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Protein

Hairy/enhancer-of-split related with YRPW motif-like protein

Gene

Heyl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.By similarity2 Publications

Miscellaneous

Expression in nascent somites is reduced in mice lacking Notch signaling.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processNotch signaling pathway, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Hairy/enhancer-of-split related with YRPW motif-like protein
Alternative name(s):
Hairy and enhancer of split-related protein 3
Hairy-related transcription factor 3
Short name:
HRT-3
Short name:
mHRT3
Gene namesi
Name:Heyl
Synonyms:Hesr3, Hrt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1860511 Heyl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002864301 – 326Hairy/enhancer-of-split related with YRPW motif-like proteinAdd BLAST326

Proteomic databases

PaxDbiQ9DBX7
PRIDEiQ9DBX7

PTM databases

PhosphoSitePlusiQ9DBX7

Expressioni

Tissue specificityi

Expressed in heart and at lower levels in brain, lung, muscle, ovary and testis.1 Publication

Developmental stagei

Expressed in the presmitic mesoderm, the somites, the developing peripheral nervous system and arterial smooth muscle. Expressed in atrioventricular cushions from E9.5 to E12.5. Also expressed in developing retina.3 Publications

Inductioni

By activation of the Notch signaling pathway.

Gene expression databases

BgeeiENSMUSG00000032744 Expressed in 245 organ(s), highest expression level in ascending aorta
GenevisibleiQ9DBX7 MM

Interactioni

Subunit structurei

Interacts with HES1, HDAC1, NCOR1 and SIN3A (By similarity). Self-associates. Interacts with GATA4, GATA6, HEY1 and HEY2.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9DBX7, 2 interactors
STRINGi10090.ENSMUSP00000040576

Structurei

3D structure databases

ProteinModelPortaliQ9DBX7
SMRiQ9DBX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 98bHLHPROSITE-ProRule annotationAdd BLAST56
Domaini116 – 153OrangePROSITE-ProRule annotationAdd BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni42 – 111Transcriptional repression and interaction with NCOR1 and SIN3ABy similarityAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi162 – 307Pro-richAdd BLAST146

Sequence similaritiesi

Belongs to the HEY family.Curated

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
GeneTreeiENSGT00700000104130
HOGENOMiHOG000286035
HOVERGENiHBG003275
InParanoidiQ9DBX7
KOiK09091
OMAiMKRPKEP
OrthoDBiEOG091G0GBN
PhylomeDBiQ9DBX7
TreeFamiTF323617

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DBX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRPRAPSGS DGESDGPIDV GQENDLSQMA RPLTTPSPSQ MQARKKRRGI
60 70 80 90 100
IEKRRRDRIN SSLSELRRLV PTAFEKQGSS KLEKAEVLQM TVDHLKMLHA
110 120 130 140 150
SGGTGFFDAR ALAVDFRSIG FRECLTEVIR YLGVLEGPSS HADPVRIRLL
160 170 180 190 200
SHLKSYAAEM EPSPTTTSAL AFPVWPWSFL HSCPGLPSLN SQLAILGRVP
210 220 230 240 250
GPVLPSISSP PYPISALRSA PVHRPAGTIP PTRRNLLPSR GVTSTQRAHL
260 270 280 290 300
PERPAAPPPT ALDARAARSI VPIPPCSPTT APGAGKSDDN VSGSISSPCP
310 320
SGPTGRPAGA VFYHSWVSEI TEIGAF
Length:326
Mass (Da):34,929
Last modified:May 1, 2007 - v2
Checksum:iE7F71F1A1F8E00A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29M → V in BAB23482 (PubMed:16141072).Curated1
Sequence conflicti201G → S in AAF14547 (PubMed:10588864).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172288 mRNA Translation: AAF14547.1
AJ271868 mRNA Translation: CAB71347.1
AB093590 mRNA Translation: BAC55067.1
AK004697 mRNA Translation: BAB23482.1
AK028596 mRNA Translation: BAC26024.1
AK080822 mRNA Translation: BAC38037.1
AL606934 Genomic DNA No translation available.
BC130263 mRNA Translation: AAI30264.1
CCDSiCCDS18613.1
RefSeqiNP_038933.2, NM_013905.3
UniGeneiMm.103615

Genome annotation databases

EnsembliENSMUST00000040821; ENSMUSP00000040576; ENSMUSG00000032744
GeneIDi56198
KEGGimmu:56198
UCSCiuc008uoz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172288 mRNA Translation: AAF14547.1
AJ271868 mRNA Translation: CAB71347.1
AB093590 mRNA Translation: BAC55067.1
AK004697 mRNA Translation: BAB23482.1
AK028596 mRNA Translation: BAC26024.1
AK080822 mRNA Translation: BAC38037.1
AL606934 Genomic DNA No translation available.
BC130263 mRNA Translation: AAI30264.1
CCDSiCCDS18613.1
RefSeqiNP_038933.2, NM_013905.3
UniGeneiMm.103615

3D structure databases

ProteinModelPortaliQ9DBX7
SMRiQ9DBX7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DBX7, 2 interactors
STRINGi10090.ENSMUSP00000040576

PTM databases

PhosphoSitePlusiQ9DBX7

Proteomic databases

PaxDbiQ9DBX7
PRIDEiQ9DBX7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040821; ENSMUSP00000040576; ENSMUSG00000032744
GeneIDi56198
KEGGimmu:56198
UCSCiuc008uoz.1 mouse

Organism-specific databases

CTDi26508
MGIiMGI:1860511 Heyl

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
GeneTreeiENSGT00700000104130
HOGENOMiHOG000286035
HOVERGENiHBG003275
InParanoidiQ9DBX7
KOiK09091
OMAiMKRPKEP
OrthoDBiEOG091G0GBN
PhylomeDBiQ9DBX7
TreeFamiTF323617

Miscellaneous databases

PROiPR:Q9DBX7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032744 Expressed in 245 organ(s), highest expression level in ascending aorta
GenevisibleiQ9DBX7 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHEYL_MOUSE
AccessioniPrimary (citable) accession number: Q9DBX7
Secondary accession number(s): Q9JJV6, Q9QXW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 7, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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