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Protein

Pre-mRNA-processing factor 17

Gene

Cdc40

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing.By similarity

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72187 mRNA 3'-end processing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-processing factor 17
Alternative name(s):
Cell division cycle 40 homolog
PRP17 homolog
Gene namesi
Name:Cdc40
Synonyms:Prp17, Prpf17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1918963 Cdc40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511431 – 579Pre-mRNA-processing factor 17Add BLAST579

Proteomic databases

EPDiQ9DC48
MaxQBiQ9DC48
PaxDbiQ9DC48
PeptideAtlasiQ9DC48
PRIDEiQ9DC48

PTM databases

PhosphoSitePlusiQ9DC48

Expressioni

Gene expression databases

BgeeiENSMUSG00000038446 Expressed in 249 organ(s), highest expression level in ear
CleanExiMM_CDC40
GenevisibleiQ9DC48 MM

Interactioni

Subunit structurei

Identified in the spliceosome C complex.By similarity

Protein-protein interaction databases

BioGridi214875, 2 interactors
IntActiQ9DC48, 1 interactor
MINTiQ9DC48
STRINGi10090.ENSMUSP00000044305

Structurei

3D structure databases

ProteinModelPortaliQ9DC48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati286 – 326WD 1Add BLAST41
Repeati330 – 369WD 2Add BLAST40
Repeati371 – 413WD 3Add BLAST43
Repeati416 – 455WD 4Add BLAST40
Repeati459 – 498WD 5Add BLAST40
Repeati504 – 545WD 6Add BLAST42
Repeati548 – 578WD 7Add BLAST31

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0282 Eukaryota
ENOG410XP87 LUCA
GeneTreeiENSGT00530000063583
HOGENOMiHOG000214672
HOVERGENiHBG053695
InParanoidiQ9DC48
KOiK12816
OMAiSGGYVCF
OrthoDBiEOG091G03TK
PhylomeDBiQ9DC48
TreeFamiTF101064

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR032847 PRPF17
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR43979 PTHR43979, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DC48-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAAIAALAA SYGSGSGSES DSDSEGSRCP LPAADSLMHL TKSPSAKLSL
60 70 80 90 100
TVAVDSAPEV AVKEDLETGV HLDPAVKEVQ YNPTYETMFA PEFGPENPFR
110 120 130 140 150
TQQMAAPRNM LSGYAEPAHI NDFMFEQQRR TFATYGYALD PSLDNHQVSA
160 170 180 190 200
KYIGSVEEAE KNQGLTVFET GQKKTEKRKK FKENDASNID GFLGPWAKYV
210 220 230 240 250
DEKDVAKPSE EEQKELDEIT AKRQKKGKQE EEKPGEEKTI LHVKEMYDYQ
260 270 280 290 300
GRSYLHIPQD VGVNLRSSVP PEKCYLPKKQ IHVWSGHTKG VSAVRLFPLS
310 320 330 340 350
GHLLLSCSMD CKIKLWEVYG DRRCLRTFIG HSKAVRDICF NTAGTQFLSA
360 370 380 390 400
AYDRYLKLWD TETGQCISRF TNRKVPYCVK FNPDEDKQNL FVAGMSDKKI
410 420 430 440 450
VQWDIRSGEI VQEYDRHLGA VNTIVFVDEN RRFVSTSDDK SLRVWEWDIP
460 470 480 490 500
VDFKYIAEPS MHSMPAVTLS PNGKWLACQS MDNQILIFGA QNRFRLNKKK
510 520 530 540 550
IFKGHMVAGY ACQVDFSPDM SYVISGDGNG KLNIWDWKTT KLYSRFKAHD
560 570
KVCIGAVWHP HETSKVITCG WDGLIKLWD
Length:579
Mass (Da):65,461
Last modified:June 1, 2001 - v1
Checksum:i422A5FEB8D9CE2C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004569 mRNA Translation: BAB23380.1
BC147503 mRNA Translation: AAI47504.1
BC158078 mRNA Translation: AAI58079.1
CCDSiCCDS48546.1
RefSeqiNP_082155.1, NM_027879.2
UniGeneiMm.46063

Genome annotation databases

EnsembliENSMUST00000044166; ENSMUSP00000044305; ENSMUSG00000038446
GeneIDi71713
KEGGimmu:71713
UCSCiuc007exe.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004569 mRNA Translation: BAB23380.1
BC147503 mRNA Translation: AAI47504.1
BC158078 mRNA Translation: AAI58079.1
CCDSiCCDS48546.1
RefSeqiNP_082155.1, NM_027879.2
UniGeneiMm.46063

3D structure databases

ProteinModelPortaliQ9DC48
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214875, 2 interactors
IntActiQ9DC48, 1 interactor
MINTiQ9DC48
STRINGi10090.ENSMUSP00000044305

PTM databases

PhosphoSitePlusiQ9DC48

Proteomic databases

EPDiQ9DC48
MaxQBiQ9DC48
PaxDbiQ9DC48
PeptideAtlasiQ9DC48
PRIDEiQ9DC48

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044166; ENSMUSP00000044305; ENSMUSG00000038446
GeneIDi71713
KEGGimmu:71713
UCSCiuc007exe.3 mouse

Organism-specific databases

CTDi51362
MGIiMGI:1918963 Cdc40

Phylogenomic databases

eggNOGiKOG0282 Eukaryota
ENOG410XP87 LUCA
GeneTreeiENSGT00530000063583
HOGENOMiHOG000214672
HOVERGENiHBG053695
InParanoidiQ9DC48
KOiK12816
OMAiSGGYVCF
OrthoDBiEOG091G03TK
PhylomeDBiQ9DC48
TreeFamiTF101064

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72187 mRNA 3'-end processing

Miscellaneous databases

ChiTaRSiCdc40 mouse
PROiPR:Q9DC48
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038446 Expressed in 249 organ(s), highest expression level in ear
CleanExiMM_CDC40
GenevisibleiQ9DC48 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR032847 PRPF17
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR43979 PTHR43979, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRP17_MOUSE
AccessioniPrimary (citable) accession number: Q9DC48
Secondary accession number(s): B2RY33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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