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Protein

Protein-associating with the carboxyl-terminal domain of ezrin

Gene

Scyl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in regulating cell adhesion/migration complexes in migrating cells.

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-associating with the carboxyl-terminal domain of ezrin
Alternative name(s):
Ezrin-binding protein PACE-1
SCY1-like protein 3
Gene namesi
Name:Scyl3
Synonyms:Pace1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1921385 Scyl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000581682 – 735Protein-associating with the carboxyl-terminal domain of ezrinAdd BLAST734

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei439PhosphoserineCombined sources1
Modified residuei701PhosphoserineBy similarity1

Post-translational modificationi

May be myristoylated; myristoylation may target it to Golgi compartment.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiQ9DBQ7
PeptideAtlasiQ9DBQ7
PRIDEiQ9DBQ7

PTM databases

iPTMnetiQ9DBQ7
PhosphoSitePlusiQ9DBQ7

Expressioni

Gene expression databases

BgeeiENSMUSG00000026584 Expressed in 241 organ(s), highest expression level in liver
CleanExiMM_SCYL3
ExpressionAtlasiQ9DBQ7 baseline and differential
GenevisibleiQ9DBQ7 MM

Interactioni

Subunit structurei

Interacts with EZR/VIL2 C-terminal domain.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027876

Structurei

3D structure databases

ProteinModelPortaliQ9DBQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 245Protein kinasePROSITE-ProRule annotationAdd BLAST244
Repeati194 – 249HEAT 1Add BLAST56
Repeati285 – 323HEAT 2Add BLAST39
Repeati333 – 370HEAT 3Add BLAST38
Repeati372 – 409HEAT 4Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni547 – 735Interaction with EZRBy similarityAdd BLAST189

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1243 Eukaryota
ENOG410XQTG LUCA
GeneTreeiENSGT00890000139451
HOGENOMiHOG000115424
HOVERGENiHBG053485
InParanoidiQ9DBQ7
KOiK17542
OMAiEWPDWSE
OrthoDBiEOG091G0B8M
PhylomeDBiQ9DBQ7
TreeFamiTF313435

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q9DBQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSENSALKS YTLRESPFTL PSGLAVYPAI LQDGKCASVF VYKRENEDKV
60 70 80 90 100
NKAAKHLKTL RHPCLLRFLS CTVEADGIHL VTERVQPLEV ALETLSPAEV
110 120 130 140 150
CAGIYDILLA LIFLHDRGHL THNNVCLSSV FVSEDGHWKL GGMETVCQVP
160 170 180 190 200
QATPEFLRNI QSVRDPASIP PEEMSPEFSG LPESHGHARD AYAFGALVDS
210 220 230 240 250
LLPIFNEQVS ADVLSSFLQI LHSALLNPMP ECRPALSTLL SHDFFRNDFL
260 270 280 290 300
EVVNFLKSLT LKSEDEKTEF FKFLLDRVSC LSEELIASRL VPLLLNQLVF
310 320 330 340 350
AEPVAVKSFL PYLLGPKKEN APGETPCLLS PALFQSRVIP VLLRLFEVHE
360 370 380 390 400
EHVRMVLLSH IEAYVEHFTQ EQLKKVILPQ VLLGLRDTSN SIVAITLRSL
410 420 430 440 450
AVLVSLLGPE VVVGGERTKI FKRTAPSFTK TSDLSPEGSP MHVVCSQQSR
460 470 480 490 500
VSKVLEDPSS NVFPKWLSGN VPSSSRKRIQ EECYSSLSQT GDQFSHTIKF
510 520 530 540 550
PMNGLSDVKN TSEDNGSFPA GSNKPEEWPD WSEPEEPEQQ PASIHRWPRE
560 570 580 590 600
PCDVAESQHT NLTAEEVTWD DGEASFGTEI NSTATASAPV PVTSGGQSTS
610 620 630 640 650
AALVPLTEES KPLQSSPSSK TSHRQHEEVK PPQVSQERPL KAPSGLGLGE
660 670 680 690 700
EFTIQVKKKP VQDPELDWFA DMIPEIKPSG TFLILPELRT EVMVPDKDNV
710 720 730
SSLMQFSSKF AATEMTEGEA EGWEGEELAW EDNNW
Length:735
Mass (Da):81,333
Last modified:January 23, 2007 - v3
Checksum:i13E6652AE93A4424
GO
Isoform 2 (identifier: Q9DBQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-99: HLKTLRHPCL...VALETLSPAE → MAFTSSLREC...LLSSFMTEDI
     100-735: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:99
Mass (Da):11,283
Checksum:i562162FBD40B9AF9
GO
Isoform 3 (identifier: Q9DBQ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     319-331: Missing.

Note: No experimental confirmation available.
Show »
Length:722
Mass (Da):80,024
Checksum:i1E536A38605B2A07
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6TFM1F6TFM1_MOUSE
Protein-associating with the carbox...
Scyl3
60Annotation score:

Sequence cautioni

The sequence BAC31777 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BC066800 differs from that shown. Reason: Erroneous termination at position 613. Translated as Leu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93E → Q in BAE37123 (PubMed:16141072).Curated1
Sequence conflicti226L → Q in BC066800 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03798556 – 99HLKTL…LSPAE → MAFTSSLRECSLWKWPWKPC LLQKSVLESMTYCWLLSSFM TEDI in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_013126100 – 735Missing in isoform 2. 1 PublicationAdd BLAST636
Alternative sequenceiVSP_027369319 – 331Missing in isoform 3. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004809 mRNA Translation: BAB23580.1
AK044100 mRNA Translation: BAC31777.1 Sequence problems.
AK050999 mRNA Translation: BAC34492.1
AK162937 mRNA Translation: BAE37123.1
BC043085 mRNA Translation: AAH43085.1
BC066800 mRNA No translation available.
CCDSiCCDS15430.1 [Q9DBQ7-1]
CCDS69967.1 [Q9DBQ7-3]
RefSeqiNP_001272931.1, NM_001286002.1 [Q9DBQ7-3]
NP_001272932.1, NM_001286003.1
NP_083052.1, NM_028776.5 [Q9DBQ7-1]
XP_006496912.1, XM_006496849.1
XP_017176061.1, XM_017320572.1
UniGeneiMm.389213

Genome annotation databases

EnsembliENSMUST00000027876; ENSMUSP00000027876; ENSMUSG00000026584 [Q9DBQ7-1]
ENSMUST00000161908; ENSMUSP00000125735; ENSMUSG00000026584 [Q9DBQ7-3]
ENSMUST00000162234; ENSMUSP00000123704; ENSMUSG00000026584 [Q9DBQ7-2]
ENSMUST00000170359; ENSMUSP00000132109; ENSMUSG00000026584 [Q9DBQ7-3]
GeneIDi240880
KEGGimmu:240880
UCSCiuc007dhq.2 mouse [Q9DBQ7-1]
uc011wuu.1 mouse [Q9DBQ7-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004809 mRNA Translation: BAB23580.1
AK044100 mRNA Translation: BAC31777.1 Sequence problems.
AK050999 mRNA Translation: BAC34492.1
AK162937 mRNA Translation: BAE37123.1
BC043085 mRNA Translation: AAH43085.1
BC066800 mRNA No translation available.
CCDSiCCDS15430.1 [Q9DBQ7-1]
CCDS69967.1 [Q9DBQ7-3]
RefSeqiNP_001272931.1, NM_001286002.1 [Q9DBQ7-3]
NP_001272932.1, NM_001286003.1
NP_083052.1, NM_028776.5 [Q9DBQ7-1]
XP_006496912.1, XM_006496849.1
XP_017176061.1, XM_017320572.1
UniGeneiMm.389213

3D structure databases

ProteinModelPortaliQ9DBQ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027876

PTM databases

iPTMnetiQ9DBQ7
PhosphoSitePlusiQ9DBQ7

Proteomic databases

PaxDbiQ9DBQ7
PeptideAtlasiQ9DBQ7
PRIDEiQ9DBQ7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027876; ENSMUSP00000027876; ENSMUSG00000026584 [Q9DBQ7-1]
ENSMUST00000161908; ENSMUSP00000125735; ENSMUSG00000026584 [Q9DBQ7-3]
ENSMUST00000162234; ENSMUSP00000123704; ENSMUSG00000026584 [Q9DBQ7-2]
ENSMUST00000170359; ENSMUSP00000132109; ENSMUSG00000026584 [Q9DBQ7-3]
GeneIDi240880
KEGGimmu:240880
UCSCiuc007dhq.2 mouse [Q9DBQ7-1]
uc011wuu.1 mouse [Q9DBQ7-3]

Organism-specific databases

CTDi57147
MGIiMGI:1921385 Scyl3

Phylogenomic databases

eggNOGiKOG1243 Eukaryota
ENOG410XQTG LUCA
GeneTreeiENSGT00890000139451
HOGENOMiHOG000115424
HOVERGENiHBG053485
InParanoidiQ9DBQ7
KOiK17542
OMAiEWPDWSE
OrthoDBiEOG091G0B8M
PhylomeDBiQ9DBQ7
TreeFamiTF313435

Miscellaneous databases

PROiPR:Q9DBQ7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026584 Expressed in 241 organ(s), highest expression level in liver
CleanExiMM_SCYL3
ExpressionAtlasiQ9DBQ7 baseline and differential
GenevisibleiQ9DBQ7 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPACE1_MOUSE
AccessioniPrimary (citable) accession number: Q9DBQ7
Secondary accession number(s): Q3TRA7
, Q6NY01, Q8BQC9, Q8BRJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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