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Protein

Plexin domain-containing protein 2

Gene

Plxdc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in tumor angiogenesis.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin domain-containing protein 2
Alternative name(s):
Tumor endothelial marker 7-related protein
Gene namesi
Name:Plxdc2
Synonyms:Tem7r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914698 Plxdc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 455ExtracellularSequence analysisAdd BLAST425
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Topological domaini477 – 530CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000023457531 – 530Plexin domain-containing protein 2Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei507PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9DC11
PaxDbiQ9DC11
PeptideAtlasiQ9DC11
PRIDEiQ9DC11

PTM databases

iPTMnetiQ9DC11
PhosphoSitePlusiQ9DC11

Expressioni

Tissue specificityi

Expressed in tumor endothelium and in vessels of some normal tissues, such as the muscle and lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000026748 Expressed in 275 organ(s), highest expression level in vestibular membrane of cochlear duct
CleanExiMM_PLXDC2
ExpressionAtlasiQ9DC11 baseline and differential
GenevisibleiQ9DC11 MM

Interactioni

Subunit structurei

Interacts with CTTN.1 Publication

Protein-protein interaction databases

IntActiQ9DC11, 1 interactor
MINTiQ9DC11
STRINGi10090.ENSMUSP00000028081

Structurei

3D structure databases

ProteinModelPortaliQ9DC11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini327 – 372PSIAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi385 – 428Thr-richAdd BLAST44

Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3848 Eukaryota
ENOG410Y7ZQ LUCA
GeneTreeiENSGT00440000033408
HOGENOMiHOG000234044
HOVERGENiHBG079500
InParanoidiQ9DC11
OMAiRVIYEYH
OrthoDBiEOG091G0827
PhylomeDBiQ9DC11
TreeFamiTF314400

Family and domain databases

InterProiView protein in InterPro
IPR002165 Plexin_repeat
IPR031152 PLXDC
IPR031154 PLXDC2
IPR016201 PSI
PANTHERiPTHR13055 PTHR13055, 1 hit
PTHR13055:SF11 PTHR13055:SF11, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
SMARTiView protein in SMART
SM00423 PSI, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9DC11-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARFRRADLA AAGVMLLCHF LTDRFQFAHG EPGHHTNDWI YEVTNAFPWN
60 70 80 90 100
EEGVEVDSQA YNHRWKRNVD PFKAVDTNRA SMGQASPESK GFTDLLLDDG
110 120 130 140 150
QDNNTQIEED TDHNYYISRI YGPADSASRD LWVNIDQMEK DKVKIHGILS
160 170 180 190 200
NTHRQAARVN LSFDFPFYGH FLNEVTVATG GFIYTGEVVH RMLTATQYIA
210 220 230 240 250
PLMANFDPSV SRNSTVRYFD NGTALVVQWD HVHLQDNYNL GSFTFQATLL
260 270 280 290 300
MDGRIIFGYK EIPVLVTQIS STNHPVKVGL SDAFVVVHRI QQIPNVRRRT
310 320 330 340 350
IYEYHRVELQ MSKITNISAV EMTPLPTCLQ FNGCGPCVSS QIGFNCSWCS
360 370 380 390 400
KLQRCSSGFD RHRQDWVDSG CPEEVQSKEK MCEKTEPGET SQTTTTSHTT
410 420 430 440 450
TMQFRVLTTT RRAVTSQMPT SLPTEDDTKI ALHLKDSGAS TDDSAAEKKG
460 470 480 490 500
GTLHAGLIVG ILILVLIIAA AILVTVYMYH HPTSAASIFF IERRPSRWPA
510 520 530
MKFRRGSGHP AYAEVEPVGE KEGFIVSEQC
Length:530
Mass (Da):59,616
Last modified:June 1, 2001 - v1
Checksum:iFB956C020735E36D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AY85B1AY85_MOUSE
Plexin domain-containing protein 2
Plxdc2
528Annotation score:
B1AY86B1AY86_MOUSE
Plexin domain-containing protein 2
Plxdc2
479Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5R → W in AAH57881 (PubMed:15489334).Curated1
Sequence conflicti26Q → H in AAL11998 (PubMed:11559528).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378761 mRNA Translation: AAL11998.1
AK004640 mRNA Translation: BAB23431.1
AK154921 mRNA Translation: BAE32927.1
BC057881 mRNA Translation: AAH57881.1
CCDSiCCDS15705.1
RefSeqiNP_080438.2, NM_026162.6
UniGeneiMm.313938
Mm.394655
Mm.437344

Genome annotation databases

EnsembliENSMUST00000028081; ENSMUSP00000028081; ENSMUSG00000026748
GeneIDi67448
KEGGimmu:67448
UCSCiuc008ikz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378761 mRNA Translation: AAL11998.1
AK004640 mRNA Translation: BAB23431.1
AK154921 mRNA Translation: BAE32927.1
BC057881 mRNA Translation: AAH57881.1
CCDSiCCDS15705.1
RefSeqiNP_080438.2, NM_026162.6
UniGeneiMm.313938
Mm.394655
Mm.437344

3D structure databases

ProteinModelPortaliQ9DC11
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DC11, 1 interactor
MINTiQ9DC11
STRINGi10090.ENSMUSP00000028081

PTM databases

iPTMnetiQ9DC11
PhosphoSitePlusiQ9DC11

Proteomic databases

MaxQBiQ9DC11
PaxDbiQ9DC11
PeptideAtlasiQ9DC11
PRIDEiQ9DC11

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028081; ENSMUSP00000028081; ENSMUSG00000026748
GeneIDi67448
KEGGimmu:67448
UCSCiuc008ikz.2 mouse

Organism-specific databases

CTDi84898
MGIiMGI:1914698 Plxdc2

Phylogenomic databases

eggNOGiKOG3848 Eukaryota
ENOG410Y7ZQ LUCA
GeneTreeiENSGT00440000033408
HOGENOMiHOG000234044
HOVERGENiHBG079500
InParanoidiQ9DC11
OMAiRVIYEYH
OrthoDBiEOG091G0827
PhylomeDBiQ9DC11
TreeFamiTF314400

Miscellaneous databases

PROiPR:Q9DC11
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026748 Expressed in 275 organ(s), highest expression level in vestibular membrane of cochlear duct
CleanExiMM_PLXDC2
ExpressionAtlasiQ9DC11 baseline and differential
GenevisibleiQ9DC11 MM

Family and domain databases

InterProiView protein in InterPro
IPR002165 Plexin_repeat
IPR031152 PLXDC
IPR031154 PLXDC2
IPR016201 PSI
PANTHERiPTHR13055 PTHR13055, 1 hit
PTHR13055:SF11 PTHR13055:SF11, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
SMARTiView protein in SMART
SM00423 PSI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPXDC2_MOUSE
AccessioniPrimary (citable) accession number: Q9DC11
Secondary accession number(s): Q6PET5, Q91ZV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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