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Entry version 139 (12 Aug 2020)
Sequence version 1 (01 Jun 2001)
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Protein

Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

Gene

Cmtr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m7GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m7GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei217SubstrateBy similarity1
Binding sitei233S-adenosyl-L-methionineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei238By similarity1
Active sitei363By similarity1
Active sitei403Proton acceptorPROSITE-ProRule annotation1
Binding sitei438SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processmRNA capping, mRNA processing
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC:2.1.1.57)
Alternative name(s):
Cap methyltransferase 1
Cap1 2'O-ribose methyltransferase 1
Short name:
MTr1
FtsJ methyltransferase domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cmtr1
Synonyms:Ftsjd2, Kiaa0082
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1921407, Cmtr1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002512401 – 837Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1Add BLAST837

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei27PhosphoserineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei52PhosphoserineBy similarity1
Modified residuei90PhosphoserineBy similarity1
Modified residuei107N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9DBC3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9DBC3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9DBC3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9DBC3

PeptideAtlas

More...
PeptideAtlasi
Q9DBC3

PRoteomics IDEntifications database

More...
PRIDEi
Q9DBC3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9DBC3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9DBC3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024019, Expressed in granulocyte and 66 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9DBC3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9DBC3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with POLR2A (via C-terminus).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
216534, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000024816

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9DBC3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9DBC3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini86 – 132G-patchPROSITE-ProRule annotationAdd BLAST47
Domaini230 – 449RrmJ-type SAM-dependent 2'-O-MTasePROSITE-ProRule annotationAdd BLAST220
Domaini751 – 785WWPROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni202 – 206Substrate bindingBy similarity5
Regioni276 – 282S-adenosyl-L-methionine bindingBy similarity7
Regioni334 – 335S-adenosyl-L-methionine bindingBy similarity2
Regioni373 – 375Substrate bindingBy similarity3
Regioni726 – 834Interaction with POLR2ABy similarityAdd BLAST109

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2 – 18Bipartite nuclear localization signalPROSITE-ProRule annotationAdd BLAST17

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3673, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157172

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011097_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9DBC3

KEGG Orthology (KO)

More...
KOi
K14589

Identification of Orthologs from Complete Genome Data

More...
OMAi
DSQKRQD

Database of Orthologous Groups

More...
OrthoDBi
1336442at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9DBC3

TreeFam database of animal gene trees

More...
TreeFami
TF314897

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00201, WW, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030376, Cap_mRNA_MeTrfase_1
IPR000467, G_patch_dom
IPR025816, RrmJ-type_MeTrfase
IPR002877, rRNA_MeTrfase_FtsJ_dom
IPR029063, SAM-dependent_MTases
IPR001202, WW_dom

The PANTHER Classification System

More...
PANTHERi
PTHR16121:SF0, PTHR16121:SF0, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01728, FtsJ, 1 hit
PF01585, G-patch, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00443, G_patch, 1 hit
SM00456, WW, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50174, G_PATCH, 1 hit
PS51613, SAM_MT_RRMJ, 1 hit
PS50020, WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q9DBC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRRTDPECT APLKKQKRIG ELARHLSSTS DDEPLSSVNH AAKASATSLS
60 70 80 90 100
GSDSETEGKQ PCSDDFKDAF KADSLVEGTS SRYSMYNSVS QRLMAKMGFR
110 120 130 140 150
EGEGLGKYSQ GRKDIVETSN QKGRRGLGLT LQGFDQELNV DWRDEPEPNA
160 170 180 190 200
CEQVSWFPEC TTEIPDSREM SDWMVVGKRK MVIEDETEFC GEELLHSMLK
210 220 230 240 250
CKSVFDILDG EEMRRARTRA NPYEMIRGVF FLNRAAMKMA NMDFVFDRMF
260 270 280 290 300
TNPLDSSGKP LLKESDIDLL YFADVCAGPG GFSEYVLWRK KWHAKGFGMT
310 320 330 340 350
LKGPNDFKLE DFYSASSELF EPYYGEGGVD GDGDITRPEN INAFRNFVLD
360 370 380 390 400
NTDRKGVHFV MADGGFSVEG QENLQEILSK QLLLCQFLMA LSVVRTGGHF
410 420 430 440 450
VCKTFDLFTP FSVGLIYLLY CCFERVCLFK PITSRPANSE RYVVCKGLKV
460 470 480 490 500
GIDDVREYLF SVNIKLNQLR NTESDVNLVV PLMVIKGDHE FNDYMIRSNE
510 520 530 540 550
SYCSLQIKAL AKIHAFVQDT TLSEPRQAEI RKECLQLWKI PDQARVAPSS
560 570 580 590 600
SDPKFKFFEL IKDTDINIFS YKPTLLTAKT LEKIRPVLEY RCMVSGSEQK
610 620 630 640 650
FLLGLGKSQI YTWDGRQSDR WVKLDLKTEL PRDTLLCVEI VHELKGEGKA
660 670 680 690 700
QRKISAIHIL DVLVLNGSDV REQHFNQRIQ LAEKFVKAVS KPSRPDMNPI
710 720 730 740 750
RVKEVYRLEE MEKIFVRLEM KLIKGSGGTP KLSYTGRDDR HFVPTGVYIV
760 770 780 790 800
RTVNEPWTMG FSKSNNRKFF YNKKTQKSVY ALPTESIAPF HTCYYSRLFW
810 820 830
EWGDGFHMRD SQKPQDPDKL SKEDVLSFIQ SHNPLGP
Length:837
Mass (Da):95,676
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8DB980D2FFA4F9C7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q4EHZ1A0A3Q4EHZ1_MOUSE
Cap methyltransferase 1
Cmtr1
844Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q4EBV9A0A3Q4EBV9_MOUSE
Cap-specific mRNA (nucleoside-2'-O-...
Cmtr1
369Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q4EH87A0A3Q4EH87_MOUSE
Cap-specific mRNA (nucleoside-2'-O-...
Cmtr1
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z491D3Z491_MOUSE
Cap-specific mRNA (nucleoside-2'-O-...
Cmtr1 Ftsjd2
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZ59G3UZ59_MOUSE
Cap-specific mRNA (nucleoside-2'-O-...
Cmtr1 Ftsjd2
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q4EIG4A0A3Q4EIG4_MOUSE
Cap-specific mRNA (nucleoside-2'-O-...
Cmtr1
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q4EGE1A0A3Q4EGE1_MOUSE
Cap-specific mRNA (nucleoside-2'-O-...
Cmtr1
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q4EIE2A0A3Q4EIE2_MOUSE
Cap-specific mRNA (nucleoside-2'-O-...
Cmtr1
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q4L303A0A3Q4L303_MOUSE
Cap-specific mRNA (nucleoside-2'-O-...
Cmtr1
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32161 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti151C → W in BAE32821 (PubMed:16141072).Curated1
Sequence conflicti378L → F in BAE31091 (PubMed:16141072).Curated1
Sequence conflicti378L → F in BAE31230 (PubMed:16141072).Curated1
Sequence conflicti459L → I in BAE31091 (PubMed:16141072).Curated1
Sequence conflicti459L → I in BAE31230 (PubMed:16141072).Curated1
Sequence conflicti500E → V in BAE31091 (PubMed:16141072).Curated1
Sequence conflicti500E → V in BAE31230 (PubMed:16141072).Curated1
Sequence conflicti689V → I in BAC33600 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK005044 mRNA Translation: BAB23771.1
AK042060 mRNA Translation: BAC31146.1
AK043733 mRNA Translation: BAC31634.1
AK049190 mRNA Translation: BAC33600.1
AK080379 mRNA Translation: BAC37899.1
AK150392 mRNA Translation: BAE29520.1
AK151194 mRNA Translation: BAE30191.1
AK152276 mRNA Translation: BAE31091.1
AK152452 mRNA Translation: BAE31230.1
AK152799 mRNA Translation: BAE31504.1
AK153021 mRNA Translation: BAE31655.1
AK153066 mRNA Translation: BAE31692.1
AK154773 mRNA Translation: BAE32821.1
BC024691 mRNA Translation: AAH24691.1
AK172883 Transcribed RNA Translation: BAD32161.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37539.1

NCBI Reference Sequences

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RefSeqi
NP_083067.1, NM_028791.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000024816; ENSMUSP00000024816; ENSMUSG00000024019

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
74157

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:74157

UCSC genome browser

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UCSCi
uc008bth.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005044 mRNA Translation: BAB23771.1
AK042060 mRNA Translation: BAC31146.1
AK043733 mRNA Translation: BAC31634.1
AK049190 mRNA Translation: BAC33600.1
AK080379 mRNA Translation: BAC37899.1
AK150392 mRNA Translation: BAE29520.1
AK151194 mRNA Translation: BAE30191.1
AK152276 mRNA Translation: BAE31091.1
AK152452 mRNA Translation: BAE31230.1
AK152799 mRNA Translation: BAE31504.1
AK153021 mRNA Translation: BAE31655.1
AK153066 mRNA Translation: BAE31692.1
AK154773 mRNA Translation: BAE32821.1
BC024691 mRNA Translation: AAH24691.1
AK172883 Transcribed RNA Translation: BAD32161.1 Frameshift.
CCDSiCCDS37539.1
RefSeqiNP_083067.1, NM_028791.6

3D structure databases

SMRiQ9DBC3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi216534, 3 interactors
STRINGi10090.ENSMUSP00000024816

PTM databases

iPTMnetiQ9DBC3
PhosphoSitePlusiQ9DBC3

Proteomic databases

EPDiQ9DBC3
jPOSTiQ9DBC3
MaxQBiQ9DBC3
PaxDbiQ9DBC3
PeptideAtlasiQ9DBC3
PRIDEiQ9DBC3

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
29815, 49 antibodies

Genome annotation databases

EnsembliENSMUST00000024816; ENSMUSP00000024816; ENSMUSG00000024019
GeneIDi74157
KEGGimmu:74157
UCSCiuc008bth.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23070
MGIiMGI:1921407, Cmtr1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG3673, Eukaryota
GeneTreeiENSGT00940000157172
HOGENOMiCLU_011097_0_0_1
InParanoidiQ9DBC3
KOiK14589
OMAiDSQKRQD
OrthoDBi1336442at2759
PhylomeDBiQ9DBC3
TreeFamiTF314897

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
74157, 8 hits in 20 CRISPR screens

Protein Ontology

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PROi
PR:Q9DBC3
RNActiQ9DBC3, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000024019, Expressed in granulocyte and 66 other tissues
ExpressionAtlasiQ9DBC3, baseline and differential
GenevisibleiQ9DBC3, MM

Family and domain databases

CDDicd00201, WW, 1 hit
InterProiView protein in InterPro
IPR030376, Cap_mRNA_MeTrfase_1
IPR000467, G_patch_dom
IPR025816, RrmJ-type_MeTrfase
IPR002877, rRNA_MeTrfase_FtsJ_dom
IPR029063, SAM-dependent_MTases
IPR001202, WW_dom
PANTHERiPTHR16121:SF0, PTHR16121:SF0, 1 hit
PfamiView protein in Pfam
PF01728, FtsJ, 1 hit
PF01585, G-patch, 1 hit
SMARTiView protein in SMART
SM00443, G_patch, 1 hit
SM00456, WW, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS50174, G_PATCH, 1 hit
PS51613, SAM_MT_RRMJ, 1 hit
PS50020, WW_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCMTR1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9DBC3
Secondary accession number(s): Q3U3G5
, Q3U7Y9, Q6A0D5, Q8C7V0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: August 12, 2020
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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