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Protein

Kinesin light chain 4

Gene

Klc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionMotor protein

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-5625970 RHO GTPases activate KTN1
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin light chain 4
Short name:
KLC 4
Alternative name(s):
Kinesin-like protein 8
Gene namesi
Name:Klc4
Synonyms:Knsl8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1922014 Klc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002150982 – 619Kinesin light chain 4Add BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei174PhosphoserineCombined sources1
Modified residuei460PhosphoserineBy similarity1
Modified residuei565PhosphoserineBy similarity1
Modified residuei566PhosphoserineCombined sources1
Modified residuei590PhosphoserineCombined sources1
Modified residuei612PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9DBS5
MaxQBiQ9DBS5
PaxDbiQ9DBS5
PeptideAtlasiQ9DBS5
PRIDEiQ9DBS5

PTM databases

iPTMnetiQ9DBS5
PhosphoSitePlusiQ9DBS5
SwissPalmiQ9DBS5

Expressioni

Gene expression databases

BgeeiENSMUSG00000003546 Expressed in 278 organ(s), highest expression level in jejunum
CleanExiMM_KLC4
GenevisibleiQ9DBS5 MM

Interactioni

Subunit structurei

Oligomeric complex composed of two heavy chains and two light chains.By similarity

Protein-protein interaction databases

BioGridi217004, 8 interactors
DIPiDIP-48704N
IntActiQ9DBS5, 10 interactors
MINTiQ9DBS5
STRINGi10090.ENSMUSP00000003642

Structurei

3D structure databases

ProteinModelPortaliQ9DBS5
SMRiQ9DBS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati55 – 88TPR 1Add BLAST34
Repeati211 – 244TPR 2Add BLAST34
Repeati253 – 286TPR 3Add BLAST34
Repeati295 – 328TPR 4Add BLAST34
Repeati337 – 370TPR 5Add BLAST34
Repeati379 – 412TPR 6Add BLAST34
Repeati464 – 497TPR 7Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili65 – 155Sequence analysisAdd BLAST91

Sequence similaritiesi

Belongs to the kinesin light chain family.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000006393
HOGENOMiHOG000261663
HOVERGENiHBG006217
InParanoidiQ9DBS5
KOiK10407
OMAiQHSGYEI
OrthoDBiEOG091G05DM
PhylomeDBiQ9DBS5
TreeFamiTF314010

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR002151 Kinesin_light
IPR015792 Kinesin_light_repeat
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PRINTSiPR00381 KINESINLIGHT
SMARTiView protein in SMART
SM00028 TPR, 5 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS01160 KINESIN_LIGHT, 3 hits
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DBS5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGLVLGQRD EPAGHRLSQE EILGSTKVVS QGLEALHSEH QAVLQSLSHT
60 70 80 90 100
IECLQQGGHE EGLVHEKARQ LRRSMENIEL GLSEAQVMLA LASHLSTVES
110 120 130 140 150
EKQKLRAQVR RLCQENQWLR DELAGTQQRL QRSEQAVAQL EEEKKHLEFL
160 170 180 190 200
RQLRQYDEDG HGMEEKEGEA TKDSLDDLFP NEEEEDSGND LSRGQGAAAA
210 220 230 240 250
QQGGYEIPAR LRTLHNLVIQ YAAQGRYEVA VPLCKQALED LERTSGRGHP
260 270 280 290 300
DVATMLNILA LVYRDQNKYK EAAHLLNDAL SIRESTLGRD HPAVAATLNN
310 320 330 340 350
LAVLYGKRGK YKEAEPLCQR ALEIREKVLG TDHPDVAKQL NNLALLCQNQ
360 370 380 390 400
GKYEAVERYY QRALAIYESQ LGPDNPNVAR TKNNLASCYL KQGKYSEAEA
410 420 430 440 450
LYKEILTCAH VQEFGSVDDD HKPIWMHAEE REEMSRSRPR DSSAPYAEYG
460 470 480 490 500
GWYKACRVSS PTVNTTLKNL GALYRRQGKL EAAETLEECA LRSRKQGTDP
510 520 530 540 550
ISQTKVAELL GEGDGRKAIQ EGPGDSVKFE GGEDASVAVE WSGDGSGTLQ
560 570 580 590 600
RSGSLGKIRD VLRRSSELLV RKLQGTEPRP SSSSMKRAAS LNYLNQPNAA
610
PLQVSRGLSA STVDLSSSS
Length:619
Mass (Da):68,613
Last modified:April 27, 2001 - v1
Checksum:iBE2D6B3CD451A7BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004774 mRNA Translation: BAB23552.1
AK170793 mRNA Translation: BAE42032.1
CCDSiCCDS28832.1
RefSeqiNP_083367.1, NM_029091.2
XP_006525106.1, XM_006525043.2
XP_011244990.1, XM_011246688.2
XP_011244991.1, XM_011246689.1
UniGeneiMm.279599

Genome annotation databases

EnsembliENSMUST00000003642; ENSMUSP00000003642; ENSMUSG00000003546
GeneIDi74764
KEGGimmu:74764
UCSCiuc008ctj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004774 mRNA Translation: BAB23552.1
AK170793 mRNA Translation: BAE42032.1
CCDSiCCDS28832.1
RefSeqiNP_083367.1, NM_029091.2
XP_006525106.1, XM_006525043.2
XP_011244990.1, XM_011246688.2
XP_011244991.1, XM_011246689.1
UniGeneiMm.279599

3D structure databases

ProteinModelPortaliQ9DBS5
SMRiQ9DBS5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217004, 8 interactors
DIPiDIP-48704N
IntActiQ9DBS5, 10 interactors
MINTiQ9DBS5
STRINGi10090.ENSMUSP00000003642

PTM databases

iPTMnetiQ9DBS5
PhosphoSitePlusiQ9DBS5
SwissPalmiQ9DBS5

Proteomic databases

EPDiQ9DBS5
MaxQBiQ9DBS5
PaxDbiQ9DBS5
PeptideAtlasiQ9DBS5
PRIDEiQ9DBS5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003642; ENSMUSP00000003642; ENSMUSG00000003546
GeneIDi74764
KEGGimmu:74764
UCSCiuc008ctj.1 mouse

Organism-specific databases

CTDi89953
MGIiMGI:1922014 Klc4

Phylogenomic databases

eggNOGiKOG1840 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000006393
HOGENOMiHOG000261663
HOVERGENiHBG006217
InParanoidiQ9DBS5
KOiK10407
OMAiQHSGYEI
OrthoDBiEOG091G05DM
PhylomeDBiQ9DBS5
TreeFamiTF314010

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-5625970 RHO GTPases activate KTN1
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Miscellaneous databases

ChiTaRSiKlc4 mouse
PROiPR:Q9DBS5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003546 Expressed in 278 organ(s), highest expression level in jejunum
CleanExiMM_KLC4
GenevisibleiQ9DBS5 MM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR002151 Kinesin_light
IPR015792 Kinesin_light_repeat
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PRINTSiPR00381 KINESINLIGHT
SMARTiView protein in SMART
SM00028 TPR, 5 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS01160 KINESIN_LIGHT, 3 hits
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLC4_MOUSE
AccessioniPrimary (citable) accession number: Q9DBS5
Secondary accession number(s): Q3TCC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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