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Entry version 134 (16 Oct 2019)
Sequence version 1 (01 Jun 2001)
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Protein
Submitted name:

MCG18845, isoform CRA_d

Gene

Uba7

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1169408 ISG15 antiviral mechanism
R-MMU-5656169 Termination of translesion DNA synthesis
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MCG18845, isoform CRA_dImported
Submitted name:
Ubiquitin-activating enzyme E1-likeImported
Submitted name:
Ubiquitin-like modifier-activating enzyme 7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Uba7Imported
Synonyms:Ube1lImported
ORF Names:mCG_18845Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1349462 Uba7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032596 Expressed in 193 organ(s), highest expression level in bone marrow

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9DBK7, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000035216

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini846 – 973UBA_e1_CInterPro annotationAdd BLAST128

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili745 – 765Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2012 Eukaryota
COG0476 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161447

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000167329

KEGG Orthology (KO)

More...
KOi
K10698

Identification of Orthologs from Complete Genome Data

More...
OMAi
DTNQDMH

Database of Orthologous Groups

More...
OrthoDBi
91748at2759

TreeFam database of animal gene trees

More...
TreeFami
TF300586

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.2660, 1 hit
2.40.30.180, 1 hit
3.10.290.60, 1 hit
3.50.50.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032420 E1_4HB
IPR032418 E1_FCCH
IPR042302 E1_FCCH_sf
IPR000594 ThiF_NAD_FAD-bd
IPR018965 Ub-activating_enz_E1_C
IPR042449 Ub-E1_IAD_1
IPR038252 UBA_E1_C_sf
IPR019572 UBA_E1_Cys
IPR042063 Ubi_acti_E1_SCCH
IPR035985 Ubiquitin-activating_enz
IPR018075 UBQ-activ_enz_E1
IPR000011 UBQ/SUMO-activ_enz_E1-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16191 E1_4HB, 1 hit
PF16190 E1_FCCH, 1 hit
PF09358 E1_UFD, 1 hit
PF00899 ThiF, 2 hits
PF10585 UBA_e1_thiolCys, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01849 UBIQUITINACT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00985 UBA_e1_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF69572 SSF69572, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01408 Ube1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9DBK7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEELYSRQL YVLGLPAMQR IQEAKVLLCG LQGLGAEVAK NLVLTGVGSL
60 70 80 90 100
TLHDPHPTCW ADLAAQCFLS EESLGRNRAE ASQAQLAQLN EAVQISVHSG
110 120 130 140 150
DITEDLLQGF QVVVLTDSKL EDQLKVGPLC HKHGVRFLMA ETRGLVGRLF
160 170 180 190 200
CDFGEDFTVL DPTEVEPMTA AIQDISQGFP GIVTLRGDTK RHSFHDGDLV
210 220 230 240 250
IFSDIEGMVE LNSCSPQSVR VQKDGSLEIG DTTTFSRYLR GGVVTEVKRP
260 270 280 290 300
KTVRHKPLDI ALLQPHVVAQ NTQEVQRAHC LHQAFHVLHK FQQLHGRLPK
310 320 330 340 350
PWDPDDAETV VELAQDLEPL KGTEEESLDE ALLRTIALSS AGTLSPMAAI
360 370 380 390 400
MGGVAAQEVL KAISRKFMPL DQWLYFDALE CLPEDETLLP SPEDCQPRNC
410 420 430 440 450
RYDGQIAVFG TDLQEKLSDQ HYLLVGAGAI GCEMLKVFAL VGLGVRANGG
460 470 480 490 500
VTVADMDYIE RSNLSRQFLF RPKDVRRPKA EVAAAAAHRL NPDLRATPYT
510 520 530 540 550
CPLDPTTEDI YDDSFFSRVN GVVAALDSFQ ARHYVAARCT HYLKPLLEAG
560 570 580 590 600
TQGTWGSASV FVPYVTEAYR GPASDAASED APYPVCTLRH IPSSMEHSVQ
610 620 630 640 650
WAQDQFEGLF RLSTETINCY QQTCTSLSAT DRTETLALLQ QVMGVLRTRP
660 670 680 690 700
QTWQDCVVWA LGHWQLCFHD KVLEGGTQFS SGSNKCPHPL QFDPNHDMHF
710 720 730 740 750
LYVLAAANLY ARMHGLPGSQ SQPALRELLT RLLESDSRPQ NLFSAEHGQE
760 770 780 790 800
QLKELQETLD DWRKGPPLKP VLFVKDDDSN FHVDFVVAAT DLRCQNYGIL
810 820 830 840 850
PVNHARIKQI VGRIIPAIAT STAVVAGLLG LELYKVVSGL RSHGTFRHSY
860 870 880 890 900
LHLAENHFIR SAPSAPAVQS FRDLKWTCWD RLKVPAVQPE RTLKSLLAHL
910 920 930 940 950
QEEHGLKVEM LLHHQALLYS SGWSSEKQAQ HLCLRVTELV QHVTGWKPKP
960 970
GLKVLVFELS CEGEEEEMAF PPLHYEL
Length:977
Mass (Da):108,679
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97E24911AB74C936
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BJA7H3BJA7_MOUSE
Ubiquitin-like modifier-activating ...
Uba7
410Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BKY9H3BKY9_MOUSE
Ubiquitin-like modifier-activating ...
Uba7
102Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL731808 Genomic DNA No translation available.
BC138843 mRNA Translation: AAI38844.1
AK004894 mRNA Translation: BAB23650.1
CH466560 Genomic DNA Translation: EDL21244.1

NCBI Reference Sequences

More...
RefSeqi
NP_076227.1, NM_023738.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000035216; ENSMUSP00000035216; ENSMUSG00000032596

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
74153

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:74153

UCSC genome browser

More...
UCSCi
uc009rno.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731808 Genomic DNA No translation available.
BC138843 mRNA Translation: AAI38844.1
AK004894 mRNA Translation: BAB23650.1
CH466560 Genomic DNA Translation: EDL21244.1
RefSeqiNP_076227.1, NM_023738.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9DBK7, 2 interactors
STRINGi10090.ENSMUSP00000035216

Genome annotation databases

EnsembliENSMUST00000035216; ENSMUSP00000035216; ENSMUSG00000032596
GeneIDi74153
KEGGimmu:74153
UCSCiuc009rno.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7318
MGIiMGI:1349462 Uba7

Phylogenomic databases

eggNOGiKOG2012 Eukaryota
COG0476 LUCA
GeneTreeiENSGT00940000161447
HOGENOMiHOG000167329
KOiK10698
OMAiDTNQDMH
OrthoDBi91748at2759
TreeFamiTF300586

Enzyme and pathway databases

ReactomeiR-MMU-1169408 ISG15 antiviral mechanism
R-MMU-5656169 Termination of translesion DNA synthesis
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Uba7 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032596 Expressed in 193 organ(s), highest expression level in bone marrow

Family and domain databases

Gene3Di1.10.10.2660, 1 hit
2.40.30.180, 1 hit
3.10.290.60, 1 hit
3.50.50.80, 1 hit
InterProiView protein in InterPro
IPR032420 E1_4HB
IPR032418 E1_FCCH
IPR042302 E1_FCCH_sf
IPR000594 ThiF_NAD_FAD-bd
IPR018965 Ub-activating_enz_E1_C
IPR042449 Ub-E1_IAD_1
IPR038252 UBA_E1_C_sf
IPR019572 UBA_E1_Cys
IPR042063 Ubi_acti_E1_SCCH
IPR035985 Ubiquitin-activating_enz
IPR018075 UBQ-activ_enz_E1
IPR000011 UBQ/SUMO-activ_enz_E1-like
PfamiView protein in Pfam
PF16191 E1_4HB, 1 hit
PF16190 E1_FCCH, 1 hit
PF09358 E1_UFD, 1 hit
PF00899 ThiF, 2 hits
PF10585 UBA_e1_thiolCys, 1 hit
PRINTSiPR01849 UBIQUITINACT
SMARTiView protein in SMART
SM00985 UBA_e1_C, 1 hit
SUPFAMiSSF69572 SSF69572, 2 hits
TIGRFAMsiTIGR01408 Ube1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9DBK7_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9DBK7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 16, 2019
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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