UniProtKB - Q9DBY0 (FOXP4_MOUSE)
Protein
Forkhead box protein P4
Gene
Foxp4
Organism
Mus musculus (Mouse)
Status
Functioni
Transcriptional repressor that represses lung-specific expression.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 312 – 337 | C2H2-typeSequence analysisAdd BLAST | 26 | |
DNA bindingi | 459 – 549 | Fork-headPROSITE-ProRule annotationAdd BLAST | 91 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- identical protein binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- embryonic foregut morphogenesis Source: MGI
- heart development Source: MGI
- lung secretory cell differentiation Source: MGI
- negative regulation of lung goblet cell differentiation Source: MGI
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of lung goblet cell differentiation Source: MGI
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Forkhead box protein P4Alternative name(s): Fork head-related protein-like A Short name: mFKHLA |
Gene namesi | Name:Foxp4Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1921373, Foxp4 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 366 | Missing : Loss of dimerization. Almost complete loss of DNA-binding. Reduced transcriptional repression activity. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247653 | 1 – 795 | Forkhead box protein P4Add BLAST | 795 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 58 | PhosphoserineBy similarity | 1 | |
Modified residuei | 92 | PhosphoserineBy similarity | 1 | |
Cross-linki | 181 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 383 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 546 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q9DBY0 |
PRIDEi | Q9DBY0 |
PTM databases
iPTMneti | Q9DBY0 |
PhosphoSitePlusi | Q9DBY0 |
Expressioni
Tissue specificityi
Expressed in the adult heart, brain, spleen lung, liver, kidney and testes.2 Publications
Developmental stagei
Expressed predominantly in the lung and brain during embryogenesis. Expressed in the lung epithelium and the mesenchyme immediately adjacent to the epithelium from 10.5 dpc. At 9.5 dpc, expressed in the foregut endoderm but not in the heart. At 16.5 and 18.5 dpc, expressed in both the proximal and distal airway epithelium. Also expressed in the developing gut. In the hindgut, primarily expressed in epithelial cells of the intestine and stomach. Expressed in the brain in a dynamic pattern. At 14.5 dpc, expressed at high levels in the intermediate zone of the neopallial cortex with lower levels in the surrounding cells. By 16.5 dpc, no longer expressed in the intermediate zone, but still present in the surrounding cells of the neopallial cortex.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000023991, Expressed in undifferentiated genital tubercle and 265 other tissues |
ExpressionAtlasi | Q9DBY0, baseline and differential |
Genevisiblei | Q9DBY0, MM |
Interactioni
Subunit structurei
Forms homodimers and heterodimers with FOXP1 and FOXP2. Dimerization is required for DNA-binding.
1 PublicationGO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 216509, 2 interactors |
IntActi | Q9DBY0, 1 interactor |
STRINGi | 10090.ENSMUSP00000094916 |
Miscellaneous databases
RNActi | Q9DBY0, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 354 – 375 | Leucine-zipperAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 71 – 225 | Gln-richSequence analysisAdd BLAST | 155 | |
Compositional biasi | 603 – 724 | Pro-richSequence analysisAdd BLAST | 122 |
Domaini
The leucine-zipper is required for dimerization and transcriptional repression.1 Publication
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 312 – 337 | C2H2-typeSequence analysisAdd BLAST | 26 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG4385, Eukaryota |
GeneTreei | ENSGT00940000158700 |
HOGENOMi | CLU_019502_3_1_1 |
InParanoidi | Q9DBY0 |
OrthoDBi | 836427at2759 |
PhylomeDBi | Q9DBY0 |
TreeFami | TF326978 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032354, FOXP-CC IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16159, FOXP-CC, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 11 Publication (identifier: Q9DBY0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMVESASETI RSAPSGQNGV GSLSAQADGG GGAGTAGTAP AAGRDASGRE
60 70 80 90 100
AASGGADSNG EMSPAELLHF QQQQALQVAR QFLLQQASSL NSPGNNDSKQ
110 120 130 140 150
SASAVQVPVS VAMMSQQMLT PQQMQQILSP PQLQALLQQQ QALMLQQLQE
160 170 180 190 200
YYKKQQEQLH LQLLTQQQAG KQQPKEALGN KQLAFQQQLL QMQQLQQQHL
210 220 230 240 250
LNLQRQGLVS LQPSQASGPL QALPQAVCPT DLPQLWKGEG APGQPAEDSG
260 270 280 290 300
RQEGLDLAST AVTATSFASP PKVSPPLSHH PLPNGQPTVL TSRRDSSSHE
310 320 330 340 350
ETPSSHPLYG HGECKWPGCE TLCEDLGQFI KHLNTEHALD DRSTAQCRVQ
360 370 380 390 400
MQVVQQLEIQ LAKESERLQA MMAHLHMRPS EPKPFSQPVT VSADPFPDGL
410 420 430 440 450
VHPPTSAAAP VTPLRPPGLG SASLHSGGPA RRRSNDKFCS PISSELAQNH
460 470 480 490 500
EFYKNADVRP PFTYASLIRQ AILETPDRQL TLNEIYNWFT RMFAYFRRNT
510 520 530 540 550
ATWKNAVRHN LSLHKCFVRV ENVKGAVWTV DEREYQKRRP PKMTGSPTLV
560 570 580 590 600
KNMISGLSYG ALNASYQAAL AESSFPLLSN PGMLNPGSAS SLLPLSQEDL
610 620 630 640 650
GVPGEPLPSN GSSSPPRLSP PQYSHQIQVK EEPAEAEEDR RPGPPLGAPN
660 670 680 690 700
PSTVGPPEDR DLEEDLGGED MPSQPCPLIP GWKPSLLHLS YCVKPKFTVS
710 720 730 740 750
VGSKTPSSPL PPPPRVQGSY SLPPCSYLAY GDMRGQNPAP SPGLLSGVGG
760 770 780 790
GLFRCLHRTK SPSLPGVWIL AAELETMRFH RPPMGDPQPK TADWV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J161 | A0A0R4J161_MOUSE | Forkhead box protein P4 | Foxp4 | 685 | Annotation score: | ||
A0A0R4J1I5 | A0A0R4J1I5_MOUSE | Forkhead box protein P4 | Foxp4 | 673 | Annotation score: | ||
D3Z726 | D3Z726_MOUSE | Forkhead box protein P4 | Foxp4 | 683 | Annotation score: | ||
A0A571BEN0 | A0A571BEN0_MOUSE | Forkhead box protein P4 | Foxp4 | 113 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 226 | A → AA in AAN08624 (Ref. 2) Curated | 1 | |
Sequence conflicti | 226 | A → AA in AAH43702 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 226 | A → AA in AAH52407 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_052129 | 388 | P → PLNPVPGSSSFSK in isoform 3. 2 Publications | 1 | |
Alternative sequenceiVSP_052130 | 672 | P → S in isoform 2 and isoform 3. 3 Publications | 1 | |
Alternative sequenceiVSP_052131 | 673 – 795 | Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST | 123 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY135029 mRNA Translation: AAN08624.1 AB052766 mRNA Translation: BAC53799.1 AK004693 mRNA Translation: BAB23479.1 BC043702 mRNA Translation: AAH43702.1 BC052407 mRNA Translation: AAH52407.1 BC057110 mRNA Translation: AAH57110.1 |
CCDSi | CCDS50135.1 [Q9DBY0-2] |
RefSeqi | NP_001104294.1, NM_001110824.1 NP_001104295.1, NM_001110825.1 NP_083043.2, NM_028767.2 [Q9DBY0-2] |
Genome annotation databases
Ensembli | ENSMUST00000113265; ENSMUSP00000108890; ENSMUSG00000023991 [Q9DBY0-2] ENSMUST00000229858; ENSMUSP00000155078; ENSMUSG00000116496 [Q9DBY0-2] |
GeneIDi | 74123 |
KEGGi | mmu:74123 |
UCSCi | uc008cwm.2, mouse [Q9DBY0-3] uc008cwn.2, mouse [Q9DBY0-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY135029 mRNA Translation: AAN08624.1 AB052766 mRNA Translation: BAC53799.1 AK004693 mRNA Translation: BAB23479.1 BC043702 mRNA Translation: AAH43702.1 BC052407 mRNA Translation: AAH52407.1 BC057110 mRNA Translation: AAH57110.1 |
CCDSi | CCDS50135.1 [Q9DBY0-2] |
RefSeqi | NP_001104294.1, NM_001110824.1 NP_001104295.1, NM_001110825.1 NP_083043.2, NM_028767.2 [Q9DBY0-2] |
3D structure databases
SMRi | Q9DBY0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 216509, 2 interactors |
IntActi | Q9DBY0, 1 interactor |
STRINGi | 10090.ENSMUSP00000094916 |
PTM databases
iPTMneti | Q9DBY0 |
PhosphoSitePlusi | Q9DBY0 |
Proteomic databases
PaxDbi | Q9DBY0 |
PRIDEi | Q9DBY0 |
Protocols and materials databases
Antibodypediai | 1453, 263 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000113265; ENSMUSP00000108890; ENSMUSG00000023991 [Q9DBY0-2] ENSMUST00000229858; ENSMUSP00000155078; ENSMUSG00000116496 [Q9DBY0-2] |
GeneIDi | 74123 |
KEGGi | mmu:74123 |
UCSCi | uc008cwm.2, mouse [Q9DBY0-3] uc008cwn.2, mouse [Q9DBY0-2] |
Organism-specific databases
CTDi | 116113 |
MGIi | MGI:1921373, Foxp4 |
Phylogenomic databases
eggNOGi | KOG4385, Eukaryota |
GeneTreei | ENSGT00940000158700 |
HOGENOMi | CLU_019502_3_1_1 |
InParanoidi | Q9DBY0 |
OrthoDBi | 836427at2759 |
PhylomeDBi | Q9DBY0 |
TreeFami | TF326978 |
Miscellaneous databases
BioGRID-ORCSi | 74123, 3 hits in 17 CRISPR screens |
ChiTaRSi | Foxp4, mouse |
PROi | PR:Q9DBY0 |
RNActi | Q9DBY0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000023991, Expressed in undifferentiated genital tubercle and 265 other tissues |
ExpressionAtlasi | Q9DBY0, baseline and differential |
Genevisiblei | Q9DBY0, MM |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR032354, FOXP-CC IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit PF16159, FOXP-CC, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit PS00028, ZINC_FINGER_C2H2_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FOXP4_MOUSE | |
Accessioni | Q9DBY0Primary (citable) accession number: Q9DBY0 Secondary accession number(s): Q80V92, Q8CG10, Q8CIS1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot