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Protein

UMP-CMP kinase

Gene

Cmpk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.UniRule annotation

Catalytic activityi

ATP + (d)CMP = ADP + (d)CDP.UniRule annotation
ATP + UMP = ADP + UDP.UniRule annotation
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per monomer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39NMPUniRule annotation1
Binding sitei100CMPUniRule annotation1
Binding sitei134ATPUniRule annotation1
Binding sitei140NMPUniRule annotation1
Binding sitei151NMPUniRule annotation1
Binding sitei179ATP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 18ATPUniRule annotation6
Nucleotide bindingi61 – 63NMPUniRule annotation3
Nucleotide bindingi93 – 96NMPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processPyrimidine biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UMP-CMP kinaseUniRule annotation (EC:2.7.4.14UniRule annotation)
Alternative name(s):
Deoxycytidylate kinaseUniRule annotation
Short name:
CKUniRule annotation
Short name:
dCMP kinaseUniRule annotation
Nucleoside-diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
Uridine monophosphate/cytidine monophosphate kinaseUniRule annotation
Short name:
UMP/CMP kinaseUniRule annotation
Short name:
UMP/CMPKUniRule annotation
Gene namesi
Name:Cmpk1
Synonyms:Cmk, Cmpk, Uck, Umk, Umpk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1913838 Cmpk1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001589501 – 196UMP-CMP kinaseAdd BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineBy similarity1
Modified residuei43N6-acetyllysineCombined sources1
Modified residuei55N6-acetyllysineBy similarity1
Cross-linki73Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei106N6-succinyllysineCombined sources1
Modified residuei180PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9DBP5
MaxQBiQ9DBP5
PaxDbiQ9DBP5
PeptideAtlasiQ9DBP5
PRIDEiQ9DBP5
TopDownProteomicsiQ9DBP5

2D gel databases

REPRODUCTION-2DPAGEiIPI00331146
Q9DBP5
UCD-2DPAGEiQ9DBP5

PTM databases

iPTMnetiQ9DBP5
PhosphoSitePlusiQ9DBP5
SwissPalmiQ9DBP5

Expressioni

Gene expression databases

CleanExiMM_CMPK1

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

BioGridi211574, 1 interactor
IntActiQ9DBP5, 5 interactors
MINTiQ9DBP5
STRINGi10090.ENSMUSP00000030491

Structurei

3D structure databases

ProteinModelPortaliQ9DBP5
SMRiQ9DBP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni33 – 63NMPbindUniRule annotationAdd BLAST31
Regioni133 – 143LIDUniRule annotationAdd BLAST11

Domaini

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.UniRule annotation

Sequence similaritiesi

Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG3079 Eukaryota
COG0563 LUCA
HOGENOMiHOG000238771
HOVERGENiHBG108060
InParanoidiQ9DBP5
KOiK13800
PhylomeDBiQ9DBP5
TreeFamiTF354283

Family and domain databases

CDDicd01428 ADK, 1 hit
HAMAPiMF_00235 Adenylate_kinase_Adk, 1 hit
MF_03172 Adenylate_kinase_UMP_CMP_kin, 1 hit
InterProiView protein in InterPro
IPR000850 Adenylat/UMP-CMP_kin
IPR033690 Adenylat_kinase_CS
IPR027417 P-loop_NTPase
IPR006266 UMP_CMP_kinase
PANTHERiPTHR23359 PTHR23359, 1 hit
PRINTSiPR00094 ADENYLTKNASE
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01359 UMP_CMP_kin_fam, 1 hit
PROSITEiView protein in PROSITE
PS00113 ADENYLATE_KINASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9DBP5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPLVVFVLG GPGAGKGTQC ARIVEKYGYT HLSAGELLRD ERKNPDSQYG
60 70 80 90 100
ELIEKYIKEG KIVPVEITIS LLKREMDQTM AANAQKNKFL IDGFPRNQDN
110 120 130 140 150
LQGWNKTMDG KADVSFVLFF DCNNEICIER CLERGKSSGR SDDNRESLEK
160 170 180 190
RIQTYLESTK PIIDLYEEMG KVKKIDASKS VDEVFGEVVK IFDKEG
Length:196
Mass (Da):22,165
Last modified:June 1, 2001 - v1
Checksum:i7972B629D7542294
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J093A0A0R4J093_MOUSE
UMP-CMP kinase
Cmpk1 CMPK, CMPK1, mCG_16168
227Annotation score:
F6TY56F6TY56_MOUSE
UMP-CMP kinase
Cmpk1
42Annotation score:
D6RIL5D6RIL5_MOUSE
UMP-CMP kinase
Cmpk1
62Annotation score:

Sequence cautioni

The sequence AAH17684 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB22163 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC36852 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE27170 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE29352 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE36771 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM19996 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077534 mRNA Translation: BAC36852.1 Different initiation.
AK002526 mRNA Translation: BAB22163.1 Different initiation.
AL670035 Genomic DNA Translation: CAM19996.1 Different initiation.
AK162173 mRNA Translation: BAE36771.1 Different initiation.
AK150162 mRNA Translation: BAE29352.1 Different initiation.
AK146436 mRNA Translation: BAE27170.1 Different initiation.
AK004827 mRNA Translation: BAB23595.1
BC017684 mRNA Translation: AAH17684.1 Different initiation.
RefSeqiNP_079923.3, NM_025647.3
UniGeneiMm.294159

Genome annotation databases

GeneIDi66588
KEGGimmu:66588
UCSCiuc008ueg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077534 mRNA Translation: BAC36852.1 Different initiation.
AK002526 mRNA Translation: BAB22163.1 Different initiation.
AL670035 Genomic DNA Translation: CAM19996.1 Different initiation.
AK162173 mRNA Translation: BAE36771.1 Different initiation.
AK150162 mRNA Translation: BAE29352.1 Different initiation.
AK146436 mRNA Translation: BAE27170.1 Different initiation.
AK004827 mRNA Translation: BAB23595.1
BC017684 mRNA Translation: AAH17684.1 Different initiation.
RefSeqiNP_079923.3, NM_025647.3
UniGeneiMm.294159

3D structure databases

ProteinModelPortaliQ9DBP5
SMRiQ9DBP5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211574, 1 interactor
IntActiQ9DBP5, 5 interactors
MINTiQ9DBP5
STRINGi10090.ENSMUSP00000030491

PTM databases

iPTMnetiQ9DBP5
PhosphoSitePlusiQ9DBP5
SwissPalmiQ9DBP5

2D gel databases

REPRODUCTION-2DPAGEiIPI00331146
Q9DBP5
UCD-2DPAGEiQ9DBP5

Proteomic databases

EPDiQ9DBP5
MaxQBiQ9DBP5
PaxDbiQ9DBP5
PeptideAtlasiQ9DBP5
PRIDEiQ9DBP5
TopDownProteomicsiQ9DBP5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi66588
KEGGimmu:66588
UCSCiuc008ueg.2 mouse

Organism-specific databases

CTDi51727
MGIiMGI:1913838 Cmpk1

Phylogenomic databases

eggNOGiKOG3079 Eukaryota
COG0563 LUCA
HOGENOMiHOG000238771
HOVERGENiHBG108060
InParanoidiQ9DBP5
KOiK13800
PhylomeDBiQ9DBP5
TreeFamiTF354283

Miscellaneous databases

ChiTaRSiUck2 mouse
PROiPR:Q9DBP5
SOURCEiSearch...

Gene expression databases

CleanExiMM_CMPK1

Family and domain databases

CDDicd01428 ADK, 1 hit
HAMAPiMF_00235 Adenylate_kinase_Adk, 1 hit
MF_03172 Adenylate_kinase_UMP_CMP_kin, 1 hit
InterProiView protein in InterPro
IPR000850 Adenylat/UMP-CMP_kin
IPR033690 Adenylat_kinase_CS
IPR027417 P-loop_NTPase
IPR006266 UMP_CMP_kinase
PANTHERiPTHR23359 PTHR23359, 1 hit
PRINTSiPR00094 ADENYLTKNASE
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01359 UMP_CMP_kin_fam, 1 hit
PROSITEiView protein in PROSITE
PS00113 ADENYLATE_KINASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCY_MOUSE
AccessioniPrimary (citable) accession number: Q9DBP5
Secondary accession number(s): Q8BK17, Q8VD05, Q9DCS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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