi
Domaini
The A20-type zinc finger domain mediates regulation of NF-kappa-B activity.By similarity
The AN1-type zinc finger domain mediates association with TRAF2.By similarity
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 8 – 42 | A20-typePROSITE-ProRule annotationAdd BLAST | 35 | |
Zinc fingeri | 161 – 204 | AN1-typePROSITE-ProRule annotationAdd BLAST | 44 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3173, Eukaryota |
GeneTreei | ENSGT00940000160833 |
HOGENOMi | CLU_057016_1_0_1 |
InParanoidi | Q9DCH6 |
OrthoDBi | 1551371at2759 |
PhylomeDBi | Q9DCH6 |
TreeFami | TF313612 |
Family and domain databases
Gene3Di | 4.10.1110.10, 1 hit |
InterProi | View protein in InterPro IPR035896, AN1-like_Znf IPR002653, Znf_A20 IPR000058, Znf_AN1 |
Pfami | View protein in Pfam PF01754, zf-A20, 1 hit PF01428, zf-AN1, 1 hit |
SMARTi | View protein in SMART SM00259, ZnF_A20, 1 hit SM00154, ZnF_AN1, 1 hit |
SUPFAMi | SSF118310, SSF118310, 1 hit |
PROSITEi | View protein in PROSITE PS51036, ZF_A20, 1 hit PS51039, ZF_AN1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q9DCH6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQETNHSQA PMLCSTGCGF YGNPRTNGMC SVCYKEHLQR QNSSNGRISP
60 70 80 90 100
PAASVSSLSE SLPVQCADGS VPDAQSALDS TSSSMQPGPV SNQSLLSESV
110 120 130 140 150
APSQVDSTSV DKAVSETEDL QGPRAEGLVP LECDPPSSVS DTTQQPSEEQ
160 170 180 190 200
SKSLEKPKQK KNRCFMCRKK VGLTGFECRC GNVYCGVHRY SDVHNCSYNY
210 220
KADAAEKIRK ENPVVVGEKI QKI
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A140LI56 | A0A140LI56_MOUSE | AN1-type zinc finger protein 6 | Zfand6 | 188 | Annotation score: | ||
A0A140LIM2 | A0A140LIM2_MOUSE | AN1-type zinc finger protein 6 | Zfand6 | 217 | Annotation score: | ||
A0A140LJF3 | A0A140LJF3_MOUSE | AN1-type zinc finger protein 6 | Zfand6 | 184 | Annotation score: | ||
A0A140LHV2 | A0A140LHV2_MOUSE | AN1-type zinc finger protein 6 | Zfand6 | 55 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 99 | S → P in CAC14886 (PubMed:11054541).Curated | 1 | |
Sequence conflicti | 190 | Y → S in CAC14886 (PubMed:11054541).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ251508 mRNA Translation: CAC14886.1 AK002775 mRNA Translation: BAB22349.1 AK144902 mRNA Translation: BAE26124.1 BC010683 mRNA Translation: AAH10683.1 |
CCDSi | CCDS21419.1 |
RefSeqi | NP_075361.2, NM_022985.6 XP_006508168.1, XM_006508105.2 XP_006508169.1, XM_006508106.2 XP_006508170.1, XM_006508107.3 XP_006508171.1, XM_006508108.1 |
Genome annotation databases
Ensembli | ENSMUST00000069537; ENSMUSP00000069228; ENSMUSG00000030629 ENSMUST00000178385; ENSMUSP00000135968; ENSMUSG00000030629 ENSMUST00000209117; ENSMUSP00000146518; ENSMUSG00000030629 |
GeneIDi | 65098 |
KEGGi | mmu:65098 |
UCSCi | uc009iek.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ251508 mRNA Translation: CAC14886.1 AK002775 mRNA Translation: BAB22349.1 AK144902 mRNA Translation: BAE26124.1 BC010683 mRNA Translation: AAH10683.1 |
CCDSi | CCDS21419.1 |
RefSeqi | NP_075361.2, NM_022985.6 XP_006508168.1, XM_006508105.2 XP_006508169.1, XM_006508106.2 XP_006508170.1, XM_006508107.3 XP_006508171.1, XM_006508108.1 |
3D structure databases
SMRi | Q9DCH6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 211125, 4 interactors |
STRINGi | 10090.ENSMUSP00000069228 |
PTM databases
iPTMneti | Q9DCH6 |
PhosphoSitePlusi | Q9DCH6 |
Proteomic databases
EPDi | Q9DCH6 |
MaxQBi | Q9DCH6 |
PaxDbi | Q9DCH6 |
PeptideAtlasi | Q9DCH6 |
PRIDEi | Q9DCH6 |
Protocols and materials databases
Antibodypediai | 15226, 100 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000069537; ENSMUSP00000069228; ENSMUSG00000030629 ENSMUST00000178385; ENSMUSP00000135968; ENSMUSG00000030629 ENSMUST00000209117; ENSMUSP00000146518; ENSMUSG00000030629 |
GeneIDi | 65098 |
KEGGi | mmu:65098 |
UCSCi | uc009iek.1, mouse |
Organism-specific databases
CTDi | 54469 |
MGIi | MGI:1929510, Zfand6 |
Phylogenomic databases
eggNOGi | KOG3173, Eukaryota |
GeneTreei | ENSGT00940000160833 |
HOGENOMi | CLU_057016_1_0_1 |
InParanoidi | Q9DCH6 |
OrthoDBi | 1551371at2759 |
PhylomeDBi | Q9DCH6 |
TreeFami | TF313612 |
Enzyme and pathway databases
Reactomei | R-MMU-9033241, Peroxisomal protein import |
Miscellaneous databases
BioGRID-ORCSi | 65098, 3 hits in 21 CRISPR screens |
ChiTaRSi | Zfand6, mouse |
PROi | PR:Q9DCH6 |
RNActi | Q9DCH6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030629, Expressed in blood and 311 other tissues |
Genevisiblei | Q9DCH6, MM |
Family and domain databases
Gene3Di | 4.10.1110.10, 1 hit |
InterProi | View protein in InterPro IPR035896, AN1-like_Znf IPR002653, Znf_A20 IPR000058, Znf_AN1 |
Pfami | View protein in Pfam PF01754, zf-A20, 1 hit PF01428, zf-AN1, 1 hit |
SMARTi | View protein in SMART SM00259, ZnF_A20, 1 hit SM00154, ZnF_AN1, 1 hit |
SUPFAMi | SSF118310, SSF118310, 1 hit |
PROSITEi | View protein in PROSITE PS51036, ZF_A20, 1 hit PS51039, ZF_AN1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFAN6_MOUSE | |
Accessioni | Q9DCH6Primary (citable) accession number: Q9DCH6 Secondary accession number(s): Q9ER79 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot