Forkhead box protein P4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 14701752
• metal ion binding Source: UniProtKB-KW
• protein heterodimerization activity Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 14701752
• protein homodimerization activity Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 14701752
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 14701752
• transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 14701752

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• embryonic foregut morphogenesis Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 15361625
• heart development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 15361625
• lung secretory cell differentiation Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 22675208
• negative regulation of lung goblet cell differentiation Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 22675208
• negative regulation of transcription by RNA polymerase II Source: NTNU_SB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 14701752
• regulation of lung goblet cell differentiation Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 22675208
• transcription, DNA-templated Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• protein heterodimerization activity Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 14701752
• protein homodimerization activity Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 14701752

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Zinc finger

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MMVESASETI RSAPSGQNGV GSLSAQADGG GGAGTAGTAP AAGRDASGRE 
        60         70         80         90        100
AASGGADSNG EMSPAELLHF QQQQALQVAR QFLLQQASSL NSPGNNDSKQ 
       110        120        130        140        150
SASAVQVPVS VAMMSQQMLT PQQMQQILSP PQLQALLQQQ QALMLQQLQE 
       160        170        180        190        200
YYKKQQEQLH LQLLTQQQAG KQQPKEALGN KQLAFQQQLL QMQQLQQQHL 
       210        220        230        240        250
LNLQRQGLVS LQPSQASGPL QALPQAVCPT DLPQLWKGEG APGQPAEDSG 
       260        270        280        290        300
RQEGLDLAST AVTATSFASP PKVSPPLSHH PLPNGQPTVL TSRRDSSSHE 
       310        320        330        340        350
ETPSSHPLYG HGECKWPGCE TLCEDLGQFI KHLNTEHALD DRSTAQCRVQ 
       360        370        380        390        400
MQVVQQLEIQ LAKESERLQA MMAHLHMRPS EPKPFSQPVT VSADPFPDGL 
       410        420        430        440        450
VHPPTSAAAP VTPLRPPGLG SASLHSGGPA RRRSNDKFCS PISSELAQNH 
       460        470        480        490        500
EFYKNADVRP PFTYASLIRQ AILETPDRQL TLNEIYNWFT RMFAYFRRNT 
       510        520        530        540        550
ATWKNAVRHN LSLHKCFVRV ENVKGAVWTV DEREYQKRRP PKMTGSPTLV 
       560        570        580        590        600
KNMISGLSYG ALNASYQAAL AESSFPLLSN PGMLNPGSAS SLLPLSQEDL 
       610        620        630        640        650
GVPGEPLPSN GSSSPPRLSP PQYSHQIQVK EEPAEAEEDR RPGPPLGAPN 
       660        670        680        690        700
PSTVGPPEDR DLEEDLGGED MPSQPCPLIP GWKPSLLHLS YCVKPKFTVS 
       710        720        730        740        750
VGSKTPSSPL PPPPRVQGSY SLPPCSYLAY GDMRGQNPAP SPGLLSGVGG 
       760        770        780        790 
GLFRCLHRTK SPSLPGVWIL AAELETMRFH RPPMGDPQPK TADWV      

        10         20         30         40         50
MMVESASETI RSAPSGQNGV GSLSAQADGG GGAGTAGTAP AAGRDASGRE 
        60         70         80         90        100
AASGGADSNG EMSPAELLHF QQQQALQVAR QFLLQQASSL NSPGNNDSKQ 
       110        120        130        140        150
SASAVQVPVS VAMMSQQMLT PQQMQQILSP PQLQALLQQQ QALMLQQLQE 
       160        170        180        190        200
YYKKQQEQLH LQLLTQQQAG KQQPKEALGN KQLAFQQQLL QMQQLQQQHL 
       210        220        230        240        250
LNLQRQGLVS LQPSQASGPL QALPQAVCPT DLPQLWKGEG APGQPAEDSG 
       260        270        280        290        300
RQEGLDLAST AVTATSFASP PKVSPPLSHH PLPNGQPTVL TSRRDSSSHE 
       310        320        330        340        350
ETPSSHPLYG HGECKWPGCE TLCEDLGQFI KHLNTEHALD DRSTAQCRVQ 
       360        370        380        390        400
MQVVQQLEIQ LAKESERLQA MMAHLHMRPS EPKPFSQPVT VSADPFPDGL 
       410        420        430        440        450
VHPPTSAAAP VTPLRPPGLG SASLHSGGPA RRRSNDKFCS PISSELAQNH 
       460        470        480        490        500
EFYKNADVRP PFTYASLIRQ AILETPDRQL TLNEIYNWFT RMFAYFRRNT 
       510        520        530        540        550
ATWKNAVRHN LSLHKCFVRV ENVKGAVWTV DEREYQKRRP PKMTGSPTLV 
       560        570        580        590        600
KNMISGLSYG ALNASYQAAL AESSFPLLSN PGMLNPGSAS SLLPLSQEDL 
       610        620        630        640        650
GVPGEPLPSN GSSSPPRLSP PQYSHQIQVK EEPAEAEEDR RPGPPLGAPN 
       660        670 
PSTVGPPEDR DLEEDLGGED MS                               

        10         20         30         40         50
MMVESASETI RSAPSGQNGV GSLSAQADGG GGAGTAGTAP AAGRDASGRE 
        60         70         80         90        100
AASGGADSNG EMSPAELLHF QQQQALQVAR QFLLQQASSL NSPGNNDSKQ 
       110        120        130        140        150
SASAVQVPVS VAMMSQQMLT PQQMQQILSP PQLQALLQQQ QALMLQQLQE 
       160        170        180        190        200
YYKKQQEQLH LQLLTQQQAG KQQPKEALGN KQLAFQQQLL QMQQLQQQHL 
       210        220        230        240        250
LNLQRQGLVS LQPSQASGPL QALPQAVCPT DLPQLWKGEG APGQPAEDSG 
       260        270        280        290        300
RQEGLDLAST AVTATSFASP PKVSPPLSHH PLPNGQPTVL TSRRDSSSHE 
       310        320        330        340        350
ETPSSHPLYG HGECKWPGCE TLCEDLGQFI KHLNTEHALD DRSTAQCRVQ 
       360        370        380        390        400
MQVVQQLEIQ LAKESERLQA MMAHLHMRPS EPKPFSQPLN PVPGSSSFSK 
       410        420        430        440        450
VTVSADPFPD GLVHPPTSAA APVTPLRPPG LGSASLHSGG PARRRSNDKF 
       460        470        480        490        500
CSPISSELAQ NHEFYKNADV RPPFTYASLI RQAILETPDR QLTLNEIYNW 
       510        520        530        540        550
FTRMFAYFRR NTATWKNAVR HNLSLHKCFV RVENVKGAVW TVDEREYQKR 
       560        570        580        590        600
RPPKMTGSPT LVKNMISGLS YGALNASYQA ALAESSFPLL SNPGMLNPGS 
       610        620        630        640        650
ASSLLPLSQE DLGVPGEPLP SNGSSSPPRL SPPQYSHQIQ VKEEPAEAEE 
       660        670        680 
DRRPGPPLGA PNPSTVGPPE DRDLEEDLGG EDMS                  

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot