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Protein

Bardet-Biedl syndrome 10 protein homolog

Gene

Bbs10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis. Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bardet-Biedl syndrome 10 protein homolog
Gene namesi
Name:Bbs10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1919019 Bbs10

Subcellular locationi

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352731 – 713Bardet-Biedl syndrome 10 protein homologAdd BLAST713

Proteomic databases

PaxDbiQ9DBI2
PeptideAtlasiQ9DBI2
PRIDEiQ9DBI2

PTM databases

iPTMnetiQ9DBI2
PhosphoSitePlusiQ9DBI2

Expressioni

Gene expression databases

BgeeiENSMUSG00000035759 Expressed in 165 organ(s), highest expression level in dorsal pancreas
CleanExiMM_BBS10
GenevisibleiQ9DBI2 MM

Interactioni

Subunit structurei

Component of a complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8.By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60356N
IntActiQ9DBI2, 4 interactors
STRINGi10090.ENSMUSP00000049387

Structurei

3D structure databases

ProteinModelPortaliQ9DBI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0360 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00390000002417
HOGENOMiHOG000050242
HOVERGENiHBG055802
InParanoidiQ9DBI2
KOiK19401
OMAiAKTFIIF
OrthoDBiEOG091G0H6P
PhylomeDBiQ9DBI2
TreeFamiTF335867

Family and domain databases

Gene3Di1.10.560.10, 2 hits
3.30.260.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 2 hits
SUPFAMiSSF48592 SSF48592, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DBI2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASQGSVTAA LRVAEVLESI ANRCVGPEGG QVLCTKPTGE VLLSRDGGCL
60 70 80 90 100
LEALHLEHPL ARMIVACVSS HLKKTGDGAK TFIIFLCHLL RGLHAIGEKG
110 120 130 140 150
KDSFTSENIQ SHERHWKNCC QWKSISQALQ TFQTQTLGCI VDRSLSRHYL
160 170 180 190 200
SVFSSSTEGR KLCRHSLELL LEAYFCGRVG RNNHRFISQL MCDYVFKCMA
210 220 230 240 250
CESGVEVFEL LDHCFAELNV GVTGLPVSDS RIIDGLVLPR DFSMYCPADG
260 270 280 290 300
DIRMVIVTEI LQPQFSSAGS EFVLNSETQF QASQCWITDR TKTVMNHLRG
310 320 330 340 350
QNVKLLLTSV KQPDLVIYCA RLNSISVVEC LSAEEVSLVQ RITGLSPCVL
360 370 380 390 400
PEVASQCEIS DSTLVKFCKP LILRSKRYVH LGLISTCAFI PHSMVLCGPV
410 420 430 440 450
LGLVEQHERA FHGAFKMLRQ LFTDLDLNYI IQTKQQCNPS PLAYDNSRER
460 470 480 490 500
NHSPETDKYQ DIVAKSKNKL ETQTHLEVYS GLGASDTELR AGKPWSAHKK
510 520 530 540 550
TPIAPSQTDE MLKCLPPERS GIIDNCDLSI ENHSTGNPTA EDTGTEISFE
560 570 580 590 600
HLQVSDNAGK GYTLPVMRKS LDTCTCQGYC SSTVPAGCVL PVGGSFEILM
610 620 630 640 650
SYYLLSYAKQ CRQSDETVIS MLIADALLGI PKILYKPKKG KDSFPHIYMR
660 670 680 690 700
SLHALQASQP MVSGQSGFES VAGKYQLLTS VLQCLMKILT IDLIINIKRQ
710
PQKTADQESE DEF
Length:713
Mass (Da):78,924
Last modified:May 16, 2006 - v2
Checksum:iAEEBC611994FDB84
GO

Sequence cautioni

The sequence BAB23682 differs from that shown. Intron retention. Several introns.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004937 mRNA Translation: BAB23682.1 Sequence problems.
CCDSiCCDS48689.1
RefSeqiNP_082190.1, NM_027914.1
UniGeneiMm.45256

Genome annotation databases

EnsembliENSMUST00000040454; ENSMUSP00000049387; ENSMUSG00000035759
GeneIDi71769
KEGGimmu:71769
UCSCiuc011xnf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004937 mRNA Translation: BAB23682.1 Sequence problems.
CCDSiCCDS48689.1
RefSeqiNP_082190.1, NM_027914.1
UniGeneiMm.45256

3D structure databases

ProteinModelPortaliQ9DBI2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60356N
IntActiQ9DBI2, 4 interactors
STRINGi10090.ENSMUSP00000049387

PTM databases

iPTMnetiQ9DBI2
PhosphoSitePlusiQ9DBI2

Proteomic databases

PaxDbiQ9DBI2
PeptideAtlasiQ9DBI2
PRIDEiQ9DBI2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040454; ENSMUSP00000049387; ENSMUSG00000035759
GeneIDi71769
KEGGimmu:71769
UCSCiuc011xnf.1 mouse

Organism-specific databases

CTDi79738
MGIiMGI:1919019 Bbs10

Phylogenomic databases

eggNOGiKOG0360 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00390000002417
HOGENOMiHOG000050242
HOVERGENiHBG055802
InParanoidiQ9DBI2
KOiK19401
OMAiAKTFIIF
OrthoDBiEOG091G0H6P
PhylomeDBiQ9DBI2
TreeFamiTF335867

Miscellaneous databases

ChiTaRSiBbs10 mouse
PROiPR:Q9DBI2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035759 Expressed in 165 organ(s), highest expression level in dorsal pancreas
CleanExiMM_BBS10
GenevisibleiQ9DBI2 MM

Family and domain databases

Gene3Di1.10.560.10, 2 hits
3.30.260.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 2 hits
SUPFAMiSSF48592 SSF48592, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBBS10_MOUSE
AccessioniPrimary (citable) accession number: Q9DBI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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