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Protein

ATP-binding cassette sub-family B member 6, mitochondrial

Gene

Abcb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei599ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi623 – 634ATPPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1369007 Mitochondrial ABC transporters

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 6, mitochondrial
Gene namesi
Name:Abcb6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1921354 Abcb6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei73 – 93HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei107 – 127HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei148 – 168HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei186 – 206HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei264 – 284HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei292 – 312HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei376 – 396HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei409 – 431HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei500 – 520HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei530 – 550HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi170S → G: Results in retention of the protein in the Golgi apparatus. 1 Publication1
Mutagenesisi356L → P: Results in retention of the protein in the Golgi apparatus. 1 Publication1
Mutagenesisi579G → E: Results in retention of the protein in the Golgi apparatus. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686781 – 842ATP-binding cassette sub-family B member 6, mitochondrialAdd BLAST842

Proteomic databases

EPDiQ9DC29
MaxQBiQ9DC29
PaxDbiQ9DC29
PeptideAtlasiQ9DC29
PRIDEiQ9DC29

PTM databases

iPTMnetiQ9DC29
PhosphoSitePlusiQ9DC29

Expressioni

Developmental stagei

Highly expressed in embryonic liver.1 Publication

Inductioni

Up-regulated during erythroid differentiation and heme biosynthesis. Up-regulated by cellular porphyrins (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000026198
ExpressionAtlasiQ9DC29 baseline and differential
GenevisibleiQ9DC29 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027396

Structurei

3D structure databases

ProteinModelPortaliQ9DC29
SMRiQ9DC29
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini265 – 556ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST292
Domaini590 – 824ABC transporterPROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0057 Eukaryota
COG5265 LUCA
GeneTreeiENSGT00440000033373
HOVERGENiHBG080810
InParanoidiQ9DC29
KOiK05661
OMAiIVDRGTS
OrthoDBiEOG091G02G4
PhylomeDBiQ9DC29
TreeFamiTF105194

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR032410 MTABC_N
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
PF16185 MTABC_N, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DC29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTVGNYCET EGPAGPAWTQ NGLSPCFFFT LVPSTLLTLG VLALVLVLPR
60 70 80 90 100
RRREVPAGPE ELSWAAGPRV APYVLQLFLA TLQMALPLAG LAGRVGTARG
110 120 130 140 150
VRLPGYLLLA SVLESLASVC GLWLLVVERS QARQSLAMGV WMKFRHSLGL
160 170 180 190 200
LLLWTVTFAA ENLALVSWNS PQWWWARADL GQQVQFGLWV LRYVTSGGLF
210 220 230 240 250
ILGLWAPGLR PQSYTLHVHE EDQDVGGNQG RSTDRRSTWR DLGRKLRLLS
260 270 280 290 300
SYLWPRGSPS LQLIVLICLG LMGLERALNV LVPIFYRDIV NLLTAKAPWS
310 320 330 340 350
SLAWTVTTYV FLKFLQGGGT GSTGFVSNLR TFLWIRVQQF TSRGVELRLF
360 370 380 390 400
SHLHELSLRW HLGRRTGEVL RIVDRGTSSV TGLLSYLVFS IIPTLADIII
410 420 430 440 450
GIIYFSMFFN AWFGLIVFLC MSLYLILTIV VTEWRAKFRR DMNTQENATR
460 470 480 490 500
ARAVDSLLNF ETVKYYGAEG YEVDRYREAI LKFQGLEWKS TASLVVLNQT
510 520 530 540 550
QNLVIGLGLL AGSLLCAYFV SEQKLQVGDF VLFGTYITQL YMPLNWFGTY
560 570 580 590 600
YRMIQTNFID MENMFDLLKE ETEVKDVPGA GPLRFHKGRI EFENVHFSYA
610 620 630 640 650
DGQETLQDVS FTVMPGQTVA LVGPSGAGKS TILRLLFRFY DISSGCIRID
660 670 680 690 700
GQDISQVTQI SLRSHIGVVP QDTVLFNDTI ANNIRYGRVT AGDSEVEAAA
710 720 730 740 750
QAAGIHDAIL SFPEGYETQV GERGLKLSGG EKQRVAIART ILKAPDIILL
760 770 780 790 800
DEATSALDTS NERAIQASLA KVCTNRTTIV IAHRLSTVVN ADQILVIKDG
810 820 830 840
CIIERGRHEA LLSRGGVYAE MWQLQQQGQE TVPEESKPQD TA
Length:842
Mass (Da):93,770
Last modified:June 1, 2001 - v1
Checksum:i5B8E1653011A4C0D
GO

Sequence cautioni

The sequence BAE30168 differs from that shown. Reason: Frameshift at position 60.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004605 mRNA Translation: BAB23404.1
AK150853 mRNA Translation: BAE29909.1
AK151165 mRNA Translation: BAE30168.1 Frameshift.
AK152584 mRNA Translation: BAE31334.1
AK168642 mRNA Translation: BAE40501.1
BC006634 mRNA Translation: AAH06634.1
CCDSiCCDS15065.1
RefSeqiNP_076221.1, NM_023732.3
UniGeneiMm.28663

Genome annotation databases

EnsembliENSMUST00000027396; ENSMUSP00000027396; ENSMUSG00000026198
GeneIDi74104
KEGGimmu:74104
UCSCiuc007bnx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiABCB6_MOUSE
AccessioniPrimary (citable) accession number: Q9DC29
Secondary accession number(s): Q3U7N5, Q3UAZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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