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Protein

LIM zinc-binding domain-containing Nebulette

Gene

Nebl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM zinc-binding domain-containing Nebulette
Alternative name(s):
Actin-binding Z-disk protein
Gene namesi
Name:Nebl
Synonyms:Lnebl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1921353 Nebl

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004175851 – 270LIM zinc-binding domain-containing NebuletteAdd BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei96Omega-N-methylarginineCombined sources1
Modified residuei132Omega-N-methylarginineCombined sources1
Modified residuei135PhosphothreonineCombined sources1
Modified residuei230PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9DC07
PaxDbiQ9DC07
PeptideAtlasiQ9DC07
PRIDEiQ9DC07

PTM databases

iPTMnetiQ9DC07

Expressioni

Gene expression databases

BgeeiENSMUSG00000053702
ExpressionAtlasiQ9DC07 baseline and differential
GenevisibleiQ9DC07 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9DC07, 1 interactor
MINTiQ9DC07
STRINGi10090.ENSMUSP00000028080

Structurei

3D structure databases

ProteinModelPortaliQ9DC07
SMRiQ9DC07
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 63LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST61
Repeati61 – 95Nebulin 1Add BLAST35
Repeati97 – 131Nebulin 2Add BLAST35
Repeati133 – 159Nebulin 3Add BLAST27
Domaini210 – 270SH3PROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

LIM domain, Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG1702 Eukaryota
ENOG4111GQ8 LUCA
GeneTreeiENSGT00530000062924
HOGENOMiHOG000006616
HOVERGENiHBG054636
OMAiCTPIDEG
PhylomeDBiQ9DC07

Family and domain databases

CDDicd11935 SH3_Nebulette_C, 1 hit
InterProiView protein in InterPro
IPR035631 Nebulette_SH3
IPR000900 Nebulin_repeat
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 1 hit
PF00880 Nebulin, 2 hits
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00132 LIM, 1 hit
SM00227 NEBU, 3 hits
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit
PS51216 NEBULIN, 3 hits
PS50002 SH3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms exist.
Isoform 2 (identifier: Q9DC07-1) [UniParc]FASTAAdd to basket
Also known as: LIM-Nebulette, LIM-NBEL, LNBEL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPQCARCGK VVYPTEKVNC LDKYWHKGCF HCEVCKMALN MNNYKGYEKK
60 70 80 90 100
PYCNAHYPKQ SFTTVADTPE NLRLKQQSEL QSQVKYKRDF EESKGRGFSI
110 120 130 140 150
VTDTPELQRL KRTQEQISNV KYHEDFEKTK GRGFTPVVDD PVTERVRKST
160 170 180 190 200
QVVSDAAYKG VQPHVVEMDR RPGIIVAPVL PGAYQQSHSQ GYGYMHQTSV
210 220 230 240 250
SSMRSMQPPA HLRTYRAMYD YSAQDEDEVS FRDGDYIVNV QPIDDGWMYG
260 270
TVQRTGRTGM LPANYIEFVN
Length:270
Mass (Da):31,113
Last modified:June 1, 2001 - v1
Checksum:i1CC9E10C04E49E4D
GO
Isoform 1 (identifier: Q0II04-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q0II04.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:452
Mass (Da):52,201
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004645 mRNA Translation: BAB23436.1
AL935297 Genomic DNA No translation available.
AL772218, AL845498, AL954131 Genomic DNA Translation: CAM14501.1
AL845498, AL772218, AL954131 Genomic DNA Translation: CAM17882.1
AL954131, AL772218, AL845498 Genomic DNA Translation: CAM21080.1
CH466542 Genomic DNA Translation: EDL08088.1
BC025863 mRNA Translation: AAH25863.1
CCDSiCCDS15706.1 [Q9DC07-1]
RefSeqiNP_083033.1, NM_028757.2 [Q9DC07-1]
UniGeneiMm.120298
Mm.256298
Mm.404039
Mm.440498
Mm.481799

Genome annotation databases

EnsembliENSMUST00000028080; ENSMUSP00000028080; ENSMUSG00000053702 [Q9DC07-1]
GeneIDi74103
KEGGimmu:74103
UCSCiuc008ila.1 mouse [Q9DC07-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLNEBL_MOUSE
AccessioniPrimary (citable) accession number: Q9DC07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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