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Protein

Transmembrane protein 43

Gene

Tmem43

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane.1 Publication

GO - Molecular functioni

  • protein self-association Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 43
Alternative name(s):
Protein LUMA
Gene namesi
Name:Tmem43
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1921372 Tmem43

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 31NuclearSequence analysisAdd BLAST30
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 313Perinuclear spaceSequence analysisAdd BLAST261
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 345NuclearSequence analysisAdd BLAST11
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Topological domaini367 – 368Perinuclear spaceSequence analysis2
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Topological domaini390 – 400NuclearSequence analysisAdd BLAST11

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002844992 – 400Transmembrane protein 43Add BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9DBS1
MaxQBiQ9DBS1
PaxDbiQ9DBS1
PeptideAtlasiQ9DBS1
PRIDEiQ9DBS1
TopDownProteomicsiQ9DBS1

PTM databases

PhosphoSitePlusiQ9DBS1
SwissPalmiQ9DBS1

Expressioni

Gene expression databases

BgeeiENSMUSG00000030095 Expressed in 246 organ(s), highest expression level in mammary gland
CleanExiMM_TMEM43
GenevisibleiQ9DBS1 MM

Interactioni

Subunit structurei

Can form oligomers through the transmembrane domains. Interacts with EMD; the interaction retains EMD at the inner nuclear membrane. Interacts with LMNA and LMNB2. Interacts with SUN2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216508, 1 interactor
IntActiQ9DBS1, 3 interactors
MINTiQ9DBS1
STRINGi10090.ENSMUSP00000032183

Structurei

3D structure databases

ProteinModelPortaliQ9DBS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM43 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEFK Eukaryota
ENOG410Z3TK LUCA
GeneTreeiENSGT00390000009671
HOGENOMiHOG000008164
HOVERGENiHBG062125
InParanoidiQ9DBS1
OMAiGDYFYHS
OrthoDBiEOG091G0A4D
PhylomeDBiQ9DBS1
TreeFamiTF324718

Family and domain databases

InterProiView protein in InterPro
IPR012430 TMEM43_fam
PANTHERiPTHR13416 PTHR13416, 1 hit
PfamiView protein in Pfam
PF07787 TMEM43, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DBS1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAANYSSTSS RKEHVKVTSE PQPGFLERLS ETSGGMFVGL MTFLLSFYLI
60 70 80 90 100
FTNEGRALKT ATSLAEGLSL VVSPDSIHSV APENEGRLVH IIGALRTSKL
110 120 130 140 150
LSDPNYGVHL PAVKLRRHVE MYQWVETEES SEYTEDGQVK KETKYSYNTE
160 170 180 190 200
WRSEIVNSRN FDREIGHKNP SAMAVESFTA TAPFVQIGRF FLSAGLIDKI
210 220 230 240 250
DNFKALSLAK LEDPHVDIIR RGDFFYHSEN PKYPEVGDVR VSFSYAGLSS
260 270 280 290 300
DDPDLGPAHV VTVIARQRGD QLIPYSTKSG DTLLLLHHGD FSAEEVFRRE
310 320 330 340 350
QKSNSMKTWG LRAAGWMAMF MGLNLMTRIL YTLVDWFPVF RDLVNIGLKA
360 370 380 390 400
FAFCVATSLT LLTVAAGWLF YRPLWAALIG CLALVPIIIA RTRVPAKKLE
Length:400
Mass (Da):44,783
Last modified:June 1, 2001 - v1
Checksum:i5A9732B4214D4316
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004778 mRNA Translation: BAB23556.1
AK151693 mRNA Translation: BAE30617.1
AK151766 mRNA Translation: BAE30672.1
AK152078 mRNA Translation: BAE30929.1
AK168559 mRNA Translation: BAE40432.1
BC024933 mRNA Translation: AAH24933.1
CCDSiCCDS20368.1
RefSeqiNP_083042.1, NM_028766.2
UniGeneiMm.38801

Genome annotation databases

EnsembliENSMUST00000032183; ENSMUSP00000032183; ENSMUSG00000030095
GeneIDi74122
KEGGimmu:74122
UCSCiuc009cyc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004778 mRNA Translation: BAB23556.1
AK151693 mRNA Translation: BAE30617.1
AK151766 mRNA Translation: BAE30672.1
AK152078 mRNA Translation: BAE30929.1
AK168559 mRNA Translation: BAE40432.1
BC024933 mRNA Translation: AAH24933.1
CCDSiCCDS20368.1
RefSeqiNP_083042.1, NM_028766.2
UniGeneiMm.38801

3D structure databases

ProteinModelPortaliQ9DBS1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216508, 1 interactor
IntActiQ9DBS1, 3 interactors
MINTiQ9DBS1
STRINGi10090.ENSMUSP00000032183

PTM databases

PhosphoSitePlusiQ9DBS1
SwissPalmiQ9DBS1

Proteomic databases

EPDiQ9DBS1
MaxQBiQ9DBS1
PaxDbiQ9DBS1
PeptideAtlasiQ9DBS1
PRIDEiQ9DBS1
TopDownProteomicsiQ9DBS1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032183; ENSMUSP00000032183; ENSMUSG00000030095
GeneIDi74122
KEGGimmu:74122
UCSCiuc009cyc.1 mouse

Organism-specific databases

CTDi79188
MGIiMGI:1921372 Tmem43

Phylogenomic databases

eggNOGiENOG410IEFK Eukaryota
ENOG410Z3TK LUCA
GeneTreeiENSGT00390000009671
HOGENOMiHOG000008164
HOVERGENiHBG062125
InParanoidiQ9DBS1
OMAiGDYFYHS
OrthoDBiEOG091G0A4D
PhylomeDBiQ9DBS1
TreeFamiTF324718

Miscellaneous databases

PROiPR:Q9DBS1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030095 Expressed in 246 organ(s), highest expression level in mammary gland
CleanExiMM_TMEM43
GenevisibleiQ9DBS1 MM

Family and domain databases

InterProiView protein in InterPro
IPR012430 TMEM43_fam
PANTHERiPTHR13416 PTHR13416, 1 hit
PfamiView protein in Pfam
PF07787 TMEM43, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMM43_MOUSE
AccessioniPrimary (citable) accession number: Q9DBS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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