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Protein

Matrix remodeling-associated protein 8

Gene

Mxra8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the maturation and maintenance of blood-brain barrier.1 Publication

GO - Biological processi

  • establishment of glial blood-brain barrier Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix remodeling-associated protein 8
Alternative name(s):
Adipocyte-specific protein 3
Limitrin
Gene namesi
Name:Mxra8
Synonyms:Asp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1922011 Mxra8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 340ExtracellularSequence analysisAdd BLAST321
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Topological domaini362 – 442CytoplasmicSequence analysisAdd BLAST81

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000029866620 – 442Matrix remodeling-associated protein 8Add BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 136PROSITE-ProRule annotation
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi185 ↔ 271PROSITE-ProRule annotation
Modified residuei227PhosphoserineBy similarity1
Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei324 – 325CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9DBV4
PaxDbiQ9DBV4
PRIDEiQ9DBV4

PTM databases

iPTMnetiQ9DBV4
PhosphoSitePlusiQ9DBV4
SwissPalmiQ9DBV4

Expressioni

Tissue specificityi

Expressed significantly in brain and localization is restricted to glia limitans which is formed by the endfeet of astrocytes surrounding capillaries and beneath the pia mater.1 Publication

Inductioni

Disruption of the blood-brain barrier by cold injury results in a drastic reduction in expression.1 Publication

Gene expression databases

BgeeiENSMUSG00000029070 Expressed in 272 organ(s), highest expression level in vault of skull
CleanExiMM_MXRA8
ExpressionAtlasiQ9DBV4 baseline and differential
GenevisibleiQ9DBV4 MM

Interactioni

Protein-protein interaction databases

BioGridi217001, 1 interactor
IntActiQ9DBV4, 1 interactor
MINTiQ9DBV4
STRINGi10090.ENSMUSP00000030947

Structurei

3D structure databases

ProteinModelPortaliQ9DBV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 156Ig-like V-type 1Add BLAST132
Domaini159 – 291Ig-like V-type 2Add BLAST133

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJVY Eukaryota
ENOG41113W9 LUCA
GeneTreeiENSGT00390000001509
HOGENOMiHOG000065729
HOVERGENiHBG058527
InParanoidiQ9DBV4
OMAiLLTCVNR
OrthoDBiEOG091G09TD
PhylomeDBiQ9DBV4
TreeFamiTF332884

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00406 IGv, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9DBV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELLSRVLLW KLLLLQSSAV LSSGPSGTAA ASSSLVSESV VSLAAGTQAV
60 70 80 90 100
LRCQSPRMVW TQDRLHDRQR VVHWDLSGGP GSQRRRLVDM YSAGEQRVYE
110 120 130 140 150
PRDRDRLLLS PSAFHDGNFS LLIRAVDRGD EGVYTCNLHH HYCHLDESLA
160 170 180 190 200
VRLEVTEDPL LSRAYWDGEK EVLVVAHGAP ALMTCINRAH VWTDRHLEEA
210 220 230 240 250
QQVVHWDRQL PGVSHDRADR LLDLYASGER RAYGPPFLRD RVSVNTNAFA
260 270 280 290 300
RGDFSLRIDE LERADEGIYS CHLHHHYCGL HERRVFHLQV TEPAFEPPAR
310 320 330 340 350
ASPGNGSGHS SAPSPDPTLT RGHSIINVIV PEDHTHFFQQ LGYVLATLLL
360 370 380 390 400
FILLLITVVL ATRYRHSGGC KTSDKKAGKS KGKDVNMVEF AVATRDQAPY
410 420 430 440
RTEDIQLDYK NNILKERAEL AHSPLPAKDV DLDKEFRKEY CK
Length:442
Mass (Da):49,750
Last modified:June 1, 2001 - v1
Checksum:i9600816B14AAA6EF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AD97A2AD97_MOUSE
Matrix-remodeling-associated protei...
Mxra8
311Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33S → N in BAD05133 (PubMed:14603461).Curated1
Sequence conflicti33S → N in BAB68501 (Ref. 2) Curated1
Sequence conflicti33S → N in AAH26438 (PubMed:15489334).Curated1
Sequence conflicti79G → D in BAD05133 (PubMed:14603461).Curated1
Sequence conflicti127D → E in BAD05133 (PubMed:14603461).Curated1
Sequence conflicti127D → E in BAB68501 (Ref. 2) Curated1
Sequence conflicti127D → E in AAH26438 (PubMed:15489334).Curated1
Sequence conflicti157E → D in BAD05133 (PubMed:14603461).Curated1
Sequence conflicti364Y → H in BAD05133 (PubMed:14603461).Curated1
Sequence conflicti364Y → H in BAB68501 (Ref. 2) Curated1
Sequence conflicti364Y → H in AAH26438 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052097 mRNA Translation: BAD05133.1
AB040488 mRNA Translation: BAB68501.1
AK004732 mRNA Translation: BAB23514.1
AL670236 Genomic DNA No translation available.
BC026438 mRNA Translation: AAH26438.1
CCDSiCCDS19044.1
RefSeqiNP_077225.4, NM_024263.4
UniGeneiMm.159028

Genome annotation databases

EnsembliENSMUST00000030947; ENSMUSP00000030947; ENSMUSG00000029070
GeneIDi74761
KEGGimmu:74761
UCSCiuc012dqy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052097 mRNA Translation: BAD05133.1
AB040488 mRNA Translation: BAB68501.1
AK004732 mRNA Translation: BAB23514.1
AL670236 Genomic DNA No translation available.
BC026438 mRNA Translation: AAH26438.1
CCDSiCCDS19044.1
RefSeqiNP_077225.4, NM_024263.4
UniGeneiMm.159028

3D structure databases

ProteinModelPortaliQ9DBV4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217001, 1 interactor
IntActiQ9DBV4, 1 interactor
MINTiQ9DBV4
STRINGi10090.ENSMUSP00000030947

PTM databases

iPTMnetiQ9DBV4
PhosphoSitePlusiQ9DBV4
SwissPalmiQ9DBV4

Proteomic databases

MaxQBiQ9DBV4
PaxDbiQ9DBV4
PRIDEiQ9DBV4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030947; ENSMUSP00000030947; ENSMUSG00000029070
GeneIDi74761
KEGGimmu:74761
UCSCiuc012dqy.1 mouse

Organism-specific databases

CTDi54587
MGIiMGI:1922011 Mxra8

Phylogenomic databases

eggNOGiENOG410IJVY Eukaryota
ENOG41113W9 LUCA
GeneTreeiENSGT00390000001509
HOGENOMiHOG000065729
HOVERGENiHBG058527
InParanoidiQ9DBV4
OMAiLLTCVNR
OrthoDBiEOG091G09TD
PhylomeDBiQ9DBV4
TreeFamiTF332884

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

PROiPR:Q9DBV4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029070 Expressed in 272 organ(s), highest expression level in vault of skull
CleanExiMM_MXRA8
ExpressionAtlasiQ9DBV4 baseline and differential
GenevisibleiQ9DBV4 MM

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00406 IGv, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMXRA8_MOUSE
AccessioniPrimary (citable) accession number: Q9DBV4
Secondary accession number(s): Q76M97, Q920S7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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