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Protein

Copine-8

Gene

Cpne8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.By similarity

Caution

It is uncertain whether Met-1 or Met-14 is the initiator.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Copine-8Curated
Alternative name(s):
Copine VIIIImported
Gene namesi
Name:Cpne8Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1914121 Cpne8

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448501 – 577Copine-8Add BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9DC53
PaxDbiQ9DC53
PeptideAtlasiQ9DC53
PRIDEiQ9DC53

PTM databases

iPTMnetiQ9DC53
PhosphoSitePlusiQ9DC53

Expressioni

Gene expression databases

BgeeiENSMUSG00000052560 Expressed in 227 organ(s), highest expression level in lateral septal nucleus
CleanExiMM_CPNE8
ExpressionAtlasiQ9DC53 baseline and differential
GenevisibleiQ9DC53 MM

Interactioni

Protein-protein interaction databases

IntActiQ9DC53, 1 interactor
STRINGi10090.ENSMUSP00000067774

Structurei

3D structure databases

ProteinModelPortaliQ9DC53
SMRiQ9DC53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 130C2 1PROSITE-ProRule annotationAdd BLAST108
Domaini157 – 262C2 2PROSITE-ProRule annotationAdd BLAST106
Domaini322 – 523VWFAPROSITE-ProRule annotationAdd BLAST202

Sequence similaritiesi

Belongs to the copine family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1327 Eukaryota
ENOG410XPC8 LUCA
GeneTreeiENSGT00760000119085
HOGENOMiHOG000220898
HOVERGENiHBG066841
InParanoidiQ9DC53
OMAiFDAMIEL
OrthoDBiEOG091G05IT
PhylomeDBiQ9DC53
TreeFamiTF316419

Family and domain databases

CDDicd04047 C2B_Copine, 1 hit
cd01459 vWA_copine_like, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037768 C2B_Copine
IPR010734 Copine
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF07002 Copine, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50234 VWFA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9DC53-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWARDKCSVP QLEMDSRYTS ATGIGDLNQL SAAIPATRVE VSVSCRNLLD
60 70 80 90 100
RDTFSKSDPI CVLYTQAVGN KEWREFGRTE VIDNTLNPDF VRKFILDYFF
110 120 130 140 150
EERENLRFDL YDVDSKSPNL SKHDFLGQVF CTLGEIVGSQ GSRLEKPIVG
160 170 180 190 200
IPGRKCGTII LTAEELNCCR DAVLMQFCAN KLDKKDFFGK SDPFLVFYRS
210 220 230 240 250
NEDGSFTICH KTEVVKNTLN PVWQAFKISV RALCNGDYDR TIKVEVYDWD
260 270 280 290 300
RDGSHDFIGE FTTSYRELAR GQSQFNVYEV VNPKKKGKKK KYTNSGTVTL
310 320 330 340 350
LSFLVETEVS FLDYIKGGTQ INFTVAIDFT ASNGNPAQPT SLHYMNPYQL
360 370 380 390 400
NAYGMALKAV GEIVQDYDSD KMFPALGFGA KLPPDGRISH EFALNGNPQN
410 420 430 440 450
PYCDGIEGVM EAYYRSLKSV QLYGPTNFAP VINHVARYAS SVKDGSQYFV
460 470 480 490 500
LLIVTDGVIS DMAQTKESIV NASKLPMSII IVGVGPAEFD AMVELDGDDV
510 520 530 540 550
RVSSRGKYAE RDIVQFVPFR DYIDRSGNHI LSMARLAKDV LAEIPEQFLS
560 570
YMRARGIKPS PAPPPYTPPT HVLQTQI
Length:577
Mass (Da):64,667
Last modified:September 18, 2013 - v3
Checksum:i6287BF291AA0A0F4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9DB19Q9DB19_MOUSE
Copine VIII
Cpne8
104Annotation score:
Q9CYR4Q9CYR4_MOUSE
Copine-8
Cpne8
157Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004559 mRNA Translation: BAB23372.1
AK010227 mRNA Translation: BAB26781.1
AC099572 Genomic DNA No translation available.
AC113493 Genomic DNA No translation available.
AC116812 Genomic DNA No translation available.
CH466550 Genomic DNA Translation: EDL04322.1
BC138745 mRNA Translation: AAI38746.1
BC138746 mRNA Translation: AAI38747.1
CCDSiCCDS27758.1
RefSeqiNP_080091.1, NM_025815.2
UniGeneiMm.290991

Genome annotation databases

EnsembliENSMUST00000064391; ENSMUSP00000067774; ENSMUSG00000052560
GeneIDi66871
KEGGimmu:66871
UCSCiuc007xhn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004559 mRNA Translation: BAB23372.1
AK010227 mRNA Translation: BAB26781.1
AC099572 Genomic DNA No translation available.
AC113493 Genomic DNA No translation available.
AC116812 Genomic DNA No translation available.
CH466550 Genomic DNA Translation: EDL04322.1
BC138745 mRNA Translation: AAI38746.1
BC138746 mRNA Translation: AAI38747.1
CCDSiCCDS27758.1
RefSeqiNP_080091.1, NM_025815.2
UniGeneiMm.290991

3D structure databases

ProteinModelPortaliQ9DC53
SMRiQ9DC53
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DC53, 1 interactor
STRINGi10090.ENSMUSP00000067774

PTM databases

iPTMnetiQ9DC53
PhosphoSitePlusiQ9DC53

Proteomic databases

MaxQBiQ9DC53
PaxDbiQ9DC53
PeptideAtlasiQ9DC53
PRIDEiQ9DC53

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064391; ENSMUSP00000067774; ENSMUSG00000052560
GeneIDi66871
KEGGimmu:66871
UCSCiuc007xhn.1 mouse

Organism-specific databases

CTDi144402
MGIiMGI:1914121 Cpne8

Phylogenomic databases

eggNOGiKOG1327 Eukaryota
ENOG410XPC8 LUCA
GeneTreeiENSGT00760000119085
HOGENOMiHOG000220898
HOVERGENiHBG066841
InParanoidiQ9DC53
OMAiFDAMIEL
OrthoDBiEOG091G05IT
PhylomeDBiQ9DC53
TreeFamiTF316419

Miscellaneous databases

PROiPR:Q9DC53
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052560 Expressed in 227 organ(s), highest expression level in lateral septal nucleus
CleanExiMM_CPNE8
ExpressionAtlasiQ9DC53 baseline and differential
GenevisibleiQ9DC53 MM

Family and domain databases

CDDicd04047 C2B_Copine, 1 hit
cd01459 vWA_copine_like, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037768 C2B_Copine
IPR010734 Copine
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF07002 Copine, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCPNE8_MOUSE
AccessioniPrimary (citable) accession number: Q9DC53
Secondary accession number(s): B2RS65, Q9CUZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: September 18, 2013
Last modified: September 12, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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