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Protein

Ribonuclease P protein subunit p20

Gene

Pop7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p20 (EC:3.1.26.5)
Short name:
RNaseP protein p20
Gene namesi
Name:Pop7
Synonyms:Rpp20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1921347 Pop7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002377011 – 140Ribonuclease P protein subunit p20Add BLAST140

Proteomic databases

EPDiQ9DCH2
MaxQBiQ9DCH2
PaxDbiQ9DCH2
PeptideAtlasiQ9DCH2
PRIDEiQ9DCH2

PTM databases

PhosphoSitePlusiQ9DCH2

Expressioni

Gene expression databases

BgeeiENSMUSG00000029715 Expressed in 259 organ(s), highest expression level in dorsal pancreas
GenevisibleiQ9DCH2 MM

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and SMN1. RPP20/POP7 is probably a dimer (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031728

Structurei

3D structure databases

ProteinModelPortaliQ9DCH2
SMRiQ9DCH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone-like Alba family.Curated

Phylogenomic databases

eggNOGiENOG410IXMT Eukaryota
ENOG4111R36 LUCA
GeneTreeiENSGT00510000048483
HOGENOMiHOG000253010
HOVERGENiHBG001490
InParanoidiQ9DCH2
KOiK14527
OMAiGQNACTE
OrthoDBiEOG091G0Y8P
PhylomeDBiQ9DCH2
TreeFamiTF313948

Family and domain databases

Gene3Di3.30.110.20, 1 hit
InterProiView protein in InterPro
IPR036882 Alba-like_dom_sf
IPR014612 Pop7/Rpp20
PANTHERiPTHR15314 PTHR15314, 1 hit
PfamiView protein in Pfam
PF12328 Rpp20, 1 hit
PIRSFiPIRSF036572 RPP20, 1 hit
SUPFAMiSSF82704 SSF82704, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DCH2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAENREPRCA IEAELDPVEY TLRKRLPHRL PRRPNDIYVN MKTDFKAQLA
60 70 80 90 100
RCQKLLDGGT RGQNACTEIY IHGLGLAINR AINIALQLQA GSFGSLQVAA
110 120 130 140
NTSTVELVDE LEPETDSREP LTRVRNNSAI HIRVFRVTPK
Length:140
Mass (Da):15,777
Last modified:June 1, 2001 - v1
Checksum:i0F30841C7F50DFA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312033 Genomic DNA Translation: AAK28826.1
AK002782 mRNA Translation: BAB22355.1
AK158620 mRNA Translation: BAE34584.1
AK162268 mRNA Translation: BAE36826.1
BC010780 mRNA Translation: AAH10780.1
CCDSiCCDS19768.1
RefSeqiNP_083029.1, NM_028753.2
UniGeneiMm.290242

Genome annotation databases

EnsembliENSMUST00000031728; ENSMUSP00000031728; ENSMUSG00000029715
ENSMUST00000111035; ENSMUSP00000106664; ENSMUSG00000029715
GeneIDi74097
KEGGimmu:74097
UCSCiuc009aco.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312033 Genomic DNA Translation: AAK28826.1
AK002782 mRNA Translation: BAB22355.1
AK158620 mRNA Translation: BAE34584.1
AK162268 mRNA Translation: BAE36826.1
BC010780 mRNA Translation: AAH10780.1
CCDSiCCDS19768.1
RefSeqiNP_083029.1, NM_028753.2
UniGeneiMm.290242

3D structure databases

ProteinModelPortaliQ9DCH2
SMRiQ9DCH2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031728

PTM databases

PhosphoSitePlusiQ9DCH2

Proteomic databases

EPDiQ9DCH2
MaxQBiQ9DCH2
PaxDbiQ9DCH2
PeptideAtlasiQ9DCH2
PRIDEiQ9DCH2

Protocols and materials databases

DNASUi74097
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031728; ENSMUSP00000031728; ENSMUSG00000029715
ENSMUST00000111035; ENSMUSP00000106664; ENSMUSG00000029715
GeneIDi74097
KEGGimmu:74097
UCSCiuc009aco.1 mouse

Organism-specific databases

CTDi10248
MGIiMGI:1921347 Pop7

Phylogenomic databases

eggNOGiENOG410IXMT Eukaryota
ENOG4111R36 LUCA
GeneTreeiENSGT00510000048483
HOGENOMiHOG000253010
HOVERGENiHBG001490
InParanoidiQ9DCH2
KOiK14527
OMAiGQNACTE
OrthoDBiEOG091G0Y8P
PhylomeDBiQ9DCH2
TreeFamiTF313948

Miscellaneous databases

PROiPR:Q9DCH2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029715 Expressed in 259 organ(s), highest expression level in dorsal pancreas
GenevisibleiQ9DCH2 MM

Family and domain databases

Gene3Di3.30.110.20, 1 hit
InterProiView protein in InterPro
IPR036882 Alba-like_dom_sf
IPR014612 Pop7/Rpp20
PANTHERiPTHR15314 PTHR15314, 1 hit
PfamiView protein in Pfam
PF12328 Rpp20, 1 hit
PIRSFiPIRSF036572 RPP20, 1 hit
SUPFAMiSSF82704 SSF82704, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPOP7_MOUSE
AccessioniPrimary (citable) accession number: Q9DCH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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