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Entry version 173 (02 Jun 2021)
Sequence version 4 (14 Oct 2008)
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Protein

Transmembrane protease serine 6

Gene

Tmprss6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Membrane-bound serine protease (PubMed:18451267).

Through the cleavage of cell surface HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis (PubMed:18451267).

1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei617Charge relay systemBy similarity1
Active sitei668Charge relay systemBy similarity1
Active sitei762Charge relay systemBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.21.109, 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1442490, Collagen degradation
R-MMU-1474228, Degradation of the extracellular matrix

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.308

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protease serine 6 (EC:3.4.21.-)
Alternative name(s):
Matriptase-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tmprss6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1919003, Tmprss6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 59CytoplasmicSequence analysisAdd BLAST59
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei60 – 80Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini81 – 811ExtracellularSequence analysisAdd BLAST731

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice display the phenotype named mask, characterized by progressive loss of body (but not facial) hair, microcytic anemia and female infertility, all reversible by dietary iron supplementation. The mask phenotype results from reduced absorption of dietary iron caused by high levels of hepcidin.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi762S → A: Protease-dead. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000886971 – 811Transmembrane protease serine 6Add BLAST811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi335 ↔ 366By similarity
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi453N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi458 ↔ 470By similarity
Disulfide bondi464 ↔ 480By similarity
Disulfide bondi474 ↔ 489By similarity
Disulfide bondi491 ↔ 503By similarity
Disulfide bondi497 ↔ 516By similarity
Disulfide bondi510 ↔ 525By similarity
Glycosylationi518N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi531 ↔ 543By similarity
Disulfide bondi538 ↔ 557By similarity
Disulfide bondi551 ↔ 566By similarity
Disulfide bondi602 ↔ 618By similarity
Disulfide bondi702 ↔ 768By similarity
Disulfide bondi733 ↔ 747By similarity
Disulfide bondi758 ↔ 787By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The single-chain zymogen undergoes autoproteolytic processing. This results in TMPRSS6 shedding from the cell surface and conversion into an activated two-chains form which is released extracellularly. The process involves a trans-activation mechanism that requires TMPRSS6 oligomerization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9DBI0

PeptideAtlas

More...
PeptideAtlasi
Q9DBI0

PRoteomics IDEntifications database

More...
PRIDEi
Q9DBI0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
260709 [Q9DBI0-1]
260710 [Q9DBI0-2]
260711 [Q9DBI0-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9DBI0, 7 sites

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9DBI0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at highest levels in adult mice liver, kidney and uterus. Also strongly expressed within the nasal cavity by olfactory epithelial cells. A weak, but detectable, signal in adult mice tissues analyzed including brain, lung, heart, kidney, spleen, muscle, intestine, thymus and pancreas. No signal in residual embryonic yolk sac, developing kidney tubules or in embryonic tissues analyzed including lung, heart, gastrointestinal tract and epithelium of the oral cavity.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at higher levels from 12.5 dpc to 15.5 dpc with a peak at 13.5 dpc. Expressed in the developing liver and at lower levels in developing pharyngo-tympanic tubes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000016942, Expressed in liver and 111 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9DBI0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9DBI0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HJV.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
214901, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q9DBI0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000017086

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9DBI0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9DBI0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini86 – 209SEAPROSITE-ProRule annotationAdd BLAST124
Domaini213 – 336CUB 1PROSITE-ProRule annotationAdd BLAST124
Domaini323 – 440CUB 2PROSITE-ProRule annotationAdd BLAST118
Domaini445 – 477LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST33
Domaini478 – 514LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST37
Domaini518 – 555LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST38
Domaini577 – 811Peptidase S1PROSITE-ProRule annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 48DisorderedSequence analysisAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi33 – 48Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Cytoplasmic domain mediates HAMP suppression via proximal promoter element(s).1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3627, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160104

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006842_19_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9DBI0

Identification of Orthologs from Complete Genome Data

More...
OMAi
GWRNQGS

Database of Orthologous Groups

More...
OrthoDBi
1314811at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9DBI0

TreeFam database of animal gene trees

More...
TreeFami
TF330647

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 3 hits
cd00190, Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 1 hit
2.60.120.290, 1 hit
3.30.70.960, 1 hit
4.10.400.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR036055, LDL_receptor-like_sf
IPR002172, LDrepeatLR_classA_rpt
IPR017118, Pept_S1A_matriptase-2
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR000082, SEA_dom
IPR036364, SEA_dom_sf
IPR035914, Sperma_CUB_dom_sf
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00057, Ldl_recept_a, 2 hits
PF01390, SEA, 1 hit
PF00089, Trypsin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037135, Matriptase-2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00722, CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00192, LDLa, 3 hits
SM00020, Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 2 hits
SSF50494, SSF50494, 1 hit
SSF57424, SSF57424, 3 hits
SSF82671, SSF82671, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180, CUB, 1 hit
PS01209, LDLRA_1, 2 hits
PS50068, LDLRA_2, 3 hits
PS50024, SEA, 1 hit
PS50240, TRYPSIN_DOM, 1 hit
PS00134, TRYPSIN_HIS, 1 hit
PS00135, TRYPSIN_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9DBI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRCFQLPCS TRMPTTEVPQ AADGQGDAGD GEEAAEPEGK FKPPKNTKRK
60 70 80 90 100
NRDYVRFTPL LLVLAALVSA GVMLWYFLGY KAEVTVSQVY SGSLRVLNRH
110 120 130 140 150
FSQDLGRRES IAFRSESAKA QKMLQELVAS TRLGTYYNSS SVYSFGEGPL
160 170 180 190 200
TCFFWFILDI PEYQRLTLSP EVVRELLVDE LLSNSSTLAS YKTEYEVDPE
210 220 230 240 250
GLVILEASVN DIVVLNSTLG CYRYSYVNPG QVLPLKGPDQ QTTSCLWHLQ
260 270 280 290 300
GPEDLMIKVR LEWTRVDCRD RVAMYDAAGP LEKRLITSVY GCSRQEPVME
310 320 330 340 350
VLASGSVMAV VWKKGMHSYY DPFLLSVKSV AFQDCQVNLT LEGRLDTQGF
360 370 380 390 400
LRTPYYPSYY SPSTHCSWHL TVPSLDYGLA LWFDAYALRR QKYNRLCTQG
410 420 430 440 450
QWMIQNRRLC GFRTLQPYAE RIPMVASDGV TINFTSQISL TGPGVQVYYS
460 470 480 490 500
LYNQSDPCPG EFLCSVNGLC VPACDGIKDC PNGLDERNCV CRAMFQCQED
510 520 530 540 550
STCISLPRVC DRQPDCLNGS DEEQCQEGVP CGTFTFQCED RSCVKKPNPE
560 570 580 590 600
CDGQSDCRDG SDEQHCDCGL QGLSSRIVGG TVSSEGEWPW QASLQIRGRH
610 620 630 640 650
ICGGALIADR WVITAAHCFQ EDSMASPKLW TVFLGKMRQN SRWPGEVSFK
660 670 680 690 700
VSRLFLHPYH EEDSHDYDVA LLQLDHPVVY SATVRPVCLP ARSHFFEPGQ
710 720 730 740 750
HCWITGWGAQ REGGPVSNTL QKVDVQLVPQ DLCSEAYRYQ VSPRMLCAGY
760 770 780 790 800
RKGKKDACQG DSGGPLVCRE PSGRWFLAGL VSWGLGCGRP NFFGVYTRVT
810
RVINWIQQVL T
Length:811
Mass (Da):90,978
Last modified:October 14, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i32EB3E7C3127801B
GO
Isoform 2 (identifier: Q9DBI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     567-594: DCGLQGLSSRIVGGTVSSEGEWPWQASL → AWPPRSCGPCSWERCGRTRAGQARCPSR
     595-811: Missing.

Show »
Length:594
Mass (Da):66,733
Checksum:i036E77DA7D7DA21D
GO
Isoform 3 (identifier: Q9DBI0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     567-581: DCGLQGLSSRIVGGT → GPLQPYCGRDRVLRG
     582-811: Missing.

Show »
Length:581
Mass (Da):65,287
Checksum:iDE658EC33C9B1E03
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8W6T9A0A2R8W6T9_MOUSE
Transmembrane protease serine 6
Tmprss6
799Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8W6U1A0A2R8W6U1_MOUSE
Transmembrane protease serine 6
Tmprss6
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8VHU4A0A2R8VHU4_MOUSE
Transmembrane protease serine 6
Tmprss6
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH57674 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti690P → PP in BAB23684 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_035564567 – 594DCGLQ…WQASL → AWPPRSCGPCSWERCGRTRA GQARCPSR in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_035565567 – 581DCGLQ…IVGGT → GPLQPYCGRDRVLRG in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_035566582 – 811Missing in isoform 3. 1 PublicationAdd BLAST230
Alternative sequenceiVSP_035567595 – 811Missing in isoform 2. 1 PublicationAdd BLAST217

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY240929 mRNA Translation: AAP69827.1
EU190436 mRNA Translation: ABW38782.1
EU190437 mRNA Translation: ABW38783.1
AK004939 mRNA Translation: BAB23684.2
AL590144 Genomic DNA No translation available.
BC029645 mRNA Translation: AAH29645.2
BC057674 mRNA Translation: AAH57674.1 Different initiation.
BK000520 Genomic DNA Translation: DAA00246.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS37133.1 [Q9DBI0-1]

NCBI Reference Sequences

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RefSeqi
NP_082178.2, NM_027902.2 [Q9DBI0-1]
XP_006521479.1, XM_006521416.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000017086; ENSMUSP00000017086; ENSMUSG00000016942 [Q9DBI0-1]
ENSMUST00000229516; ENSMUSP00000155355; ENSMUSG00000016942 [Q9DBI0-2]
ENSMUST00000230159; ENSMUSP00000155549; ENSMUSG00000016942 [Q9DBI0-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
71753

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:71753

UCSC genome browser

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UCSCi
uc007wpi.1, mouse [Q9DBI0-1]
uc011zvt.1, mouse [Q9DBI0-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY240929 mRNA Translation: AAP69827.1
EU190436 mRNA Translation: ABW38782.1
EU190437 mRNA Translation: ABW38783.1
AK004939 mRNA Translation: BAB23684.2
AL590144 Genomic DNA No translation available.
BC029645 mRNA Translation: AAH29645.2
BC057674 mRNA Translation: AAH57674.1 Different initiation.
BK000520 Genomic DNA Translation: DAA00246.1
CCDSiCCDS37133.1 [Q9DBI0-1]
RefSeqiNP_082178.2, NM_027902.2 [Q9DBI0-1]
XP_006521479.1, XM_006521416.2

3D structure databases

SMRiQ9DBI0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi214901, 11 interactors
IntActiQ9DBI0, 1 interactor
STRINGi10090.ENSMUSP00000017086

Protein family/group databases

MEROPSiS01.308

PTM databases

GlyGeniQ9DBI0, 7 sites
PhosphoSitePlusiQ9DBI0

Proteomic databases

PaxDbiQ9DBI0
PeptideAtlasiQ9DBI0
PRIDEiQ9DBI0
ProteomicsDBi260709 [Q9DBI0-1]
260710 [Q9DBI0-2]
260711 [Q9DBI0-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
25860, 153 antibodies

The DNASU plasmid repository

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DNASUi
71753

Genome annotation databases

EnsembliENSMUST00000017086; ENSMUSP00000017086; ENSMUSG00000016942 [Q9DBI0-1]
ENSMUST00000229516; ENSMUSP00000155355; ENSMUSG00000016942 [Q9DBI0-2]
ENSMUST00000230159; ENSMUSP00000155549; ENSMUSG00000016942 [Q9DBI0-3]
GeneIDi71753
KEGGimmu:71753
UCSCiuc007wpi.1, mouse [Q9DBI0-1]
uc011zvt.1, mouse [Q9DBI0-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
164656
MGIiMGI:1919003, Tmprss6

Phylogenomic databases

eggNOGiKOG3627, Eukaryota
GeneTreeiENSGT00940000160104
HOGENOMiCLU_006842_19_3_1
InParanoidiQ9DBI0
OMAiGWRNQGS
OrthoDBi1314811at2759
PhylomeDBiQ9DBI0
TreeFamiTF330647

Enzyme and pathway databases

BRENDAi3.4.21.109, 3474
ReactomeiR-MMU-1442490, Collagen degradation
R-MMU-1474228, Degradation of the extracellular matrix

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
71753, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tmprss6, mouse

Protein Ontology

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PROi
PR:Q9DBI0
RNActiQ9DBI0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000016942, Expressed in liver and 111 other tissues
ExpressionAtlasiQ9DBI0, baseline and differential
GenevisibleiQ9DBI0, MM

Family and domain databases

CDDicd00112, LDLa, 3 hits
cd00190, Tryp_SPc, 1 hit
Gene3Di2.40.10.10, 1 hit
2.60.120.290, 1 hit
3.30.70.960, 1 hit
4.10.400.10, 3 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR036055, LDL_receptor-like_sf
IPR002172, LDrepeatLR_classA_rpt
IPR017118, Pept_S1A_matriptase-2
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR000082, SEA_dom
IPR036364, SEA_dom_sf
IPR035914, Sperma_CUB_dom_sf
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER
PfamiView protein in Pfam
PF00057, Ldl_recept_a, 2 hits
PF01390, SEA, 1 hit
PF00089, Trypsin, 1 hit
PIRSFiPIRSF037135, Matriptase-2, 1 hit
PRINTSiPR00722, CHYMOTRYPSIN
SMARTiView protein in SMART
SM00192, LDLa, 3 hits
SM00020, Tryp_SPc, 1 hit
SUPFAMiSSF49854, SSF49854, 2 hits
SSF50494, SSF50494, 1 hit
SSF57424, SSF57424, 3 hits
SSF82671, SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS01180, CUB, 1 hit
PS01209, LDLRA_1, 2 hits
PS50068, LDLRA_2, 3 hits
PS50024, SEA, 1 hit
PS50240, TRYPSIN_DOM, 1 hit
PS00134, TRYPSIN_HIS, 1 hit
PS00135, TRYPSIN_SER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMPS6_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9DBI0
Secondary accession number(s): A8W478
, A8W479, Q3KN88, Q6PF94
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 14, 2008
Last modified: June 2, 2021
This is version 173 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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