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Protein

Transmembrane protein 25

Gene

Tmem25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 25
Gene namesi
Name:Tmem25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1918937 Tmem25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 232ExtracellularSequence analysisAdd BLAST206
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 365CytoplasmicSequence analysisAdd BLAST112

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001498527 – 365Transmembrane protein 25Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 107PROSITE-ProRule annotation
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9DCF1
PRIDEiQ9DCF1

PTM databases

iPTMnetiQ9DCF1
PhosphoSitePlusiQ9DCF1

Expressioni

Gene expression databases

BgeeiENSMUSG00000002032 Expressed in 163 organ(s), highest expression level in metanephric proximal tubule
CleanExiMM_TMEM25
ExpressionAtlasiQ9DCF1 baseline and differential
GenevisibleiQ9DCF1 MM

Structurei

3D structure databases

ProteinModelPortaliQ9DCF1
SMRiQ9DCF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 123Ig-likeAdd BLAST94

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF2Y Eukaryota
ENOG410ZNWF LUCA
GeneTreeiENSGT00390000003414
HOGENOMiHOG000261622
HOVERGENiHBG057137
InParanoidiQ9DCF1
KOiK22652
OMAiPQLAWYL
OrthoDBiEOG091G0H18
PhylomeDBiQ9DCF1
TreeFamiTF333068

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9DCF1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELPLSQATL RHTLLLLPAL LSSGQGELAP QIDGQTWAER ALRENEHHAF
60 70 80 90 100
TCRVAGGSAT PRLAWYLDGQ LQEATTSRLL SVGGDAFSGG TSTFTVTAQR
110 120 130 140 150
SQHELNCSLQ DPGSGRPANA SVILNVQFKP EIAQVGAKYQ EAQGPGLLVV
160 170 180 190 200
LFALVRANPP ANVTWIDQDG PVTVNASDFL VLDAQNYPWL TNHTVQLQLR
210 220 230 240 250
SLAHNLSVVA TNDVGVTSAS LPAPGLLATR IEVPLLGIVV AGGLALGTLV
260 270 280 290 300
GFSTLVACLV CRKEKKTKGP SRRPSLISSD SNNLKLNNVR LPRENMSLPS
310 320 330 340 350
NLQLNDLTPD LRGKATERPM AQHSSRPELL EAEPGGLLTS RGFIRLPMLG
360
YIYRVSSVSS DEIWL
Length:365
Mass (Da):39,170
Last modified:June 1, 2001 - v1
Checksum:i9BE03C7945A24757
GO
Isoform 2 (identifier: Q9DCF1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     280-365: Missing.

Note: No experimental confirmation available.
Show »
Length:279
Mass (Da):29,497
Checksum:i243DF301DF89BBC0
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SVA2A0A1L1SVA2_MOUSE
Transmembrane protein 25
Tmem25
279Annotation score:
A0A1N9MYB8A0A1N9MYB8_MOUSE
Transmembrane protein 25
Tmem25
321Annotation score:
A0A1L1SQN0A0A1L1SQN0_MOUSE
Transmembrane protein 25
Tmem25
168Annotation score:
A0A1L1SU51A0A1L1SU51_MOUSE
Transmembrane protein 25
Tmem25
94Annotation score:
A0A1L1SRQ1A0A1L1SRQ1_MOUSE
Transmembrane protein 25
Tmem25
95Annotation score:
A0A1L1STM3A0A1L1STM3_MOUSE
Transmembrane protein 25
Tmem25
83Annotation score:
A0A1L1SR05A0A1L1SR05_MOUSE
Transmembrane protein 25
Tmem25
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti279S → R (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012942280 – 365Missing in isoform 2. 1 PublicationAdd BLAST86

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002841 mRNA Translation: BAB22398.1
AK165199 mRNA Translation: BAE38074.1
AK165827 mRNA Translation: BAE38398.1
BC060057 mRNA Translation: AAH60057.1
BC060243 mRNA Translation: AAH60243.1
CCDSiCCDS23120.1 [Q9DCF1-1]
RefSeqiNP_082141.1, NM_027865.2 [Q9DCF1-1]
XP_006510672.1, XM_006510609.3
XP_006510673.1, XM_006510610.3 [Q9DCF1-1]
UniGeneiMm.41409

Genome annotation databases

EnsembliENSMUST00000002100; ENSMUSP00000002100; ENSMUSG00000002032 [Q9DCF1-1]
GeneIDi71687
KEGGimmu:71687
UCSCiuc009pem.1 mouse [Q9DCF1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002841 mRNA Translation: BAB22398.1
AK165199 mRNA Translation: BAE38074.1
AK165827 mRNA Translation: BAE38398.1
BC060057 mRNA Translation: AAH60057.1
BC060243 mRNA Translation: AAH60243.1
CCDSiCCDS23120.1 [Q9DCF1-1]
RefSeqiNP_082141.1, NM_027865.2 [Q9DCF1-1]
XP_006510672.1, XM_006510609.3
XP_006510673.1, XM_006510610.3 [Q9DCF1-1]
UniGeneiMm.41409

3D structure databases

ProteinModelPortaliQ9DCF1
SMRiQ9DCF1
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9DCF1
PhosphoSitePlusiQ9DCF1

Proteomic databases

PaxDbiQ9DCF1
PRIDEiQ9DCF1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002100; ENSMUSP00000002100; ENSMUSG00000002032 [Q9DCF1-1]
GeneIDi71687
KEGGimmu:71687
UCSCiuc009pem.1 mouse [Q9DCF1-1]

Organism-specific databases

CTDi84866
MGIiMGI:1918937 Tmem25

Phylogenomic databases

eggNOGiENOG410IF2Y Eukaryota
ENOG410ZNWF LUCA
GeneTreeiENSGT00390000003414
HOGENOMiHOG000261622
HOVERGENiHBG057137
InParanoidiQ9DCF1
KOiK22652
OMAiPQLAWYL
OrthoDBiEOG091G0H18
PhylomeDBiQ9DCF1
TreeFamiTF333068

Miscellaneous databases

PROiPR:Q9DCF1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002032 Expressed in 163 organ(s), highest expression level in metanephric proximal tubule
CleanExiMM_TMEM25
ExpressionAtlasiQ9DCF1 baseline and differential
GenevisibleiQ9DCF1 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMM25_MOUSE
AccessioniPrimary (citable) accession number: Q9DCF1
Secondary accession number(s): Q3TMP3, Q6PAK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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