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Entry version 115 (16 Oct 2019)
Sequence version 2 (05 Feb 2008)
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Protein

Telomere length regulation protein TEL2 homolog

Gene

Telo2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Telomere length regulation protein TEL2 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Telo2
Synonyms:Kiaa0683
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918968 Telo2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Chromosome, Cytoplasm, Membrane, Nucleus, Telomere

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi395L → Q: Does not inhibit interaction with TTI1 or TTI2. Inhibits weakly interaction with TTI1 or TTI2; when associated with E-407 or R-424. Inhibits interaction with TTI1 or TTI2; when associated with E-407 and R-424. 1 Publication1
Mutagenesisi407M → E: Does not inhibit interaction with TTI1 or TTI2. Inhibits weakly interaction with TTI1 or TTI2; when associated with Q-395 or R-424. Inhibits interaction with TTI1 or TTI2; when associated with Q-395 and R-424. 1 Publication1
Mutagenesisi424L → R: Does not inhibit interaction with TTI1 or TTI2. Inhibits weakly interaction with TTI1 or TTI2; when associated with Q-395 or E-407. Inhibits interaction with TTI1 or TTI2; when associated with Q-395 and E-407. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003185161 – 840Telomere length regulation protein TEL2 homologAdd BLAST840

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei374HydroxyprolineBy similarity1
Modified residuei419HydroxyprolineBy similarity1
Modified residuei422HydroxyprolineBy similarity1
Modified residuei457PhosphoserineCombined sources1
Modified residuei486Phosphoserine; by CK2By similarity1
Modified residuei488PhosphoserineBy similarity1
Modified residuei492PhosphoserineBy similarity1
Modified residuei837PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Hydroxylation by PHD3 is required for a proper interaction with ATR, and activation of the ATR/CHK1/p53 pathway following DNA damage.By similarity
Phosphorylated at Ser-486 by CK2 following growth factor deprivation, leading to its subsequent ubiquitination by the SCF(FBXO9) complex. Phosphorylation by CK2 only takes place when TELO2 is bound to mTORC1, not mTORC2; leading to selective ubiquitination of mTORC1-associated protein (By similarity).By similarity
Ubiquitinated by the SCF(FBXO9) complex following phosphorylation by CK2 in response to growth factor deprivation, leading to its degradation by the proteasome. Only mTORC1-associated protein is ubiquitinated and degraded, leading to selective inactivation of mTORC1 to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity).By similarity

Keywords - PTMi

Acetylation, Hydroxylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9DC40

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9DC40

PeptideAtlas

More...
PeptideAtlasi
Q9DC40

PRoteomics IDEntifications database

More...
PRIDEi
Q9DC40

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9DC40

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9DC40

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024170 Expressed in 263 organ(s), highest expression level in molar tooth

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9DC40 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the TTT complex composed of TELO2, TTI1 and TTI2.

Interacts with ATM, ATR, MTOR, PRKDC, RUVBL2, TTI1, TTI2, SMG1 and TRRAP.

Component of the mTORC1 and mTORC2 complexes.

Interacts (phosphorylated form) with PIH1D1 (PubMed:24794838). Interaction with PIH1D1 mediates interaction of TELO2 with the R2TP complex composed of RUVBL1, RUVBL2, PIH1D1, and RPAP3 (By similarity).

By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei491Interaction with PIH1D11 Publication1
Sitei492Interaction with PIH1D11 Publication1
Sitei493Interaction with PIH1D11 Publication1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9CQJ23EBI-1571482,EBI-11658528

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
214877, 5 interactors

Database of interacting proteins

More...
DIPi
DIP-60997N

Protein interaction database and analysis system

More...
IntActi
Q9DC40, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000110835

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1840
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9DC40

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TEL2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4346 Eukaryota
ENOG410XR2X LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006698

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9DC40

KEGG Orthology (KO)

More...
KOi
K11137

Identification of Orthologs from Complete Genome Data

More...
OMAi
SAVRHTP

Database of Orthologous Groups

More...
OrthoDBi
355610at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9DC40

TreeFam database of animal gene trees

More...
TreeFami
TF313925

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.720, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038528 TEL2_sf
IPR019337 Telomere_length_regulation_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10193 Telomere_reg-2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9DC40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPALSAVRL TVQEAIHILS SSEDAGHILS TLGTLKRYLG GTEDPVLPEE
60 70 80 90 100
KEEFATVHFS AVLRCLVSKL SPGWLELSPG GQLERLWESF FLDGPPDQAF
110 120 130 140 150
LVLMEAIEST AGPSFRLMKM AQLLDTFLST GRVAALMEEQ CRPQTKPSFP
160 170 180 190 200
LFQETLLSKV VGLPDLLGNC LQRDNLTQFF PQNYFPLLGQ EVVQALKAVV
210 220 230 240 250
NFLQDGLDCS VSFVSRVLGK VCIQGRKREI LSVLVPQLTV LTQDSCLWQR
260 270 280 290 300
VCWRLVEQVP DRAVEAVLTG LVEAAPRPEV LSRLLGNLVV KNKKARFVVT
310 320 330 340 350
RKLLLLQYQH TTPMVQSLLG YLALDSQRRP LLIQVLKELL ETWGCSSAVR
360 370 380 390 400
HTPLEQQCYI SKAILVCLAH LGEPELQDIR DELLASMMAG VKCRLDSSLP
410 420 430 440 450
PVRRLGMIVA EVISSRIHPE GPLLKFQYED DEMSRELLAL ATPEPAGDCS
460 470 480 490 500
SVSRGPSPAP VDTESPVEMP EKAVESDVPP TQPQGSDSEL DSDDEFIPYD
510 520 530 540 550
MSGDRELKSS KEPLYIRDCV EALTTSEDME RWEASLKGLE GLVYRSPTAT
560 570 580 590 600
REVSVELAKV LLHLEEKTCV AEFEQLRQSA LVAVTVTDPE QVAKYLTSQF
610 620 630 640 650
YGLNYSLRQR MDILDVLVLA AQALSRPKSL QRRSQHGPPV PGTMCSPALA
660 670 680 690 700
VSQTGNVAAP DWQVVVEERI RSKTRRFSKG CPQRELSGVP NEFSSVAGYF
710 720 730 740 750
FFPLLQHFDR PLVTFDLLGD DQLVLGRLTH TLASLMYLAV NTTVAVPMGK
760 770 780 790 800
ALLEFVWALR FHVDIYVRRG LLSAVSSVLL SVPTERLLGD LPDELLEARS
810 820 830 840
WLADVAEKDV DEDCRELAVR ALLLLERLKD KLLSSSSPQP
Length:840
Mass (Da):93,313
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC3ADB9DCE1724EAC
GO
Isoform 2 (identifier: Q9DC40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-386: Missing.
     680-690: GCPQRELSGVP → VTGLCSDPMLS
     691-840: Missing.

Note: No experimental confirmation available.
Show »
Length:304
Mass (Da):33,494
Checksum:i1C17E24740BEC671
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE25556 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18I → T in AAS21644 (Ref. 2) Curated1
Sequence conflicti18I → T in AAH11077 (PubMed:15489334).Curated1
Sequence conflicti106A → T in BAE32791 (PubMed:16141072).Curated1
Sequence conflicti205D → G in AAS21644 (Ref. 2) Curated1
Sequence conflicti205D → G in AAH11077 (PubMed:15489334).Curated1
Sequence conflicti461V → A in AAS21644 (Ref. 2) Curated1
Sequence conflicti461V → A in AAH11077 (PubMed:15489334).Curated1
Sequence conflicti465S → P in AAS21644 (Ref. 2) Curated1
Sequence conflicti465S → P in AAH11077 (PubMed:15489334).Curated1
Sequence conflicti509S → N in AAS21644 (Ref. 2) Curated1
Sequence conflicti509S → N in AAH11077 (PubMed:15489334).Curated1
Sequence conflicti548T → A in AAS21644 (Ref. 2) Curated1
Sequence conflicti548T → A in AAH11077 (PubMed:15489334).Curated1
Sequence conflicti638 – 639PP → SL in AAS21644 (Ref. 2) Curated2
Sequence conflicti638 – 639PP → SL in AAH11077 (PubMed:15489334).Curated2
Sequence conflicti664V → M in AAS21644 (Ref. 2) Curated1
Sequence conflicti664V → M in AAH11077 (PubMed:15489334).Curated1
Sequence conflicti689V → I in BAC26051 (PubMed:16141072).Curated1
Sequence conflicti775V → M in BAB23388 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0312071 – 386Missing in isoform 2. 1 PublicationAdd BLAST386
Alternative sequenceiVSP_031208680 – 690GCPQRELSGVP → VTGLCSDPMLS in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_031209691 – 840Missing in isoform 2. 1 PublicationAdd BLAST150

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK004582 mRNA Translation: BAB23388.1
AK045321 mRNA Translation: BAC32309.1
AK028658 mRNA Translation: BAC26051.1
AK143827 mRNA Translation: BAE25556.1 Sequence problems.
AK146963 mRNA Translation: BAE27569.1
AK154727 mRNA Translation: BAE32791.1
AY491413 Genomic DNA Translation: AAS21644.1
BC011077 mRNA Translation: AAH11077.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28507.1 [Q9DC40-1]

NCBI Reference Sequences

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RefSeqi
NP_001157133.1, NM_001163661.1 [Q9DC40-1]
NP_082156.2, NM_027880.2 [Q9DC40-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000024987; ENSMUSP00000024987; ENSMUSG00000024170 [Q9DC40-1]
ENSMUST00000115181; ENSMUSP00000110835; ENSMUSG00000024170 [Q9DC40-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
71718

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:71718

UCSC genome browser

More...
UCSCi
uc008azq.2 mouse [Q9DC40-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004582 mRNA Translation: BAB23388.1
AK045321 mRNA Translation: BAC32309.1
AK028658 mRNA Translation: BAC26051.1
AK143827 mRNA Translation: BAE25556.1 Sequence problems.
AK146963 mRNA Translation: BAE27569.1
AK154727 mRNA Translation: BAE32791.1
AY491413 Genomic DNA Translation: AAS21644.1
BC011077 mRNA Translation: AAH11077.1
CCDSiCCDS28507.1 [Q9DC40-1]
RefSeqiNP_001157133.1, NM_001163661.1 [Q9DC40-1]
NP_082156.2, NM_027880.2 [Q9DC40-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CKTX-ray3.00C/D489-496[»]
4CSEX-ray3.30C/D488-496[»]
SMRiQ9DC40
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi214877, 5 interactors
DIPiDIP-60997N
IntActiQ9DC40, 3 interactors
STRINGi10090.ENSMUSP00000110835

PTM databases

iPTMnetiQ9DC40
PhosphoSitePlusiQ9DC40

Proteomic databases

EPDiQ9DC40
PaxDbiQ9DC40
PeptideAtlasiQ9DC40
PRIDEiQ9DC40

Genome annotation databases

EnsembliENSMUST00000024987; ENSMUSP00000024987; ENSMUSG00000024170 [Q9DC40-1]
ENSMUST00000115181; ENSMUSP00000110835; ENSMUSG00000024170 [Q9DC40-1]
GeneIDi71718
KEGGimmu:71718
UCSCiuc008azq.2 mouse [Q9DC40-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9894
MGIiMGI:1918968 Telo2

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG4346 Eukaryota
ENOG410XR2X LUCA
GeneTreeiENSGT00390000006698
InParanoidiQ9DC40
KOiK11137
OMAiSAVRHTP
OrthoDBi355610at2759
PhylomeDBiQ9DC40
TreeFamiTF313925

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Telo2 mouse

Protein Ontology

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PROi
PR:Q9DC40

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000024170 Expressed in 263 organ(s), highest expression level in molar tooth
GenevisibleiQ9DC40 MM

Family and domain databases

Gene3Di1.25.40.720, 1 hit
InterProiView protein in InterPro
IPR038528 TEL2_sf
IPR019337 Telomere_length_regulation_dom
PfamiView protein in Pfam
PF10193 Telomere_reg-2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTELO2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9DC40
Secondary accession number(s): Q3U3J5
, Q3UID7, Q3UP41, Q8BN03, Q8C1T3, Q91VQ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: October 16, 2019
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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