Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Amyloid-beta A4 precursor protein-binding family B member 2

Gene

Apbb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate the internalization of amyloid-beta precursor protein.By similarity

GO - Molecular functioni

  • amyloid-beta binding Source: GO_Central
  • histone acetyltransferase binding Source: UniProtKB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid-beta A4 precursor protein-binding family B member 2
Gene namesi
Name:Apbb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:108405 Apbb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760531 – 760Amyloid-beta A4 precursor protein-binding family B member 2Add BLAST760

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei123PhosphoserineBy similarity1
Modified residuei160PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei412PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9DBR4
PRIDEiQ9DBR4

PTM databases

iPTMnetiQ9DBR4
PhosphoSitePlusiQ9DBR4

Expressioni

Gene expression databases

BgeeiENSMUSG00000029207 Expressed in 293 organ(s), highest expression level in cardiac ventricle
ExpressionAtlasiQ9DBR4 baseline and differential
GenevisibleiQ9DBR4 MM

Interactioni

Subunit structurei

Binds to the intracellular domain of the amyloid-beta precursor protein.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198142, 4 interactors
ELMiQ9DBR4
IntActiQ9DBR4, 1 interactor
MINTiQ9DBR4
STRINGi10090.ENSMUSP00000125211

Structurei

Secondary structure

1760
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9DBR4
SMRiQ9DBR4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DBR4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini290 – 322WWPROSITE-ProRule annotationAdd BLAST33
Domaini413 – 580PID 1PROSITE-ProRule annotationAdd BLAST168
Domaini586 – 738PID 2PROSITE-ProRule annotationAdd BLAST153

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEKA Eukaryota
ENOG410YEVS LUCA
GeneTreeiENSGT00390000000002
HOGENOMiHOG000033983
HOVERGENiHBG050524
InParanoidiQ9DBR4
KOiK04530
OMAiEKSQPGQ
PhylomeDBiQ9DBR4
TreeFamiTF314331

Family and domain databases

CDDicd00201 WW, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR039576 Fe65
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR001202 WW_dom
IPR036020 WW_dom_sf
PANTHERiPTHR14058 PTHR14058, 1 hit
PfamiView protein in Pfam
PF00640 PID, 2 hits
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 2 hits
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9DBR4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEVLPADSG VGTLAVFMAS SGSTDIANRN SPATPPNTLN LRSSHNELLN
60 70 80 90 100
AEIKHSDAKN STPPKCRKKY ALTNIQAAMG LSDPAVQPLL GNGSANIKLV
110 120 130 140 150
KNGENQLRKA AEQGQQDPNK NLSPAAVINL TSEKLEVKDP HPQESSGCEI
160 170 180 190 200
LPSQPRRTKS FLNYYADLET SARELGQNLG PCQGVGEEKA QPGPGQAPVV
210 220 230 240 250
IGNGDLLPQK PNKPQSSPED GQVATVSSSP ETKKDHPKTG AKTDCALHRI
260 270 280 290 300
QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVN
310 320 330 340 350
DIAGTYYWHI PTGTTQWERP VSIPADLHGS RKGSLSSVTP SPTPENEKQP
360 370 380 390 400
WSDFAVLNGG KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP
410 420 430 440 450
HGDDDDSCSI NSDPEAKCFA VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL
460 470 480 490 500
SYCKNDIRDT VGIWGEGKDM YLSLENDMLS LVDPMDRSVL HSQPIVNIRV
510 520 530 540 550
WGVGRDNGRE RDFAYVARDK DTRILKCHVF RCDTPAKAIA TSLHEICSKI
560 570 580 590 600
MAERKNAKAL ACSSLQERTN MSLDVPLQVD FPTPKTELVQ KFRVQYLGML
610 620 630 640 650
PVDRPVGMDT LNSAIENLMT SSSKEDWPSV NMNVADATVT VISEKNEEEV
660 670 680 690 700
LVECRVRFLS FMGVGKDVHT FAFIMDTGNQ RFECHVFWCE PNAANVSEAV
710 720 730 740 750
QAACMLRYQK CLVARPPSQK VRPPPPPADS VTRRVTTNVK RGVLSLIDTL
760
KQKRPVTETP
Length:760
Mass (Da):83,201
Last modified:March 1, 2003 - v2
Checksum:i9E66E34489F4D736
GO
Isoform 2 (identifier: Q9DBR4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.

Show »
Length:739
Mass (Da):80,815
Checksum:i5821BB835A62868C
GO
Isoform 3 (identifier: Q9DBR4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-368: Missing.
     509-510: Missing.

Show »
Length:737
Mass (Da):80,530
Checksum:i2A8C34E8176E223C
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PWH3E9PWH3_MOUSE
Amyloid-beta A4 precursor protein-b...
Apbb2
738Annotation score:
Q3TDW6Q3TDW6_MOUSE
Amyloid-beta A4 precursor protein-b...
Apbb2
736Annotation score:
Q3TIZ5Q3TIZ5_MOUSE
Amyloid-beta A4 precursor protein-b...
Apbb2
758Annotation score:
E9QPX0E9QPX0_MOUSE
Amyloid-beta A4 precursor protein-b...
Apbb2
760Annotation score:
F6V8Y6F6V8Y6_MOUSE
Amyloid-beta A4 precursor protein-b...
Apbb2
510Annotation score:
E0CYJ4E0CYJ4_MOUSE
Amyloid-beta A4 precursor protein-b...
Apbb2
107Annotation score:
E0CYY8E0CYY8_MOUSE
Amyloid-beta A4 precursor protein-b...
Apbb2
93Annotation score:
E0CZA9E0CZA9_MOUSE
Amyloid-beta A4 precursor protein-b...
Apbb2
102Annotation score:
E0CZ85E0CZ85_MOUSE
Amyloid-beta A4 precursor protein-b...
Apbb2
25Annotation score:
E0CYB2E0CYB2_MOUSE
Amyloid-beta A4 precursor protein-b...
Apbb2
12Annotation score:
There is more potential isoformShow all

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011661348 – 368Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_011662509 – 510Missing in isoform 3. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004792 mRNA Translation: BAB23568.2
BC076587 mRNA Translation: AAH76587.1
CCDSiCCDS51510.1 [Q9DBR4-1]
CCDS57344.1 [Q9DBR4-3]
RefSeqiNP_001188343.1, NM_001201414.1
NP_001188344.1, NM_001201415.1 [Q9DBR4-3]
NP_033816.1, NM_009686.2 [Q9DBR4-1]
UniGeneiMm.5159

Genome annotation databases

EnsembliENSMUST00000159786; ENSMUSP00000125211; ENSMUSG00000029207 [Q9DBR4-3]
ENSMUST00000162349; ENSMUSP00000123752; ENSMUSG00000029207 [Q9DBR4-1]
GeneIDi11787
KEGGimmu:11787
UCSCiuc008xpb.2 mouse [Q9DBR4-3]
uc033ijy.1 mouse [Q9DBR4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004792 mRNA Translation: BAB23568.2
BC076587 mRNA Translation: AAH76587.1
CCDSiCCDS51510.1 [Q9DBR4-1]
CCDS57344.1 [Q9DBR4-3]
RefSeqiNP_001188343.1, NM_001201414.1
NP_001188344.1, NM_001201415.1 [Q9DBR4-3]
NP_033816.1, NM_009686.2 [Q9DBR4-1]
UniGeneiMm.5159

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGUNMR-A582-704[»]
2ROZNMR-B582-704[»]
2YSZNMR-A582-704[»]
2YT0NMR-A582-704[»]
2YT1NMR-A582-704[»]
ProteinModelPortaliQ9DBR4
SMRiQ9DBR4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198142, 4 interactors
ELMiQ9DBR4
IntActiQ9DBR4, 1 interactor
MINTiQ9DBR4
STRINGi10090.ENSMUSP00000125211

PTM databases

iPTMnetiQ9DBR4
PhosphoSitePlusiQ9DBR4

Proteomic databases

PaxDbiQ9DBR4
PRIDEiQ9DBR4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000159786; ENSMUSP00000125211; ENSMUSG00000029207 [Q9DBR4-3]
ENSMUST00000162349; ENSMUSP00000123752; ENSMUSG00000029207 [Q9DBR4-1]
GeneIDi11787
KEGGimmu:11787
UCSCiuc008xpb.2 mouse [Q9DBR4-3]
uc033ijy.1 mouse [Q9DBR4-1]

Organism-specific databases

CTDi323
MGIiMGI:108405 Apbb2

Phylogenomic databases

eggNOGiENOG410IEKA Eukaryota
ENOG410YEVS LUCA
GeneTreeiENSGT00390000000002
HOGENOMiHOG000033983
HOVERGENiHBG050524
InParanoidiQ9DBR4
KOiK04530
OMAiEKSQPGQ
PhylomeDBiQ9DBR4
TreeFamiTF314331

Miscellaneous databases

ChiTaRSiApbb2 mouse
EvolutionaryTraceiQ9DBR4
PROiPR:Q9DBR4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029207 Expressed in 293 organ(s), highest expression level in cardiac ventricle
ExpressionAtlasiQ9DBR4 baseline and differential
GenevisibleiQ9DBR4 MM

Family and domain databases

CDDicd00201 WW, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR039576 Fe65
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR001202 WW_dom
IPR036020 WW_dom_sf
PANTHERiPTHR14058 PTHR14058, 1 hit
PfamiView protein in Pfam
PF00640 PID, 2 hits
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 2 hits
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPBB2_MOUSE
AccessioniPrimary (citable) accession number: Q9DBR4
Secondary accession number(s): Q6DFX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again