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Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Gene

Baiap2l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
Short name:
BAI1-associated protein 2-like protein 1
Alternative name(s):
Insulin receptor tyrosine kinase substrate
Gene namesi
Name:Baiap2l1
Synonyms:Irtks
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1914148 Baiap2l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002478551 – 514Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1Add BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248PhosphothreonineCombined sources1
Modified residuei257PhosphothreonineCombined sources1
Modified residuei261PhosphoserineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei332PhosphoserineBy similarity1
Modified residuei411PhosphothreonineBy similarity1
Modified residuei413PhosphoserineBy similarity1
Modified residuei419PhosphoserineBy similarity1
Modified residuei421PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine in response to insulin.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9DBJ3
PaxDbiQ9DBJ3
PeptideAtlasiQ9DBJ3
PRIDEiQ9DBJ3

PTM databases

iPTMnetiQ9DBJ3
PhosphoSitePlusiQ9DBJ3

Expressioni

Tissue specificityi

Detected in bladder, liver, testes, heart, lung, spleen, brain and skeletal muscle (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000038859 Expressed in 218 organ(s), highest expression level in secondary oocyte
CleanExiMM_BAIAP2L1
GenevisibleiQ9DBJ3 MM

Interactioni

Subunit structurei

Interacts with RAC1. Binds to F-actin. Interacts with FASLG (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9DBJ3, 2 interactors
MINTiQ9DBJ3
STRINGi10090.ENSMUSP00000053129

Structurei

Secondary structure

1514
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9DBJ3
SMRiQ9DBJ3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DBJ3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 249IMDPROSITE-ProRule annotationAdd BLAST249
Domaini340 – 403SH3PROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni486 – 514Binds F-actinBy similarityAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili115 – 148Sequence analysisAdd BLAST34

Domaini

The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity).By similarity

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiENOG410IGQC Eukaryota
ENOG410Y6FF LUCA
GeneTreeiENSGT00390000005995
HOGENOMiHOG000038005
HOVERGENiHBG054462
InParanoidiQ9DBJ3
KOiK20127
OMAiHCSFANH
OrthoDBiEOG091G05ZV
PhylomeDBiQ9DBJ3
TreeFamiTF325648

Family and domain databases

CDDicd11913 SH3_BAIAP2L1, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR013606 I-BAR_dom
IPR027681 IRSp53/IRTKS/Pinkbar
IPR030060 IRTKS
IPR035592 IRTKS_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR14206 PTHR14206, 1 hit
PTHR14206:SF4 PTHR14206:SF4, 1 hit
PfamiView protein in Pfam
PF08397 IMD, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51338 IMD, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DBJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRGPEEVNR LTENTYRNVM EQFNPGLRNL INLGKNYEKA VNAMILAGKA
60 70 80 90 100
YYDGVAKIGE IATGSPVSTE LGHVLIEISS THKKLNETLD ENFKKFHKDI
110 120 130 140 150
IHELEKKTEL DVKYMNATLK RYQAEHRNKL DSLEKSQAEL KKIRRKSQGG
160 170 180 190 200
RNALKYEHKE IEYVETVTSR QSEIQKFIAD GCKEALLEEK RRFCFLVDKH
210 220 230 240 250
CSFASHIHYY HMQSAELLNS KLPRWQETCC DATKVPEKIM NMIEEIKTPI
260 270 280 290 300
STPVSGTPQP SPMIERSKMI GKDYDTLSKY SPKMPPAPSV KAYTSPLIDM
310 320 330 340 350
FNNPATAAQS SEKTNNSTAN TGEDPSLQRS VSVATGLNMM KKQKVKTIFP
360 370 380 390 400
HTAGNNKTLL SFAQGDVLTL LIPEEKDGWL YGEHDTTKAR GWFPSSYTKL
410 420 430 440 450
LEENEAMSVP TPSPAPVRSI STVDLTEKSS VVIPPPDYLE CLSMGATSDK
460 470 480 490 500
KAGAPKVPSA STFRAPVSRP DATSTSPSDA NGTAKPPFLS GENPFATVKL
510
RPTVTNDRSA PIIR
Length:514
Mass (Da):57,188
Last modified:June 1, 2001 - v1
Checksum:iAF9974A0696812EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004918 mRNA Translation: BAB23669.1
BC015459 mRNA Translation: AAH15459.1
CCDSiCCDS39378.1
RefSeqiNP_080109.1, NM_025833.3
UniGeneiMm.18814

Genome annotation databases

EnsembliENSMUST00000055190; ENSMUSP00000053129; ENSMUSG00000038859
GeneIDi66898
KEGGimmu:66898
UCSCiuc009alq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004918 mRNA Translation: BAB23669.1
BC015459 mRNA Translation: AAH15459.1
CCDSiCCDS39378.1
RefSeqiNP_080109.1, NM_025833.3
UniGeneiMm.18814

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SPKNMR-A343-401[»]
ProteinModelPortaliQ9DBJ3
SMRiQ9DBJ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DBJ3, 2 interactors
MINTiQ9DBJ3
STRINGi10090.ENSMUSP00000053129

PTM databases

iPTMnetiQ9DBJ3
PhosphoSitePlusiQ9DBJ3

Proteomic databases

MaxQBiQ9DBJ3
PaxDbiQ9DBJ3
PeptideAtlasiQ9DBJ3
PRIDEiQ9DBJ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055190; ENSMUSP00000053129; ENSMUSG00000038859
GeneIDi66898
KEGGimmu:66898
UCSCiuc009alq.1 mouse

Organism-specific databases

CTDi55971
MGIiMGI:1914148 Baiap2l1

Phylogenomic databases

eggNOGiENOG410IGQC Eukaryota
ENOG410Y6FF LUCA
GeneTreeiENSGT00390000005995
HOGENOMiHOG000038005
HOVERGENiHBG054462
InParanoidiQ9DBJ3
KOiK20127
OMAiHCSFANH
OrthoDBiEOG091G05ZV
PhylomeDBiQ9DBJ3
TreeFamiTF325648

Miscellaneous databases

EvolutionaryTraceiQ9DBJ3
PROiPR:Q9DBJ3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038859 Expressed in 218 organ(s), highest expression level in secondary oocyte
CleanExiMM_BAIAP2L1
GenevisibleiQ9DBJ3 MM

Family and domain databases

CDDicd11913 SH3_BAIAP2L1, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR013606 I-BAR_dom
IPR027681 IRSp53/IRTKS/Pinkbar
IPR030060 IRTKS
IPR035592 IRTKS_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR14206 PTHR14206, 1 hit
PTHR14206:SF4 PTHR14206:SF4, 1 hit
PfamiView protein in Pfam
PF08397 IMD, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51338 IMD, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBI2L1_MOUSE
AccessioniPrimary (citable) accession number: Q9DBJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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