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Protein

Endoplasmic reticulum-Golgi intermediate compartment protein 1

Gene

Ergic1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible role in transport between endoplasmic reticulum and Golgi.By similarity

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum-Golgi intermediate compartment protein 1
Alternative name(s):
ER-Golgi intermediate compartment 32 kDa protein
Short name:
ERGIC-32
Gene namesi
Name:Ergic1
Synonyms:Ergic32
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914708 Ergic1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Topological domaini48 – 254LumenalSequence analysisAdd BLAST207
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 290CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000870241 – 290Endoplasmic reticulum-Golgi intermediate compartment protein 1Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...) asparagineBy similarity1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9DC16
MaxQBiQ9DC16
PaxDbiQ9DC16
PRIDEiQ9DC16
TopDownProteomicsiQ9DC16

PTM databases

iPTMnetiQ9DC16
PhosphoSitePlusiQ9DC16
SwissPalmiQ9DC16

Expressioni

Gene expression databases

BgeeiENSMUSG00000001576
ExpressionAtlasiQ9DC16 baseline and differential
GenevisibleiQ9DC16 MM

Interactioni

Subunit structurei

Interacts with ERGIC3/ERV46.By similarity

Protein-protein interaction databases

BioGridi212202, 1 interactor
IntActiQ9DC16, 3 interactors
MINTiQ9DC16
STRINGi10090.ENSMUSP00000132922

Structurei

3D structure databases

ProteinModelPortaliQ9DC16
SMRiQ9DC16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERGIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2667 Eukaryota
ENOG410XP7X LUCA
GeneTreeiENSGT00530000063113
HOVERGENiHBG081479
InParanoidiQ9DC16
KOiK20365
OMAiFSYQYTV
OrthoDBiEOG091G0DGE
TreeFamiTF354253

Family and domain databases

InterProiView protein in InterPro
IPR012936 Erv_C
PfamiView protein in Pfam
PF07970 COPIIcoated_ERV, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DC16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFDFRRFDI YRKVPKDLTQ PTYTGAIISI CCCLFILFLF LSELTGFITT
60 70 80 90 100
EVVNELYVDD PDKDSGGKID VSLNISLPNL HCELVGLDIQ DEMGRHEVGH
110 120 130 140 150
IDNSMKIPLN NGAGCRFEGQ FSINKVPGNF HVSTHSATAQ PQNPDMTHTI
160 170 180 190 200
HKLSFGDTLQ VQNVHGAFNA LGGADRLTSN PLASHDYILK IVPTVYEDKS
210 220 230 240 250
GKQRYSYQYT VANKEYVAYS HTGRIIPAIW FRYDLSPITV KYTERRQPLY
260 270 280 290
RFITTICAII GGTFTVAGIL DSCIFTASEA WKKIQLGKIH
Length:290
Mass (Da):32,562
Last modified:June 1, 2001 - v1
Checksum:i9F6507BB1D89D46F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004629 mRNA Translation: BAB23423.1
AK084385 mRNA Translation: BAC39170.1
AK088157 mRNA Translation: BAC40179.1
BC005516 mRNA Translation: AAH05516.1
BC083144 mRNA Translation: AAH83144.1
CCDSiCCDS28553.1
RefSeqiNP_080446.1, NM_026170.3
UniGeneiMm.30496

Genome annotation databases

EnsembliENSMUST00000167662; ENSMUSP00000132922; ENSMUSG00000001576
GeneIDi67458
KEGGimmu:67458
UCSCiuc008bef.1 mouse

Similar proteinsi

Entry informationi

Entry nameiERGI1_MOUSE
AccessioniPrimary (citable) accession number: Q9DC16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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