Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tight junction-associated protein 1

Gene

Tjap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • Golgi organization Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Tight junction-associated protein 1
Alternative name(s):
Protein incorporated later into tight junctions
Tight junction protein 4
Gene namesi
Name:Tjap1
Synonyms:Pilt, Tjp4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1921344 Tjap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Golgi apparatus, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725511 – 539Tight junction-associated protein 1Add BLAST539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei285PhosphoserineBy similarity1
Modified residuei303PhosphothreonineBy similarity1
Modified residuei305PhosphoserineBy similarity1
Modified residuei330PhosphoserineBy similarity1
Modified residuei407PhosphothreonineCombined sources1
Modified residuei473PhosphoserineBy similarity1
Modified residuei527PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9DCD5
MaxQBiQ9DCD5
PaxDbiQ9DCD5
PRIDEiQ9DCD5

PTM databases

iPTMnetiQ9DCD5
PhosphoSitePlusiQ9DCD5

Expressioni

Gene expression databases

BgeeiENSMUSG00000012296 Expressed in 253 organ(s), highest expression level in vestibular epithelium
CleanExiMM_TJAP1
ExpressionAtlasiQ9DCD5 baseline and differential
GenevisibleiQ9DCD5 MM

Interactioni

Subunit structurei

Interacts with DLG1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Arf6P623313EBI-775733,EBI-988682

Protein-protein interaction databases

BioGridi216487, 2 interactors
IntActiQ9DCD5, 4 interactors
MINTiQ9DCD5
STRINGi10090.ENSMUSP00000012440

Structurei

3D structure databases

ProteinModelPortaliQ9DCD5
SMRiQ9DCD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili32 – 165Sequence analysisAdd BLAST134

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJKM Eukaryota
ENOG410Z76C LUCA
GeneTreeiENSGT00530000063778
HOGENOMiHOG000154595
HOVERGENiHBG056279
InParanoidiQ9DCD5
KOiK06105
OMAiTHKMEAM
OrthoDBiEOG091G03KA
PhylomeDBiQ9DCD5
TreeFamiTF331612

Family and domain databases

InterProiView protein in InterPro
IPR028179 Tjap1
PANTHERiPTHR28664:SF3 PTHR28664:SF3, 1 hit
PfamiView protein in Pfam
PF15453 Pilt, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q9DCD5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSAAPAKKP YRKAPPEHRE LRLEIPVSRL EQEESLTDAE RMKLLQQENE
60 70 80 90 100
ELRKRLASAT RRTEALEREL EIGQDCLELE LGQSREELDK FKDKFRRLQN
110 120 130 140 150
SYTASQRTNQ ELEDKLHALI KKAEMDRKTL DWEIVELTNK LLDARNTINK
160 170 180 190 200
LEELNERYRL DCNLAVQLLK CNKSHFRNHK LADLPCELQD MVRKHLRSGQ
210 220 230 240 250
EVASPSPSPS SSLSPGAVVP TSVIARVLEK PESLLLNSAQ SGSAGRPLAE
260 270 280 290 300
DVFVHVDMSG GDPASPPAPG SPNGECCSVS TAGGSPEEEL PLPAFDKLSP
310 320 330 340 350
YPTPSPPHPL YPGRKVIEFS EDKIRIPRNS PLPNCTYATR QAISLSLVED
360 370 380 390 400
GSERAHRSSV PSSPASAQGS PHHQPSPAPS ALSAPASSAS SEEDLLASWQ
410 420 430 440 450
RAFVDRTPPP AAVVQRTAFG RDSLPELQLH FSPGHSTAPP PSPHRERGLV
460 470 480 490 500
LPAEPDSGFP QDEEEEMLNL PVSPEEERQS LLPDKEGTEE ASGPSHVDGR
510 520 530
AWPLPSPSRP QRSPKRMGVH HLHRKDSLTQ AQEQGTVLS
Length:539
Mass (Da):59,420
Last modified:June 1, 2001 - v1
Checksum:iFD169E54AD29E4DA
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I7H459I7H459_MOUSE
Protein incorporated later into tig...
Tjap1 Pilt
549Annotation score:
A0A286YDT8A0A286YDT8_MOUSE
Tight junction-associated protein 1
Tjap1
67Annotation score:
A0A286YCJ7A0A286YCJ7_MOUSE
Tight junction-associated protein 1
Tjap1
84Annotation score:
A0A286YDX8A0A286YDX8_MOUSE
Tight junction-associated protein 1
Tjap1
75Annotation score:
A0A286YE98A0A286YE98_MOUSE
Tight junction-associated protein 1
Tjap1
61Annotation score:
A0A286YD04A0A286YD04_MOUSE
Tight junction-associated protein 1
Tjap1
52Annotation score:
A0A286YDK3A0A286YDK3_MOUSE
Tight junction-associated protein 1
Tjap1
37Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti355A → S in AAH23316 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002882 mRNA Translation: BAB22429.1
AK169889 mRNA Translation: BAE41438.1
BC023316 mRNA Translation: AAH23316.1
AF465982 mRNA Translation: AAL76253.1
CCDSiCCDS28824.1
RefSeqiNP_001239402.1, NM_001252473.1
NP_001239403.1, NM_001252474.1
NP_001239404.1, NM_001252475.1
NP_083027.1, NM_028751.3
XP_011244979.1, XM_011246677.2
UniGeneiMm.284594
Mm.490004

Genome annotation databases

EnsembliENSMUST00000012440; ENSMUSP00000012440; ENSMUSG00000012296
ENSMUST00000164342; ENSMUSP00000130710; ENSMUSG00000012296
ENSMUST00000180283; ENSMUSP00000137220; ENSMUSG00000012296
ENSMUST00000225080; ENSMUSP00000153327; ENSMUSG00000012296
GeneIDi74094
KEGGimmu:74094
UCSCiuc008csf.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002882 mRNA Translation: BAB22429.1
AK169889 mRNA Translation: BAE41438.1
BC023316 mRNA Translation: AAH23316.1
AF465982 mRNA Translation: AAL76253.1
CCDSiCCDS28824.1
RefSeqiNP_001239402.1, NM_001252473.1
NP_001239403.1, NM_001252474.1
NP_001239404.1, NM_001252475.1
NP_083027.1, NM_028751.3
XP_011244979.1, XM_011246677.2
UniGeneiMm.284594
Mm.490004

3D structure databases

ProteinModelPortaliQ9DCD5
SMRiQ9DCD5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216487, 2 interactors
IntActiQ9DCD5, 4 interactors
MINTiQ9DCD5
STRINGi10090.ENSMUSP00000012440

PTM databases

iPTMnetiQ9DCD5
PhosphoSitePlusiQ9DCD5

Proteomic databases

EPDiQ9DCD5
MaxQBiQ9DCD5
PaxDbiQ9DCD5
PRIDEiQ9DCD5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000012440; ENSMUSP00000012440; ENSMUSG00000012296
ENSMUST00000164342; ENSMUSP00000130710; ENSMUSG00000012296
ENSMUST00000180283; ENSMUSP00000137220; ENSMUSG00000012296
ENSMUST00000225080; ENSMUSP00000153327; ENSMUSG00000012296
GeneIDi74094
KEGGimmu:74094
UCSCiuc008csf.2 mouse

Organism-specific databases

CTDi93643
MGIiMGI:1921344 Tjap1

Phylogenomic databases

eggNOGiENOG410IJKM Eukaryota
ENOG410Z76C LUCA
GeneTreeiENSGT00530000063778
HOGENOMiHOG000154595
HOVERGENiHBG056279
InParanoidiQ9DCD5
KOiK06105
OMAiTHKMEAM
OrthoDBiEOG091G03KA
PhylomeDBiQ9DCD5
TreeFamiTF331612

Miscellaneous databases

PROiPR:Q9DCD5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000012296 Expressed in 253 organ(s), highest expression level in vestibular epithelium
CleanExiMM_TJAP1
ExpressionAtlasiQ9DCD5 baseline and differential
GenevisibleiQ9DCD5 MM

Family and domain databases

InterProiView protein in InterPro
IPR028179 Tjap1
PANTHERiPTHR28664:SF3 PTHR28664:SF3, 1 hit
PfamiView protein in Pfam
PF15453 Pilt, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTJAP1_MOUSE
AccessioniPrimary (citable) accession number: Q9DCD5
Secondary accession number(s): Q8CFL7, Q8R5I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again