Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Perilipin-3

Gene

Plin3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.By similarity

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-3
Alternative name(s):
Cargo selection protein TIP47
Mannose-6-phosphate receptor-binding protein 1
Gene namesi
Name:Plin3
Synonyms:M6prbp1, Tip47
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914155 Plin3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Lipid droplet, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000998912 – 437Perilipin-3Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei65N6-acetyllysineCombined sources1
Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei130PhosphoserineBy similarity1
Modified residuei174PhosphothreonineBy similarity1
Modified residuei179PhosphoserineBy similarity1
Modified residuei183PhosphoserineBy similarity1
Modified residuei220PhosphothreonineBy similarity1
Modified residuei245PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9DBG5
MaxQBiQ9DBG5
PaxDbiQ9DBG5
PeptideAtlasiQ9DBG5
PRIDEiQ9DBG5

2D gel databases

REPRODUCTION-2DPAGEiIPI00319270

PTM databases

iPTMnetiQ9DBG5
PhosphoSitePlusiQ9DBG5

Expressioni

Gene expression databases

BgeeiENSMUSG00000024197 Expressed in 247 organ(s), highest expression level in epithelium of small intestine
CleanExiMM_M6PRBP1
GenevisibleiQ9DBG5 MM

Interactioni

Subunit structurei

Homooligomer. Interacts with M6PR (via the cytoplasmic domain). Interacts with IGF2R (via the cytoplasmic domain) (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Hspa8P630172EBI-643495,EBI-433443

Protein-protein interaction databases

BioGridi211801, 1 interactor
DIPiDIP-49514N
IntActiQ9DBG5, 3 interactors
MINTiQ9DBG5
STRINGi10090.ENSMUSP00000019726

Structurei

Secondary structure

1437
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9DBG5
SMRiQ9DBG5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DBG5

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili251 – 284Sequence analysisAdd BLAST34
Coiled coili357 – 410Sequence analysisAdd BLAST54

Sequence similaritiesi

Belongs to the perilipin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJG1 Eukaryota
ENOG410XTQ5 LUCA
GeneTreeiENSGT00500000044795
HOGENOMiHOG000033816
HOVERGENiHBG002935
InParanoidiQ9DBG5
KOiK20287
OMAiLGKSEEW
OrthoDBiEOG091G0D6Q
PhylomeDBiQ9DBG5
TreeFamiTF328397

Family and domain databases

InterProiView protein in InterPro
IPR004279 Perilipin
PfamiView protein in Pfam
PF03036 Perilipin, 1 hit
PIRSFiPIRSF036881 PAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DBG5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSNGTDAPA EAQAAMEEPV VQPSVVDRVA GLPLISSTYG MVSAAYTSTK
60 70 80 90 100
ENYPHVRTVC DVAEKGVKTL TTAAVSTAQP ILSKLEPQIA TASEYAHRGL
110 120 130 140 150
DRLQESLPIL QQPTEKVLAD TKELVSSTVS GAQEMVSSSV SSAKETVATR
160 170 180 190 200
VTGAVDVTLG AVQNSVDKTK SAMTSGVQSV MGSRVGQMVI SGVDRVLVKS
210 220 230 240 250
EAWADNRLPL TEAELALIAT PPEDSDMASL QQQRQEQNYF VRLGSLSERL
260 270 280 290 300
RNHAYEHSLG KLQNARQKAQ ETLQQLTSVL GLMESVKQGV DQRLGEGQEK
310 320 330 340 350
LHQMWLSWNQ KTPQDAEKDP AKPEQVEARA LSMFRDITQQ LQSMCVALGA
360 370 380 390 400
SIQGLPSHVR EQAQQARSQV NDLQATFSGI HSFQDLSAGV LAQTRERIAR
410 420 430
AREALDNTVE YVAQNTPAMW LVGPFAPGIT EKTPEGK
Length:437
Mass (Da):47,262
Last modified:June 1, 2001 - v1
Checksum:iF7CDD3A754A5C04D
GO

Sequence cautioni

The sequence BAC33798 differs from that shown. Reason: Frameshift at position 400.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004970 mRNA Translation: BAB23708.1
AK012517 mRNA Translation: BAB28291.1
AK049537 mRNA Translation: BAC33798.1 Frameshift.
AK050140 mRNA Translation: BAC34089.1
AK132313 mRNA Translation: BAE21098.1
AK167214 mRNA Translation: BAE39340.1
BC011116 mRNA Translation: AAH11116.1
CCDSiCCDS28901.1
RefSeqiNP_080112.1, NM_025836.3
UniGeneiMm.311696

Genome annotation databases

EnsembliENSMUST00000019726; ENSMUSP00000019726; ENSMUSG00000024197
GeneIDi66905
KEGGimmu:66905
UCSCiuc008dbn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004970 mRNA Translation: BAB23708.1
AK012517 mRNA Translation: BAB28291.1
AK049537 mRNA Translation: BAC33798.1 Frameshift.
AK050140 mRNA Translation: BAC34089.1
AK132313 mRNA Translation: BAE21098.1
AK167214 mRNA Translation: BAE39340.1
BC011116 mRNA Translation: AAH11116.1
CCDSiCCDS28901.1
RefSeqiNP_080112.1, NM_025836.3
UniGeneiMm.311696

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SZIX-ray2.80A191-437[»]
ProteinModelPortaliQ9DBG5
SMRiQ9DBG5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211801, 1 interactor
DIPiDIP-49514N
IntActiQ9DBG5, 3 interactors
MINTiQ9DBG5
STRINGi10090.ENSMUSP00000019726

PTM databases

iPTMnetiQ9DBG5
PhosphoSitePlusiQ9DBG5

2D gel databases

REPRODUCTION-2DPAGEiIPI00319270

Proteomic databases

EPDiQ9DBG5
MaxQBiQ9DBG5
PaxDbiQ9DBG5
PeptideAtlasiQ9DBG5
PRIDEiQ9DBG5

Protocols and materials databases

DNASUi66905
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019726; ENSMUSP00000019726; ENSMUSG00000024197
GeneIDi66905
KEGGimmu:66905
UCSCiuc008dbn.1 mouse

Organism-specific databases

CTDi10226
MGIiMGI:1914155 Plin3

Phylogenomic databases

eggNOGiENOG410IJG1 Eukaryota
ENOG410XTQ5 LUCA
GeneTreeiENSGT00500000044795
HOGENOMiHOG000033816
HOVERGENiHBG002935
InParanoidiQ9DBG5
KOiK20287
OMAiLGKSEEW
OrthoDBiEOG091G0D6Q
PhylomeDBiQ9DBG5
TreeFamiTF328397

Enzyme and pathway databases

ReactomeiR-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

EvolutionaryTraceiQ9DBG5
PROiPR:Q9DBG5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024197 Expressed in 247 organ(s), highest expression level in epithelium of small intestine
CleanExiMM_M6PRBP1
GenevisibleiQ9DBG5 MM

Family and domain databases

InterProiView protein in InterPro
IPR004279 Perilipin
PfamiView protein in Pfam
PF03036 Perilipin, 1 hit
PIRSFiPIRSF036881 PAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLIN3_MOUSE
AccessioniPrimary (citable) accession number: Q9DBG5
Secondary accession number(s): Q3TK05, Q8BKV9, Q9CZK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again