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Protein

1-acylglycerol-3-phosphate O-acyltransferase ABHD5

Gene

Abhd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis (PubMed:16679289). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289). Involved in keratinocyte differentiation (PubMed:16679289). Regulates lipid droplet fusion (PubMed:26083785).2 Publications

Catalytic activityi

Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processDifferentiation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BRENDAi2.3.1.51 3474

Protein family/group databases

ESTHERimouse-abhd5 CGI-58_ABHD5_ABHD4
MEROPSiS33.975

Chemistry databases

SwissLipidsiSLP:000000283

Names & Taxonomyi

Protein namesi
Recommended name:
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (EC:2.3.1.51)
Alternative name(s):
Abhydrolase domain-containing protein 5
Lipid droplet-binding protein CGI-58
Short name:
Protein CGI-58
Gene namesi
Name:Abhd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914719 Abhd5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lipid droplet

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3259509

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000808671 – 3511-acylglycerol-3-phosphate O-acyltransferase ABHD5Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9DBL9
PeptideAtlasiQ9DBL9
PRIDEiQ9DBL9

PTM databases

iPTMnetiQ9DBL9
PhosphoSitePlusiQ9DBL9
SwissPalmiQ9DBL9

Expressioni

Tissue specificityi

Highly expressed in the adipose tissue and testes. Weakly expressed in the liver, muscle, kidney, and heart. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and hypothalamus in brain (at protein level).3 Publications

Gene expression databases

BgeeiENSMUSG00000032540 Expressed in 293 organ(s), highest expression level in inguinal mammary gland
CleanExiMM_ABHD5
ExpressionAtlasiQ9DBL9 baseline and differential
GenevisibleiQ9DBL9 MM

Interactioni

Subunit structurei

Interacts with ADRP (By similarity). Interacts with PLIN. Interacts with and PNPLA2. Interacts with PLIN5; promotes interaction with PNPLA2.By similarity4 Publications

Protein-protein interaction databases

BioGridi212211, 4 interactors
DIPiDIP-61642N
IntActiQ9DBL9, 1 interactor
STRINGi10090.ENSMUSP00000122274

Structurei

Secondary structure

1351
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9DBL9
SMRiQ9DBL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 184AB hydrolase-1Sequence analysisAdd BLAST106

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi329 – 334HXXXXD motif6

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4409 Eukaryota
COG0596 LUCA
GeneTreeiENSGT00390000016277
HOVERGENiHBG054445
InParanoidiQ9DBL9
KOiK13699
OMAiVPCTYKK
OrthoDBiEOG091G0AEW
PhylomeDBiQ9DBL9
TreeFamiTF314196

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PRINTSiPR00111 ABHYDROLASE
SUPFAMiSSF53474 SSF53474, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9DBL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKAMAAEEEV DSADAGGGSG WLTGWLPTWC PTSTSHLKEA EEKMLKCVPC
60 70 80 90 100
TYKKEPVRIS NGNRIWTLMF SHNISSKTPL VLLHGFGGGL GLWALNFEDL
110 120 130 140 150
STDRPVYAFD LLGFGRSSRP RFDSDAEEVE NQFVESIEEW RCALRLDKMI
160 170 180 190 200
LLGHNLGGFL AAAYSLKYPS RVSHLILVEP WGFPERPDLA DQERPIPVWI
210 220 230 240 250
RALGAALTPF NPLAGLRIAG PFGLSLVQRL RPDFKRKYSS MFEDDTVTEY
260 270 280 290 300
IYHCNVQTPS GETAFKNMTI PYGWAKRPML QRIGGLHPDI PVSVIFGARS
310 320 330 340 350
CIDGNSGTSI QSLRPKSYVK TIAILGAGHY VYADQPEEFN QKVKEICHTV

D
Length:351
Mass (Da):39,155
Last modified:June 1, 2001 - v1
Checksum:i04068BFB77D33E67
GO
Isoform 2 (identifier: Q9DBL9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-171: Missing.

Note: No experimental confirmation available.
Show »
Length:198
Mass (Da):21,846
Checksum:i724796B08B1653D0
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z7K3D3Z7K3_MOUSE
1-acylglycerol-3-phosphate O-acyltr...
Abhd5
127Annotation score:
H3BLJ0H3BLJ0_MOUSE
1-acylglycerol-3-phosphate O-acyltr...
Abhd5 mCG_22628
46Annotation score:
H3BKV1H3BKV1_MOUSE
1-acylglycerol-3-phosphate O-acyltr...
Abhd5
38Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01534519 – 171Missing in isoform 2. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004873 mRNA Translation: BAB23632.1
AK019488 mRNA Translation: BAB31755.2
AK050377 mRNA Translation: BAC34220.1
BC037063 mRNA Translation: AAH37063.1
CCDSiCCDS23646.1 [Q9DBL9-1]
RefSeqiNP_080455.1, NM_026179.2 [Q9DBL9-1]
XP_006512308.1, XM_006512245.3
UniGeneiMm.280254

Genome annotation databases

EnsembliENSMUST00000111497; ENSMUSP00000107123; ENSMUSG00000032540 [Q9DBL9-2]
ENSMUST00000156520; ENSMUSP00000122274; ENSMUSG00000032540 [Q9DBL9-1]
GeneIDi67469
KEGGimmu:67469
UCSCiuc009sew.1 mouse [Q9DBL9-1]
uc009sey.1 mouse [Q9DBL9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiABHD5_MOUSE
AccessioniPrimary (citable) accession number: Q9DBL9
Secondary accession number(s): Q9CTY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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