UniProtKB - Q9DBD5 (PELP1_MOUSE)
Proline-, glutamic acid- and leucine-rich protein 1
Pelp1
Functioni
GO - Molecular functioni
- chromatin binding Source: UniProtKB
- transcription factor binding Source: MGI
GO - Biological processi
- cellular response to estrogen stimulus Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
Keywordsi
Molecular function | Activator, Repressor |
Biological process | Transcription |
Enzyme and pathway databases
Reactomei | R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: Proline-, glutamic acid- and leucine-rich protein 1Alternative name(s): Modulator of non-genomic activity of estrogen receptor |
Gene namesi | Name:Pelp1 Synonyms:Mnar |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1922523, Pelp1 |
Subcellular locationi
Nucleus
- nucleolus By similarity
- nucleoplasm 1 Publication
- Nucleus 1 Publication
Other locations
- Cytoplasm 1 Publication
Note: Mainly found in the nucleoplasm, with low levels detected in the cytoplasm. Also found associated with the plasma membrane.1 Publication
Nucleus
- MLL1 complex Source: UniProtKB
- nucleolus Source: MGI
- nucleoplasm Source: MGI
Other locations
- cytoplasm Source: UniProtKB-SubCell
- transcriptionally active chromatin Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000252137 | 2 – 1123 | Proline-, glutamic acid- and leucine-rich protein 1Add BLAST | 1122 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 13 | PhosphoserineCombined sources | 1 | |
Modified residuei | 478 | PhosphoserineBy similarity | 1 | |
Modified residuei | 482 | PhosphoserineBy similarity | 1 | |
Modified residuei | 751 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 755 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1029 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1039 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9DBD5 |
jPOSTi | Q9DBD5 |
MaxQBi | Q9DBD5 |
PaxDbi | Q9DBD5 |
PeptideAtlasi | Q9DBD5 |
PRIDEi | Q9DBD5 |
PTM databases
iPTMneti | Q9DBD5 |
PhosphoSitePlusi | Q9DBD5 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000018921, Expressed in cardiac ventricle and 289 other tissues |
ExpressionAtlasi | Q9DBD5, baseline and differential |
Genevisiblei | Q9DBD5, MM |
Interactioni
Subunit structurei
Interacts with HRS, RXRA, SUMO2, HDAC2, RB1 and STAT3.
Interacts with PI3K, SRC and EGFR in cytoplasm.
Interacts with ESR1 and ESR2 and this interaction is enhanced by 17-beta-estradiol.
Interacts with CREBBP, EP300, AR and NR3C1 in a ligand-dependent manner. Forms two complexes in the presence of 17-beta-estradiol; one with SRC and ESR1 and another with LCK and ESR1.
Interacts with histone H1 and H3 with a greater affinity for H1.
Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity). Core component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148.
Interacts with NOL9 (PubMed:22872859).
Interacts with BCAS3 (By similarity).
Component of the PELP1 complex, composed of at least PELP1, TEX10 and WDR18. The complex interacts (via PELP1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles (By similarity).
By similarity1 PublicationBinary interactionsi
Q9DBD5
With | #Exp. | IntAct |
---|---|---|
Nr4a1 [P12813] | 3 | EBI-6909114,EBI-10896863 |
GO - Molecular functioni
- transcription factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 217350, 6 interactors |
IntActi | Q9DBD5, 4 interactors |
MINTi | Q9DBD5 |
STRINGi | 10090.ENSMUSP00000019065 |
Miscellaneous databases
RNActi | Q9DBD5, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 33 – 37 | LXXLL motif 1 | 5 | |
Motifi | 69 – 73 | LXXLL motif 2 | 5 | |
Motifi | 111 – 115 | LXXLL motif 3 | 5 | |
Motifi | 155 – 159 | LXXLL motif 4 | 5 | |
Motifi | 177 – 181 | LXXLL motif 5 | 5 | |
Motifi | 264 – 268 | LXXLL motif 6 | 5 | |
Motifi | 271 – 275 | LXXLL motif 7 | 5 | |
Motifi | 365 – 369 | LXXLL motif 8 | 5 | |
Motifi | 460 – 464 | LXXLL motif 9 | 5 | |
Motifi | 580 – 584 | LXXLL motif 10 | 5 | |
Motifi | 585 – 589 | LXXLL motif 11 | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 33 – 407 | Leu-richAdd BLAST | 375 | |
Compositional biasi | 634 – 876 | Pro-richAdd BLAST | 243 | |
Compositional biasi | 893 – 1094 | Glu-richAdd BLAST | 202 | |
Compositional biasi | 974 – 1121 | Pro-richAdd BLAST | 148 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QQE7, Eukaryota |
GeneTreei | ENSGT00730000111225 |
HOGENOMi | CLU_007599_0_0_1 |
InParanoidi | Q9DBD5 |
OMAi | FRAPAFH |
OrthoDBi | 427039at2759 |
TreeFami | TF331332 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR012583, RIX1_N IPR012980, Uncharacterised_NUC202 |
Pfami | View protein in Pfam PF08166, NUC202, 2 hits PF08167, RIX1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAAAVLSGAS AGSPAGAPGG PGGLSAVGSG PRLRLLLLES ISGLLQPRTA
60 70 80 90 100
SPVAPVHPPI QWAPHLPGLM CLLRLHGTAG GAQNLSALGA LVNLSNAHLG
110 120 130 140 150
SIKTRFEGLC LLSLLIGESP TELFQQHCVS WLRSIQQVLQ SQDSPSTMEL
160 170 180 190 200
AVAVLRDLLR HASQLPTLFR DISTNHLPGL LTSLLGLRPE CEQSALEGMK
210 220 230 240 250
ACVTYFPRAC GSLKGKLASF FLSRLDSLNP QLQQLACECY SRLPSLGAGF
260 270 280 290 300
SQGLKHTENW EQELHSLLTS LHSLLGSLFE ETEPAPVQSE GPGIEMLLSH
310 320 330 340 350
SEDGNTHVLL QLRQRFSGLA RCLGLMLSSE FGAPVSVPVQ EILDLICRIL
360 370 380 390 400
GISSKNINLL GDGPLRLLLL PSLHLEALDL LSALILACGS RLLRFGALIS
410 420 430 440 450
RLLPQVLNAW STGRDTLAPG QERPYSTIRT KVYAILELWV QVCGASAGML
460 470 480 490 500
QGGASGEALL THLLSDISPP ADALKLCSTR GSSDGGLQSG KPSAPKKLKL
510 520 530 540 550
DMGEALAPPS QRKGDRNANS DVCAAALRGL SRTILMCGPL IKEETHRRLH
560 570 580 590 600
DLVLPLVMSV QQGEVLGSSP YNSSCCRLGL YRLLLALLLA PSPRCPPPLA
610 620 630 640 650
CALKAFSLGQ WEDSLEVSSF CSEALVTCAA LTHPRVPPLQ SSGPACPTPA
660 670 680 690 700
PVPPPEAPSS FRAPAFHPPG PMPSIGAVPS TGPLPSAGPI PTVGSMASTG
710 720 730 740 750
QVPSRPGPPA TANHLGLSVP GLVSVPPRLL PGPENHRAGS GEDPVLAPSG
760 770 780 790 800
TPPPSIPPDE TFGGRVPRPA FVHYDKEEAS DVEISLESDS DDSVVIVPEG
810 820 830 840 850
LPSLPPAPPS GTPPPAAPAG PPTASPPVPA KEDSEELPAT PGPPPPPPPP
860 870 880 890 900
PPPASGPVTL PPPQLVPEGT PGGGGPTAME EDLTVININS SDEEEEEEEE
910 920 930 940 950
EEEEDEDEEE EDFEEEEEDE EEYFEEEEEE EEFEEEFEEE EGELEEEEEE
960 970 980 990 1000
EEEELDEVED VEFGSAGEVE EGGPPPPTLP PALPPSDSPK VQPEAEPEPG
1010 1020 1030 1040 1050
LLLEVEEPGP EEVPGPETAP TLAPEVLPSQ EEGEQEVGSP AAGPPQELVE
1060 1070 1080 1090 1100
ESSAPPALLE EGTEGGGDKV PPPPETPAEE METEAEVPAP QEKEQDDTAA
1110 1120
MLADFIDCPP DDEKPPPATE PDS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ9D4T3 | Q9D4T3_MOUSE | Proline-, glutamic acid- and leucin... | Pelp1 | 164 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 566 | L → P in AAH16444 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 566 | L → P in AAH57987 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 864 | Q → L in BAB23754 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK005027 mRNA Translation: BAB23754.1 AL596096 Genomic DNA No translation available. BC016444 mRNA Translation: AAH16444.1 BC057987 mRNA Translation: AAH57987.1 BC090620 mRNA Translation: AAH90620.1 |
CCDSi | CCDS24945.1 |
RefSeqi | NP_083507.3, NM_029231.4 |
Genome annotation databases
Ensembli | ENSMUST00000019065; ENSMUSP00000019065; ENSMUSG00000018921 |
GeneIDi | 75273 |
KEGGi | mmu:75273 |
UCSCi | uc007jup.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK005027 mRNA Translation: BAB23754.1 AL596096 Genomic DNA No translation available. BC016444 mRNA Translation: AAH16444.1 BC057987 mRNA Translation: AAH57987.1 BC090620 mRNA Translation: AAH90620.1 |
CCDSi | CCDS24945.1 |
RefSeqi | NP_083507.3, NM_029231.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 217350, 6 interactors |
IntActi | Q9DBD5, 4 interactors |
MINTi | Q9DBD5 |
STRINGi | 10090.ENSMUSP00000019065 |
PTM databases
iPTMneti | Q9DBD5 |
PhosphoSitePlusi | Q9DBD5 |
Proteomic databases
EPDi | Q9DBD5 |
jPOSTi | Q9DBD5 |
MaxQBi | Q9DBD5 |
PaxDbi | Q9DBD5 |
PeptideAtlasi | Q9DBD5 |
PRIDEi | Q9DBD5 |
Protocols and materials databases
Antibodypediai | 23315, 258 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000019065; ENSMUSP00000019065; ENSMUSG00000018921 |
GeneIDi | 75273 |
KEGGi | mmu:75273 |
UCSCi | uc007jup.2, mouse |
Organism-specific databases
CTDi | 27043 |
MGIi | MGI:1922523, Pelp1 |
Phylogenomic databases
eggNOGi | ENOG502QQE7, Eukaryota |
GeneTreei | ENSGT00730000111225 |
HOGENOMi | CLU_007599_0_0_1 |
InParanoidi | Q9DBD5 |
OMAi | FRAPAFH |
OrthoDBi | 427039at2759 |
TreeFami | TF331332 |
Enzyme and pathway databases
Reactomei | R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 75273, 10 hits in 19 CRISPR screens |
ChiTaRSi | Pelp1, mouse |
PROi | PR:Q9DBD5 |
RNActi | Q9DBD5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000018921, Expressed in cardiac ventricle and 289 other tissues |
ExpressionAtlasi | Q9DBD5, baseline and differential |
Genevisiblei | Q9DBD5, MM |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR012583, RIX1_N IPR012980, Uncharacterised_NUC202 |
Pfami | View protein in Pfam PF08166, NUC202, 2 hits PF08167, RIX1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PELP1_MOUSE | |
Accessioni | Q9DBD5Primary (citable) accession number: Q9DBD5 Secondary accession number(s): Q5F2E2, Q6PEM0, Q91YM9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | October 17, 2006 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families