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Protein

UbiA prenyltransferase domain-containing protein 1

Gene

Ubiad1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays a important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress (By similarity).By similarity

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPrenyltransferase, Transferase
Biological processMenaquinone biosynthesis, Ubiquinone biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-6806664 Metabolism of vitamin K
UniPathwayi
UPA00079

UPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
UbiA prenyltransferase domain-containing protein 1 (EC:2.5.1.-)
Gene namesi
Name:Ubiad1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1918957 Ubiad1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Transmembranei243 – 265HelicalSequence analysisAdd BLAST23
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Transmembranei313 – 333HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002426282 – 336UbiA prenyltransferase domain-containing protein 1Add BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9DC60
PaxDbiQ9DC60
PRIDEiQ9DC60

PTM databases

iPTMnetiQ9DC60
PhosphoSitePlusiQ9DC60

Expressioni

Gene expression databases

BgeeiENSMUSG00000047719 Expressed in 230 organ(s), highest expression level in primary oocyte
CleanExiMM_UBIAD1
GenevisibleiQ9DC60 MM

Interactioni

Subunit structurei

Interacts with HMGCR and SOAT1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058502

Structurei

3D structure databases

ProteinModelPortaliQ9DC60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4581 Eukaryota
COG1575 LUCA
GeneTreeiENSGT00390000012439
HOGENOMiHOG000231452
HOVERGENiHBG080284
InParanoidiQ9DC60
KOiK00810
OMAiPPMYSVA
OrthoDBiEOG091G0C2Z
PhylomeDBiQ9DC60
TreeFamiTF323238

Family and domain databases

InterProiView protein in InterPro
IPR000537 UbiA_prenyltransferase
IPR026046 UBIAD1
PfamiView protein in Pfam
PF01040 UbiA, 1 hit
PIRSFiPIRSF005355 UBIAD1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DC60-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVQAPGEK INILAGETAK VGDPQKNEWP EQDRLPERSW RHKCASYVLA
60 70 80 90 100
LRPWSFSASL TPVALGSALA YRSQGVLDPR LLLGCAVAVL AVHGAGNLVN
110 120 130 140 150
TYYDFSKGID HKKSDDRTLV DRILEPQDVV RFGVFLYTLG CVCAACLYYL
160 170 180 190 200
SALKLEHLAL IYFGGLSGSF LYTGGIGFKY VALGDLVILI TFGPLAVMFA
210 220 230 240 250
YAVQVGSLAI FPLIYAIPLA LSTEAILHSN NTRDMESDRE AGIVTLAILI
260 270 280 290 300
GPTFSYVLYN TLLFVPYLIF TILATHCSIS LALPLLTIPM AFSLERQFRS
310 320 330
QAFNKLPQRT AKLNLLLGLF YVFGIILAPA GSLPRL
Length:336
Mass (Da):36,684
Last modified:June 1, 2001 - v1
Checksum:iCD0F2F8BE013FBF0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35L → F in CAQ51620 (PubMed:19468303).Curated1
Sequence conflicti35L → F in EDL14817 (Ref. 3) Curated1
Sequence conflicti35L → F in AAH71203 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004550 mRNA Translation: BAB23364.1
AK078442 mRNA Translation: BAC37276.2
AL731654 Genomic DNA Translation: CAM22523.1
CU210865 Genomic DNA Translation: CAQ51620.1
CH466594 Genomic DNA Translation: EDL14817.1
BC015303 mRNA Translation: AAH15303.1
BC071203 mRNA Translation: AAH71203.1
CCDSiCCDS18936.1
RefSeqiNP_082149.1, NM_027873.2
UniGeneiMm.292503

Genome annotation databases

EnsembliENSMUST00000051633; ENSMUSP00000058502; ENSMUSG00000047719
GeneIDi71707
KEGGimmu:71707
UCSCiuc008vup.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004550 mRNA Translation: BAB23364.1
AK078442 mRNA Translation: BAC37276.2
AL731654 Genomic DNA Translation: CAM22523.1
CU210865 Genomic DNA Translation: CAQ51620.1
CH466594 Genomic DNA Translation: EDL14817.1
BC015303 mRNA Translation: AAH15303.1
BC071203 mRNA Translation: AAH71203.1
CCDSiCCDS18936.1
RefSeqiNP_082149.1, NM_027873.2
UniGeneiMm.292503

3D structure databases

ProteinModelPortaliQ9DC60
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058502

PTM databases

iPTMnetiQ9DC60
PhosphoSitePlusiQ9DC60

Proteomic databases

MaxQBiQ9DC60
PaxDbiQ9DC60
PRIDEiQ9DC60

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051633; ENSMUSP00000058502; ENSMUSG00000047719
GeneIDi71707
KEGGimmu:71707
UCSCiuc008vup.1 mouse

Organism-specific databases

CTDi29914
MGIiMGI:1918957 Ubiad1

Phylogenomic databases

eggNOGiKOG4581 Eukaryota
COG1575 LUCA
GeneTreeiENSGT00390000012439
HOGENOMiHOG000231452
HOVERGENiHBG080284
InParanoidiQ9DC60
KOiK00810
OMAiPPMYSVA
OrthoDBiEOG091G0C2Z
PhylomeDBiQ9DC60
TreeFamiTF323238

Enzyme and pathway databases

UniPathwayi
UPA00079

UPA00232

ReactomeiR-MMU-6806664 Metabolism of vitamin K

Miscellaneous databases

ChiTaRSiUbiad1 mouse
PROiPR:Q9DC60
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047719 Expressed in 230 organ(s), highest expression level in primary oocyte
CleanExiMM_UBIAD1
GenevisibleiQ9DC60 MM

Family and domain databases

InterProiView protein in InterPro
IPR000537 UbiA_prenyltransferase
IPR026046 UBIAD1
PfamiView protein in Pfam
PF01040 UbiA, 1 hit
PIRSFiPIRSF005355 UBIAD1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBIA1_MOUSE
AccessioniPrimary (citable) accession number: Q9DC60
Secondary accession number(s): A2AH70
, B2KFZ5, Q6IR30, Q8BJX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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