Csnk1d

Functionⁱ

Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.9 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.1 Publication

ATP + [tau protein] = ADP + [tau protein] phosphate.1 Publication

Activity regulationⁱ

Exhibits substrate-dependent heparin activation. Drug-mediated inhibition leads to a delay of the oscillations with the magnitude of this effect dependent upon the timing of drug administration. Inhibited by phosphorylation (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	38	ATPPROSITE-ProRule annotation		1
Active siteⁱ	128	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	15 – 23	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
kinase activity Source: MGI
peptide binding Source: MGI
protein kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19414593
protein serine/threonine kinase activity Source: MGI
tau-protein kinase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to nerve growth factor stimulus Source: Ensembl
circadian regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19414593
- 21930935
Golgi organization Source: MGI
microtubule nucleation Source: MGI
non-motile cilium assembly
Source: MGI
Inferred from mutant phenotypeⁱ
- 24648492
peptidyl-serine phosphorylation Source: MGI
peptidyl-threonine phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of canonical Wnt signaling pathway Source: MGI
positive regulation of non-canonical Wnt signaling pathway
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 17244647
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19414593
positive regulation of protein phosphorylation Source: MGI
positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation
Source: ParkinsonsUK-UCL
Inferred by curatorⁱ
- 17244647
positive regulation of Wnt signaling pathway
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 17027228
protein localization to centrosome Source: MGI
protein localization to cilium Source: MGI
protein localization to Golgi apparatus Source: MGI
protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 19414593
regulation of circadian rhythm
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19414593
- 21930935
spindle assembly Source: MGI
Wnt signaling pathway Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Biological rhythms, Wnt signaling pathway
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-204005 COPII-mediated vesicle transport R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition R-MMU-380259 Loss of Nlp from mitotic centrosomes R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes R-MMU-380320 Recruitment of NuMA to mitotic centrosomes R-MMU-5620912 Anchoring of the basal body to the plasma membrane R-MMU-8854518 AURKA Activation by TPX2

Reactomeⁱ

R-MMU-204005 COPII-mediated vesicle transport
R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Casein kinase I isoform delta (EC:2.7.11.1) Short name: CKI-delta Short name: CKId Alternative name(s): Tau-protein kinase CSNK1D (EC:2.7.11.26)
Gene namesⁱ	Name:Csnk1d Synonyms:Hckid
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:1355272 Csnk1d

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Lethal. There are fewer embryos than expected at late stages of gestation; they weigh about 30% less than control animals, but appear otherwise normal. Mice die shortly after birth. Tissue-specific disruption increases the half-life of PER2 protein and alters circadian protein expression dynamics.2 Publications

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	44	T → A: Increases pain sensitivity; reduces threshold for induction of cortical spreading depression; increases arterial dilation during cortical spreading depression and increases spontaneous and evoked calcium signaling in astrocytes. 1 Publication		1

Chemistry databases

ChEMBLⁱ	CHEMBL5175

ChEMBLⁱ

CHEMBL5175

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000192834	1 – 415	Casein kinase I isoform deltaAdd BLAST		415

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	328	PhosphoserineBy similarity	1
Modified residueⁱ	331	PhosphoserineBy similarity	1
Modified residueⁱ	370	PhosphoserineBy similarity	1
Modified residueⁱ	375	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	382	PhosphoserineCombined sources	1
Modified residueⁱ	383	PhosphoserineCombined sources	1
Modified residueⁱ	384	PhosphoserineBy similarity	1
Modified residueⁱ	407	PhosphoserineBy similarity	1
Modified residueⁱ	411	PhosphoserineBy similarity	1
Isoform 2 (identifier: Q9DC28-2)
Modified residueⁱ	401	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated by phosphatase-mediated dephosphorylation. May be dephosphorylated by PP1.

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9DC28
PeptideAtlas More...PeptideAtlasⁱ	Q9DC28
PRIDEⁱ	Q9DC28

PTM databases

iPTMnetⁱ	Q9DC28
PhosphoSitePlusⁱ	Q9DC28
SwissPalmⁱ	Q9DC28

Expressionⁱ

Tissue specificityⁱ

Expressed ubiquitously. However, kinase activity is not uniform, with highest kinase activity in splenocytes.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000025162 Expressed in 309 organ(s), highest expression level in paneth cell
CleanExⁱ	MM_CSNK1D
ExpressionAtlasⁱ	Q9DC28 baseline and differential
Genevisibleⁱ	Q9DC28 MM

Interactionⁱ

Subunit structureⁱ

Binds to MAP1A. Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts with MAPT/TAU, DBNDD2, AIB1/NCOA3 and ESR1. AKAP9/AKAP450 binding promotes centrosomal subcellular location. Binds to tubulins in mitotic cells upon DNA damage. Binds to SNAPIN and DNMT1.2 Publications

Protein-protein interaction databases

BioGridⁱ	222545, 22 interactors
Database of interacting proteins More...DIPⁱ	DIP-47809N
IntActⁱ	Q9DC28, 20 interactors
Molecular INTeraction database More...MINTⁱ	Q9DC28
STRINGⁱ	10090.ENSMUSP00000018274

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	6 – 8	Combined sources	3
Beta strandⁱ	9 – 16	Combined sources	8
Beta strandⁱ	19 – 28	Combined sources	10
Turnⁱ	29 – 32	Combined sources	4
Beta strandⁱ	33 – 41	Combined sources	9
Helixⁱ	49 – 58	Combined sources	10
Turnⁱ	59 – 61	Combined sources	3
Beta strandⁱ	68 – 74	Combined sources	7
Beta strandⁱ	77 – 83	Combined sources	7
Helixⁱ	89 – 95	Combined sources	7
Turnⁱ	96 – 98	Combined sources	3
Helixⁱ	102 – 121	Combined sources	20
Helixⁱ	131 – 133	Combined sources	3
Beta strandⁱ	134 – 136	Combined sources	3
Helixⁱ	139 – 141	Combined sources	3
Beta strandⁱ	145 – 147	Combined sources	3
Turnⁱ	159 – 161	Combined sources	3
Helixⁱ	177 – 179	Combined sources	3
Helixⁱ	182 – 185	Combined sources	4
Helixⁱ	192 – 208	Combined sources	17
Turnⁱ	212 – 215	Combined sources	4
Helixⁱ	221 – 233	Combined sources	13
Helixⁱ	237 – 240	Combined sources	4
Turnⁱ	241 – 243	Combined sources	3
Helixⁱ	247 – 257	Combined sources	11
Helixⁱ	266 – 279	Combined sources	14
Helixⁱ	289 – 291	Combined sources	3
Beta strandⁱ	295 – 297	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9DC28
SMRⁱ	Q9DC28
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	9 – 277	Protein kinasePROSITE-ProRule annotationAdd BLAST		269

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	278 – 364	Centrosomal localization signal (CLS)By similarityAdd BLAST		87
Regionⁱ	317 – 342	AutoinhibitoryBy similarityAdd BLAST		26

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG1164 Eukaryota ENOG410XPGP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150814
HOGENOMⁱ	HOG000182055
HOVERGENⁱ	HBG000176
InParanoidⁱ	Q9DC28
KEGG Orthology (KO) More...KOⁱ	K08959
OMAⁱ	RWYGTEC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AFG
TreeFamⁱ	TF300544

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9DC28-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH 
        60         70         80         90        100
IESKIYKMMQ GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF 
       110        120        130        140        150
SLKTVLLLAD QMISRIEYIH SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF 
       160        170        180        190        200
GLAKKYRDAR THQHIPYREN KNLTGTARYA SINTHLGIEQ SRRDDLESLG 
       210        220        230        240        250
YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL CKGYPSEFAT 
       260        270        280        290        300
YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA 
       310        320        330        340        350
ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS 
       360        370        380        390        400
HTANTSPRPV SGMERERKVS MRLHRGAPVN VSSSDLTGRQ DTSRMSTSQI 
       410 
PGRVASSGLQ SVVHR

Length:415

Mass (Da):47,316

Last modified:May 10, 2004 - v2

Checksum:ⁱB97F04AF9EB466D2

GO

Isoform 2 (identifier: Q9DC28-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
400-415: IPGRVASSGLQSVVHR → NSIPFEHHGK

« Hide

        10         20         30         40         50
MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH 
        60         70         80         90        100
IESKIYKMMQ GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF 
       110        120        130        140        150
SLKTVLLLAD QMISRIEYIH SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF 
       160        170        180        190        200
GLAKKYRDAR THQHIPYREN KNLTGTARYA SINTHLGIEQ SRRDDLESLG 
       210        220        230        240        250
YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL CKGYPSEFAT 
       260        270        280        290        300
YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA 
       310        320        330        340        350
ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS 
       360        370        380        390        400
HTANTSPRPV SGMERERKVS MRLHRGAPVN VSSSDLTGRQ DTSRMSTSQN 

SIPFEHHGK

Show »

Length:409

Mass (Da):46,818

Checksum:ⁱ970B55B1B19AB9DD

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F7A4U8	F7A4U8_MOUSE	Casein kinase I isoform delta Casein kinase I isoform delta	Csnk1d	218	Annotation score:
F6VU53	F6VU53_MOUSE	Casein kinase I isoform delta Casein kinase I isoform delta	Csnk1d	68	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	313	E → G in BAB23405 (PubMed:16141072).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_010254	400 – 415	IPGRV…SVVHR → NSIPFEHHGK in isoform 2. 1 PublicationAdd BLAST		16

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK004606 mRNA Translation: BAB23405.1 AK088642 mRNA Translation: BAC40472.1 AK152721 mRNA Translation: BAE31444.1 AK157812 mRNA Translation: BAE34206.1 BC004604 mRNA Translation: AAH04604.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25762.1 [Q9DC28-1] CCDS25763.1 [Q9DC28-2]
PIRⁱ	S47616
NCBI Reference Sequences More...RefSeqⁱ	NP_620690.1, NM_139059.2 [Q9DC28-1]
UniGeneⁱ	Mm.216227

Genome annotation databases

Ensemblⁱ	ENSMUST00000018274; ENSMUSP00000018274; ENSMUSG00000025162 [Q9DC28-1] ENSMUST00000070575; ENSMUSP00000070721; ENSMUSG00000025162 [Q9DC28-2]
GeneIDⁱ	104318
KEGGⁱ	mmu:104318
UCSC genome browser More...UCSCⁱ	uc007mvb.1 mouse [Q9DC28-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9DC28	Casein kinase I isoform delta	)	RAT		415	UniRef100_Q9DC28
Uncharacterized protein		CAVPO		415
Casein kinase I		CASCN		415
Uncharacterized protein		NEOLE		415
Q9DC28-2	Casein kinase 1, delta, isoform CRA_c		MOUSE		409	UniRef100_Q3UBT6
Casein kinase 1 delta		MESAU		409
Uncharacterized protein		CAVPO		409
Uncharacterized protein		ICTTR		383
casein kinase I isoform delta isoform X2		DIPOR		352

Protein	Similar proteins		Species	Score	Length	Source
Q9DC28	Casein kinase I isoform delta	)	HUMAN		415	UniRef90_P48730
Casein kinase I isoform delta		BOVIN		415
Casein kinase I isoform delta		XENTR		415
Casein kinase I isoform delta		XENLA		415
Casein kinase I isoform delta		PONAB		415
+120
Q9DC28-2	Uncharacterized protein		CHICK		409	UniRef90_E1BVW0
casein kinase I-like		Asian bonytongue		415
Uncharacterized protein		ORNAN		414
casein kinase I isoform delta-B isoform X4		SALSA		414
Casein kinase I isoform 2		SCOMX		414
+233

Protein	Similar proteins		Species	Score	Length	Source
Q9DC28	Casein kinase I isoform delta	)	HUMAN		415	UniRef50_P48730
Casein kinase I isoform delta		BOVIN		415
Casein kinase I isoform delta		PONAB		415
Casein kinase I isoform delta		XENLA		415
Casein kinase I isoform delta	)	RAT		415
+163
Q9DC28-2	Casein kinase I isoform epsilon	)	HUMAN		416	UniRef50_P49674
Casein kinase I isoform epsilon		CHICK		416
Casein kinase I isoform epsilon		MOUSE		416
Casein kinase I isoform delta-B		DANRE		409
CSNK1E isoform 1		PANTR		416
+577

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK004606 mRNA Translation: BAB23405.1 AK088642 mRNA Translation: BAC40472.1 AK152721 mRNA Translation: BAE31444.1 AK157812 mRNA Translation: BAE34206.1 BC004604 mRNA Translation: AAH04604.1
CCDSⁱ	CCDS25762.1 [Q9DC28-1] CCDS25763.1 [Q9DC28-2]
PIRⁱ	S47616
RefSeqⁱ	NP_620690.1, NM_139059.2 [Q9DC28-1]
UniGeneⁱ	Mm.216227

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4JJR	X-ray	2.41	A/B	1-299	[»]
	5X17	X-ray	2.00	A/B	1-294	[»]
ProteinModelPortalⁱ	Q9DC28
SMRⁱ	Q9DC28
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	222545, 22 interactors
DIPⁱ	DIP-47809N
IntActⁱ	Q9DC28, 20 interactors
MINTⁱ	Q9DC28
STRINGⁱ	10090.ENSMUSP00000018274

Chemistry databases

ChEMBLⁱ	CHEMBL5175

ChEMBLⁱ

CHEMBL5175

PTM databases

iPTMnetⁱ	Q9DC28
PhosphoSitePlusⁱ	Q9DC28
SwissPalmⁱ	Q9DC28

Proteomic databases

PaxDbⁱ	Q9DC28
PeptideAtlasⁱ	Q9DC28
PRIDEⁱ	Q9DC28

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000018274; ENSMUSP00000018274; ENSMUSG00000025162 [Q9DC28-1] ENSMUST00000070575; ENSMUSP00000070721; ENSMUSG00000025162 [Q9DC28-2]
GeneIDⁱ	104318
KEGGⁱ	mmu:104318
UCSCⁱ	uc007mvb.1 mouse [Q9DC28-1]

Organism-specific databases

CTDⁱ	1453
MGIⁱ	MGI:1355272 Csnk1d

Phylogenomic databases

eggNOGⁱ	KOG1164 Eukaryota ENOG410XPGP LUCA
GeneTreeⁱ	ENSGT00930000150814
HOGENOMⁱ	HOG000182055
HOVERGENⁱ	HBG000176
InParanoidⁱ	Q9DC28
KOⁱ	K08959
OMAⁱ	RWYGTEC
OrthoDBⁱ	EOG091G0AFG
TreeFamⁱ	TF300544

Enzyme and pathway databases

Reactomeⁱ	R-MMU-204005 COPII-mediated vesicle transport R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition R-MMU-380259 Loss of Nlp from mitotic centrosomes R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes R-MMU-380320 Recruitment of NuMA to mitotic centrosomes R-MMU-5620912 Anchoring of the basal body to the plasma membrane R-MMU-8854518 AURKA Activation by TPX2

Reactomeⁱ

R-MMU-204005 COPII-mediated vesicle transport
R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRSⁱ	Csnk1d mouse
Protein Ontology More...PROⁱ	PR:Q9DC28
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000025162 Expressed in 309 organ(s), highest expression level in paneth cell
CleanExⁱ	MM_CSNK1D
ExpressionAtlasⁱ	Q9DC28 baseline and differential
Genevisibleⁱ	Q9DC28 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KC1D_MOUSE
Accessionⁱ	Q9DC28Primary (citable) accession number: Q9DC28 Secondary accession number(s): Q3TZK2, Q99KK4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
	Last sequence update:	May 10, 2004
	Last modified:	November 7, 2018
	This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q9DC28 (KC1D_MOUSE)

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Casein kinase I isoform delta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Plasma membrane

Cytoskeleton

Nucleus

Other locations

Cytoskeleton

Cytosol

Golgi apparatus

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ