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Protein

Solute carrier family 46 member 3

Gene

Slc46a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 46 member 3
Gene namesi
Name:Slc46a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1918956 Slc46a3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 73ExtracellularSequence analysisAdd BLAST48
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 111CytoplasmicSequence analysisAdd BLAST17
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 135ExtracellularSequence analysis3
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 170CytoplasmicSequence analysisAdd BLAST14
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 195ExtracellularSequence analysis4
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 257CytoplasmicSequence analysisAdd BLAST41
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 301ExtracellularSequence analysisAdd BLAST23
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Topological domaini323 – 324CytoplasmicSequence analysis2
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Topological domaini346 – 347ExtracellularSequence analysis2
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 381CytoplasmicSequence analysisAdd BLAST13
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Topological domaini403 – 410ExtracellularSequence analysis8
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Topological domaini432 – 460CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000030725426 – 460Solute carrier family 46 member 3Add BLAST435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9DC26
PRIDEiQ9DC26

PTM databases

PhosphoSitePlusiQ9DC26

Expressioni

Gene expression databases

BgeeiENSMUSG00000029650 Expressed in 178 organ(s), highest expression level in epithelium of small intestine
CleanExiMM_SLC46A3
ExpressionAtlasiQ9DC26 baseline and differential
GenevisibleiQ9DC26 MM

Interactioni

Protein-protein interaction databases

IntActiQ9DC26, 1 interactor
STRINGi10090.ENSMUSP00000031655

Structurei

3D structure databases

ProteinModelPortaliQ9DC26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2816 Eukaryota
ENOG410ZVCA LUCA
GeneTreeiENSGT00530000063076
HOGENOMiHOG000074207
HOVERGENiHBG108453
InParanoidiQ9DC26
KOiK20840
OMAiEVYIGYG
OrthoDBiEOG091G08MP
PhylomeDBiQ9DC26
TreeFamiTF315701

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9DC26-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKISFIEPAI LLNAFAMTLT IPLTAQYVYR RIWEETGNYT FASNSNGSEC
60 70 80 90 100
DQNKSSSIFA FREEVQKKAS LFNLQVEMSA LIPGLVSTFM LLASSDNHGR
110 120 130 140 150
KLPMVLSSLG SLGTNTWLCM MSYFDLPLQL LIASTFIGAL FGNYTTFWGA
160 170 180 190 200
CFAYIVDQQK EYKHRIIRIA ILDFMLGVVT GLTGLSSGYF IRELGFVWSY
210 220 230 240 250
FITAMVLIVN LAYILFFLND PIKESSSQIV TMSCIESLKD LFYRTYMLFK
260 270 280 290 300
NGSSKRQALL CLLIFTLVIY FFVIIGISPI FTLYELGPPL CWNEVYIGYG
310 320 330 340 350
SALGSVSFLS SFLGIWLFSY CLKDIHIAYI GIFTTMVGMT LAAFTRTTLM
360 370 380 390 400
MFLVRIPFIF TIMPLSVLRS MLSKVVHSTE QGALFACIAF LETLAGVTST
410 420 430 440 450
SAYSGIYSAT VAWYPGFIFL LSAGLLVLPA ISLCCVKSIG WEEGSYTLLV
460
HEEPSEHTSD
Length:460
Mass (Da):51,383
Last modified:June 1, 2001 - v1
Checksum:i819C90106C020793
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YWM2D3YWM2_MOUSE
Solute carrier family 46 member 3
Slc46a3
47Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004609 mRNA Translation: BAB23407.1
AK156898 mRNA Translation: BAE33889.1
BC006902 mRNA Translation: AAH06902.1
CCDSiCCDS19880.1
RefSeqiNP_082148.1, NM_027872.3
XP_006504928.1, XM_006504865.3
XP_006504929.1, XM_006504866.3
XP_006504930.1, XM_006504867.3
UniGeneiMm.153218

Genome annotation databases

EnsembliENSMUST00000031655; ENSMUSP00000031655; ENSMUSG00000029650
ENSMUST00000118527; ENSMUSP00000113879; ENSMUSG00000029650
GeneIDi71706
KEGGimmu:71706
UCSCiuc009aol.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004609 mRNA Translation: BAB23407.1
AK156898 mRNA Translation: BAE33889.1
BC006902 mRNA Translation: AAH06902.1
CCDSiCCDS19880.1
RefSeqiNP_082148.1, NM_027872.3
XP_006504928.1, XM_006504865.3
XP_006504929.1, XM_006504866.3
XP_006504930.1, XM_006504867.3
UniGeneiMm.153218

3D structure databases

ProteinModelPortaliQ9DC26
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DC26, 1 interactor
STRINGi10090.ENSMUSP00000031655

PTM databases

PhosphoSitePlusiQ9DC26

Proteomic databases

PaxDbiQ9DC26
PRIDEiQ9DC26

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031655; ENSMUSP00000031655; ENSMUSG00000029650
ENSMUST00000118527; ENSMUSP00000113879; ENSMUSG00000029650
GeneIDi71706
KEGGimmu:71706
UCSCiuc009aol.1 mouse

Organism-specific databases

CTDi283537
MGIiMGI:1918956 Slc46a3

Phylogenomic databases

eggNOGiKOG2816 Eukaryota
ENOG410ZVCA LUCA
GeneTreeiENSGT00530000063076
HOGENOMiHOG000074207
HOVERGENiHBG108453
InParanoidiQ9DC26
KOiK20840
OMAiEVYIGYG
OrthoDBiEOG091G08MP
PhylomeDBiQ9DC26
TreeFamiTF315701

Miscellaneous databases

PROiPR:Q9DC26
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029650 Expressed in 178 organ(s), highest expression level in epithelium of small intestine
CleanExiMM_SLC46A3
ExpressionAtlasiQ9DC26 baseline and differential
GenevisibleiQ9DC26 MM

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS46A3_MOUSE
AccessioniPrimary (citable) accession number: Q9DC26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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