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Protein

Vesicular integral-membrane protein VIP36

Gene

Lman2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98CarbohydratePROSITE-ProRule annotation1
Binding sitei133CarbohydratePROSITE-ProRule annotation1
Metal bindingi164CalciumPROSITE-ProRule annotation1
Metal bindingi166Calcium; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi168CalciumPROSITE-ProRule annotation1
Binding sitei192CarbohydratePROSITE-ProRule annotation1
Metal bindingi195CalciumPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • endoplasmic reticulum organization Source: GO_Central
  • ER to Golgi vesicle-mediated transport Source: GO_Central
  • Golgi organization Source: GO_Central
  • positive regulation of phagocytosis Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • retrograde vesicle-mediated transport, Golgi to ER Source: MGI

Keywordsi

Biological processProtein transport, Transport
LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-5694530 Cargo concentration in the ER

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular integral-membrane protein VIP36
Alternative name(s):
Lectin mannose-binding 2
Vesicular integral-membrane protein 36
Short name:
VIP36
Gene namesi
Name:Lman2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1914140 Lman2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini47 – 324LumenalSequence analysisAdd BLAST278
Transmembranei325 – 347HelicalSequence analysisAdd BLAST23
Topological domaini348 – 358CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 46Sequence analysisAdd BLAST46
ChainiPRO_000001766747 – 358Vesicular integral-membrane protein VIP36Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi185N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi204 ↔ 241PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9DBH5
MaxQBiQ9DBH5
PaxDbiQ9DBH5
PeptideAtlasiQ9DBH5
PRIDEiQ9DBH5
TopDownProteomicsiQ9DBH5

PTM databases

PhosphoSitePlusiQ9DBH5
SwissPalmiQ9DBH5

Expressioni

Gene expression databases

BgeeiENSMUSG00000021484 Expressed in 293 organ(s), highest expression level in embryo
CleanExiMM_LMAN2
GenevisibleiQ9DBH5 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211791, 1 interactor
IntActiQ9DBH5, 5 interactors
MINTiQ9DBH5
STRINGi10090.ENSMUSP00000021940

Structurei

3D structure databases

ProteinModelPortaliQ9DBH5
SMRiQ9DBH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 278L-type lectin-likePROSITE-ProRule annotationAdd BLAST225

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 168Carbohydrate bindingPROSITE-ProRule annotation3
Regioni262 – 264Carbohydrate bindingPROSITE-ProRule annotation3

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3839 Eukaryota
ENOG410YH8V LUCA
GeneTreeiENSGT00530000062977
HOGENOMiHOG000164540
HOVERGENiHBG052334
InParanoidiQ9DBH5
KOiK10082
OMAiDNFEGLG
OrthoDBiEOG091G0AZ1
TreeFamiTF313311

Family and domain databases

CDDicd06901 lectin_VIP36_VIPL, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR005052 Lectin_leg
IPR035664 VIP36_lectin
PfamiView protein in Pfam
PF03388 Lectin_leg-like, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51328 L_LECTIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DBH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAEAWLWRW GWGWGQRCPG RPGLPGPGPS PTTFLHLLLL LGPVAADITD
60 70 80 90 100
GNSEHLKREH SLIKPYQGVG SSSMPLWDFQ GSTMLTSQYV RLTPDERSKE
110 120 130 140 150
GSIWNHQPCF LKDWEMHVHF KVHGTGKKNL HGDGIALWYT RDRLVPGPVF
160 170 180 190 200
GSKDNFHGLA IFLDTYPNDE TTERVFPYIS VMVNNGSLSY DHSKDGRWSE
210 220 230 240 250
LAGCTADFRN RDHDTFLAVR YSRGRLTVMT DLEDKNEWKN CIDITGVRLP
260 270 280 290 300
TGYYFGASAG TGDLSDNHDI ISIKLFQLTV ERTPEEESID WTKIEPGVNF
310 320 330 340 350
LKSPKDNVDD PTGNFRNGPL TGWRVFLLLL CALLGVVVCA VVGAVVFQKR

QERNKRFY
Length:358
Mass (Da):40,430
Last modified:July 27, 2011 - v2
Checksum:i14FB29BF3FDD3B54
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219V → L in BAB29313 (PubMed:16141072).Curated1
Sequence conflicti328L → V in BAB23695 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004952 mRNA Translation: BAB23695.1
AK014384 mRNA Translation: BAB29313.1
AK083442 mRNA Translation: BAC38916.1
AK150383 mRNA Translation: BAE29514.1
AK166953 mRNA Translation: BAE39136.1
AK169401 mRNA Translation: BAE41147.1
CH466546 Genomic DNA Translation: EDL41187.1
BC049221 mRNA Translation: AAH49221.1
BC055327 mRNA Translation: AAH55327.1
CCDSiCCDS26544.1
RefSeqiNP_080104.2, NM_025828.3
UniGeneiMm.38868

Genome annotation databases

EnsembliENSMUST00000021940; ENSMUSP00000021940; ENSMUSG00000021484
GeneIDi66890
KEGGimmu:66890
UCSCiuc007qqo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004952 mRNA Translation: BAB23695.1
AK014384 mRNA Translation: BAB29313.1
AK083442 mRNA Translation: BAC38916.1
AK150383 mRNA Translation: BAE29514.1
AK166953 mRNA Translation: BAE39136.1
AK169401 mRNA Translation: BAE41147.1
CH466546 Genomic DNA Translation: EDL41187.1
BC049221 mRNA Translation: AAH49221.1
BC055327 mRNA Translation: AAH55327.1
CCDSiCCDS26544.1
RefSeqiNP_080104.2, NM_025828.3
UniGeneiMm.38868

3D structure databases

ProteinModelPortaliQ9DBH5
SMRiQ9DBH5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211791, 1 interactor
IntActiQ9DBH5, 5 interactors
MINTiQ9DBH5
STRINGi10090.ENSMUSP00000021940

PTM databases

PhosphoSitePlusiQ9DBH5
SwissPalmiQ9DBH5

Proteomic databases

EPDiQ9DBH5
MaxQBiQ9DBH5
PaxDbiQ9DBH5
PeptideAtlasiQ9DBH5
PRIDEiQ9DBH5
TopDownProteomicsiQ9DBH5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021940; ENSMUSP00000021940; ENSMUSG00000021484
GeneIDi66890
KEGGimmu:66890
UCSCiuc007qqo.1 mouse

Organism-specific databases

CTDi10960
MGIiMGI:1914140 Lman2

Phylogenomic databases

eggNOGiKOG3839 Eukaryota
ENOG410YH8V LUCA
GeneTreeiENSGT00530000062977
HOGENOMiHOG000164540
HOVERGENiHBG052334
InParanoidiQ9DBH5
KOiK10082
OMAiDNFEGLG
OrthoDBiEOG091G0AZ1
TreeFamiTF313311

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-5694530 Cargo concentration in the ER

Miscellaneous databases

ChiTaRSiLman2 mouse
PROiPR:Q9DBH5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021484 Expressed in 293 organ(s), highest expression level in embryo
CleanExiMM_LMAN2
GenevisibleiQ9DBH5 MM

Family and domain databases

CDDicd06901 lectin_VIP36_VIPL, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR005052 Lectin_leg
IPR035664 VIP36_lectin
PfamiView protein in Pfam
PF03388 Lectin_leg-like, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51328 L_LECTIN_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLMAN2_MOUSE
AccessioniPrimary (citable) accession number: Q9DBH5
Secondary accession number(s): Q8BJL4, Q9CXG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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