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UniProtKB - Q9DBX5 (Q9DBX5_MOUSE)
Protein
Phospholipase A2
Gene
Pla2g4a
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H+ + hexadecanoate + sn-glycerol 3-phosphocholineARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+ARBA annotationEC:3.1.1.4ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phospholipase A2 activity Source: UniProtKB-EC
GO - Biological processi
- phospholipid catabolic process Source: InterPro
Keywordsi
Molecular function | HydrolasePROSITE-ProRule annotationARBA annotation |
Biological process | Lipid degradationPROSITE-ProRule annotation, Lipid metabolism |
Ligand | CalciumUniRule annotationARBA annotation, Metal-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Pla2g4aImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1195256, Pla2g4a |
VEuPathDBi | HostDB:ENSMUSG00000056220 |
Subcellular locationi
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
CytoplasmUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000056220, Expressed in indifferent gonad and 303 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 114 | C2InterPro annotationAdd BLAST | 114 | |
Domaini | 132 – 731 | PLA2cInterPro annotationAdd BLAST | 600 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 419 – 450 | DisorderedSequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 419 – 449 | Basic and acidic residuesSequence analysisAdd BLAST | 31 |
Domaini
The N-terminal C2 domain associates with lipid membranes upon calcium binding.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT01030000234606 |
Family and domain databases
CDDi | cd04036, C2_cPLA2, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR016035, Acyl_Trfase/lysoPLipase IPR041847, C2_cPLA2 IPR000008, C2_dom IPR035892, C2_domain_sf IPR002642, LysoPLipase_cat_dom |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF01735, PLA2_B, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00022, PLAc, 1 hit |
SUPFAMi | SSF49562, SSF49562, 1 hit SSF52151, SSF52151, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS51210, PLA2C, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9DBX5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFLVEHQYSH KFTVVVLRAT KVTKGTFGDM LDTPDPYVEL FISTTPDSRK
60 70 80 90 100
RTRHFNNDIN PVWNETFEFI LDPNQENVLE ITLMDANYVM DETLGTATFP
110 120 130 140 150
VSSMKVGEKK EVPFIFNQVT EMILEMSLEV CSCPDLRFSM ALCDQEKTFR
160 170 180 190 200
QQRKENIKEN MKKLLGPKKS EGLYSTRDVP VVAILGSGGG FRAMVGFSGV
210 220 230 240 250
MKALYESGIL DCATYIAGLS GSTWYMSTLY SHPDFPEKGP EEINEELMKN
260 270 280 290 300
VSHNPLLLLT PQKVKRYVES LWKKKSSGQP VTFTDIFGML IGETLIQNRM
310 320 330 340 350
SMTLSSLKEK VNAARCPLPL FTCLHVKPDV SELMFADWVE FSPYEIGMAK
360 370 380 390 400
YGTFMAPDLF GSKFFMGTVV KKYEENPLHF LMGVWGSAFS ILFNRVLGVS
410 420 430 440 450
GSQNKGSTME EELENITAKH IVSNDSSDSD DEAQGPKGTE NEEAEKEYQS
460 470 480 490 500
DNQASWVHRM LMALVSDSAL FNTREGRAGK VHNFMLGLNL NTSYPLSPLR
510 520 530 540 550
DFSSQDSFDD ELDAAVADPD EFERIYEPLD VKSKKIHVVD SGLTFNLPYP
560 570 580 590 600
LILRPQRGVD LIISFDFSAR PSDTSPPFKE LLLAEKWAKM NKLPFPKIDP
610 620 630 640 650
YVFDREGLKE CYVFKPKNPD VEKDCPTIIH FVLANINFRK YKAPGVLRET
660 670 680 690 700
KEEKEIADFD IFDDPESPFS TFNFQYPNQA FKRLHDLMYF NTLNNIDVIK
710 720 730 740
DAIVESIEYR RQNPSRCSVS LSNVEARKFF NKEFLSKPTV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP47713 | PA24A_MOUSE | Cytosolic phospholipase A2 | Pla2g4a Cpla2, Pla2g4 | 748 | Annotation score: | ||
A0A087WPN8 | A0A087WPN8_MOUSE | Cytosolic phospholipase A2 | Pla2g4a | 149 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK004701 mRNA Translation: BAB23486.1 |
RefSeqi | NP_001292561.1, NM_001305632.1 |
Genome annotation databases
Ensembli | ENSMUST00000111926; ENSMUSP00000107557; ENSMUSG00000056220 |
GeneIDi | 18783 |
UCSCi | uc056yeg.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK004701 mRNA Translation: BAB23486.1 |
RefSeqi | NP_001292561.1, NM_001305632.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 343397 |
Protocols and materials databases
Antibodypediai | 4104, 406 antibodies from 37 providers |
DNASUi | 18783 |
Genome annotation databases
Ensembli | ENSMUST00000111926; ENSMUSP00000107557; ENSMUSG00000056220 |
GeneIDi | 18783 |
UCSCi | uc056yeg.1, mouse |
Organism-specific databases
CTDi | 5321 |
MGIi | MGI:1195256, Pla2g4a |
VEuPathDBi | HostDB:ENSMUSG00000056220 |
Phylogenomic databases
GeneTreei | ENSGT01030000234606 |
Miscellaneous databases
BioGRID-ORCSi | 18783, 0 hits in 51 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000056220, Expressed in indifferent gonad and 303 other tissues |
Family and domain databases
CDDi | cd04036, C2_cPLA2, 1 hit |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR016035, Acyl_Trfase/lysoPLipase IPR041847, C2_cPLA2 IPR000008, C2_dom IPR035892, C2_domain_sf IPR002642, LysoPLipase_cat_dom |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF01735, PLA2_B, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00022, PLAc, 1 hit |
SUPFAMi | SSF49562, SSF49562, 1 hit SSF52151, SSF52151, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS51210, PLA2C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9DBX5_MOUSE | |
Accessioni | Q9DBX5Primary (citable) accession number: Q9DBX5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2001 |
Last sequence update: | June 1, 2001 | |
Last modified: | January 19, 2022 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |