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Protein

CD302 antigen

Gene

Cd302

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
CD302 antigen
Alternative name(s):
C-type lectin domain family 13 member A
Type I transmembrane C-type lectin receptor DCL-1
CD_antigen: CD302
Gene namesi
Name:Cd302
Synonyms:Clec13a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913455 Cd302

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 165ExtracellularSequence analysisAdd BLAST145
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Topological domaini187 – 228CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000025233321 – 228CD302 antigenAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi125 ↔ 140PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9DCG2
PeptideAtlasiQ9DCG2
PRIDEiQ9DCG2

PTM databases

PhosphoSitePlusiQ9DCG2
SwissPalmiQ9DCG2

Expressioni

Gene expression databases

BgeeiENSMUSG00000060703 Expressed in 275 organ(s), highest expression level in liver
CleanExiMM_CD302
GenevisibleiQ9DCG2 MM

Structurei

3D structure databases

ProteinModelPortaliQ9DCG2
SMRiQ9DCG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 149C-type lectinPROSITE-ProRule annotationAdd BLAST120

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS40 Eukaryota
ENOG41126J3 LUCA
GeneTreeiENSGT00680000100098
HOGENOMiHOG000232049
HOVERGENiHBG080529
InParanoidiQ9DCG2
KOiK06722
OMAiEYHPPFR
OrthoDBiEOG091G0PMQ
PhylomeDBiQ9DCG2

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9DCG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPHAALSSLV LLSLATAIVA DCPSSTWVQF QGSCYAFLQV TINVENIEDV
60 70 80 90 100
RKQCTDHGAD MVSIHNEEEN AFILDTLQKR WKGPDDLLLG MFYDTDDATF
110 120 130 140 150
KWYDHSNMTF DKWADQDGED LVDTCGFLYT KTGEWRKGDC EISSVEGTLC
160 170 180 190 200
KAAIPYDKKY LSDNHILIST LVIASTVTLA VLGAIIWFLY RRNARSGFTS
210 220
FSPAPLSPYS DGCALVVAEE DEYAVQLD
Length:228
Mass (Da):25,423
Last modified:July 5, 2004 - v2
Checksum:i7482F9DB7DC9FD10
GO
Isoform 2 (identifier: Q9DCG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-163: IPYDKKYLSD → N

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):24,313
Checksum:iED4CB80C62704F7C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020910154 – 163IPYDKKYLSD → N in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002812 mRNA Translation: BAB22377.2
AK004267 mRNA Translation: BAB23242.2
AL935326 Genomic DNA Translation: CAM13633.1
AL935326 Genomic DNA Translation: CAM13634.1
CH466519 Genomic DNA Translation: EDL26959.1
CH466519 Genomic DNA Translation: EDL26960.1
BC005501 mRNA Translation: AAH05501.1
CCDSiCCDS16058.1 [Q9DCG2-2]
CCDS71058.1 [Q9DCG2-1]
RefSeqiNP_001277589.1, NM_001290660.1 [Q9DCG2-1]
NP_079698.2, NM_025422.4 [Q9DCG2-2]
UniGeneiMm.227281

Genome annotation databases

EnsembliENSMUST00000028356; ENSMUSP00000028356; ENSMUSG00000060703 [Q9DCG2-2]
ENSMUST00000074606; ENSMUSP00000074188; ENSMUSG00000060703 [Q9DCG2-1]
GeneIDi66205
KEGGimmu:66205
UCSCiuc008jub.2 mouse [Q9DCG2-2]
uc008juc.2 mouse [Q9DCG2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002812 mRNA Translation: BAB22377.2
AK004267 mRNA Translation: BAB23242.2
AL935326 Genomic DNA Translation: CAM13633.1
AL935326 Genomic DNA Translation: CAM13634.1
CH466519 Genomic DNA Translation: EDL26959.1
CH466519 Genomic DNA Translation: EDL26960.1
BC005501 mRNA Translation: AAH05501.1
CCDSiCCDS16058.1 [Q9DCG2-2]
CCDS71058.1 [Q9DCG2-1]
RefSeqiNP_001277589.1, NM_001290660.1 [Q9DCG2-1]
NP_079698.2, NM_025422.4 [Q9DCG2-2]
UniGeneiMm.227281

3D structure databases

ProteinModelPortaliQ9DCG2
SMRiQ9DCG2
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiQ9DCG2
SwissPalmiQ9DCG2

Proteomic databases

PaxDbiQ9DCG2
PeptideAtlasiQ9DCG2
PRIDEiQ9DCG2

Protocols and materials databases

DNASUi66205
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028356; ENSMUSP00000028356; ENSMUSG00000060703 [Q9DCG2-2]
ENSMUST00000074606; ENSMUSP00000074188; ENSMUSG00000060703 [Q9DCG2-1]
GeneIDi66205
KEGGimmu:66205
UCSCiuc008jub.2 mouse [Q9DCG2-2]
uc008juc.2 mouse [Q9DCG2-1]

Organism-specific databases

CTDi9936
MGIiMGI:1913455 Cd302

Phylogenomic databases

eggNOGiENOG410IS40 Eukaryota
ENOG41126J3 LUCA
GeneTreeiENSGT00680000100098
HOGENOMiHOG000232049
HOVERGENiHBG080529
InParanoidiQ9DCG2
KOiK06722
OMAiEYHPPFR
OrthoDBiEOG091G0PMQ
PhylomeDBiQ9DCG2

Miscellaneous databases

PROiPR:Q9DCG2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060703 Expressed in 275 organ(s), highest expression level in liver
CleanExiMM_CD302
GenevisibleiQ9DCG2 MM

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD302_MOUSE
AccessioniPrimary (citable) accession number: Q9DCG2
Secondary accession number(s): A2AW84
, A2AW85, Q78KD8, Q9D0X7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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